Self-assembly of Janus dendrimers into uniform dendrimersomes and other complex architectures
Self-assembled nanostructures obtained from natural and synthetic amphiphiles serve as mimics of biological membranes and enable the delivery of drugs, proteins, genes, and imaging agents. Yet the precise molecular arrangements demanded by these functions are difficult to achieve. Libraries of amphiphilic Janus dendrimers, prepared by facile coupling of tailored hydrophilic and hydrophobic branched segments, have been screened by cryogenic transmission electron microscopy, revealing a rich palette of morphologies in water, including vesicles, denoted dendrimersomes, cubosomes, disks, tubular vesicles, and helical ribbons. Dendrimersomes marry the stability and mechanical strength obtainable from polymersomes with the biological function of stabilized phospholipid liposomes, plus superior uniformity of size, ease of formation, and chemical functionalization. This modular synthesis strategy provides access to systematic tuning of molecular structure and of self-assembled architecture.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2010 |
|---|---|
| Erschienen: |
2010 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:328 |
|---|---|
| Enthalten in: |
Science (New York, N.Y.) - 328(2010), 5981 vom: 21. Mai, Seite 1009-14 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Percec, Virgil [VerfasserIn] |
|---|
| Links: |
|---|
| Anmerkungen: |
Date Completed 02.06.2010 Date Revised 21.11.2013 published: Print Citation Status MEDLINE |
|---|
| doi: |
10.1126/science.1185547 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM198268092 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM198268092 | ||
| 003 | DE-627 | ||
| 005 | 20231223212344.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231223s2010 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1126/science.1185547 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n0661.xml |
| 035 | |a (DE-627)NLM198268092 | ||
| 035 | |a (NLM)20489021 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Percec, Virgil |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Self-assembly of Janus dendrimers into uniform dendrimersomes and other complex architectures |
| 264 | 1 | |c 2010 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 02.06.2010 | ||
| 500 | |a Date Revised 21.11.2013 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Self-assembled nanostructures obtained from natural and synthetic amphiphiles serve as mimics of biological membranes and enable the delivery of drugs, proteins, genes, and imaging agents. Yet the precise molecular arrangements demanded by these functions are difficult to achieve. Libraries of amphiphilic Janus dendrimers, prepared by facile coupling of tailored hydrophilic and hydrophobic branched segments, have been screened by cryogenic transmission electron microscopy, revealing a rich palette of morphologies in water, including vesicles, denoted dendrimersomes, cubosomes, disks, tubular vesicles, and helical ribbons. Dendrimersomes marry the stability and mechanical strength obtainable from polymersomes with the biological function of stabilized phospholipid liposomes, plus superior uniformity of size, ease of formation, and chemical functionalization. This modular synthesis strategy provides access to systematic tuning of molecular structure and of self-assembled architecture | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Research Support, U.S. Gov't, Non-P.H.S. | |
| 650 | 7 | |a Antibiotics, Antineoplastic |2 NLM | |
| 650 | 7 | |a Dendrimers |2 NLM | |
| 650 | 7 | |a Drug Carriers |2 NLM | |
| 650 | 7 | |a Membranes, Artificial |2 NLM | |
| 650 | 7 | |a Surface-Active Agents |2 NLM | |
| 650 | 7 | |a Water |2 NLM | |
| 650 | 7 | |a 059QF0KO0R |2 NLM | |
| 650 | 7 | |a Doxorubicin |2 NLM | |
| 650 | 7 | |a 80168379AG |2 NLM | |
| 700 | 1 | |a Wilson, Daniela A |e verfasserin |4 aut | |
| 700 | 1 | |a Leowanawat, Pawaret |e verfasserin |4 aut | |
| 700 | 1 | |a Wilson, Christopher J |e verfasserin |4 aut | |
| 700 | 1 | |a Hughes, Andrew D |e verfasserin |4 aut | |
| 700 | 1 | |a Kaucher, Mark S |e verfasserin |4 aut | |
| 700 | 1 | |a Hammer, Daniel A |e verfasserin |4 aut | |
| 700 | 1 | |a Levine, Dalia H |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Anthony J |e verfasserin |4 aut | |
| 700 | 1 | |a Bates, Frank S |e verfasserin |4 aut | |
| 700 | 1 | |a Davis, Kevin P |e verfasserin |4 aut | |
| 700 | 1 | |a Lodge, Timothy P |e verfasserin |4 aut | |
| 700 | 1 | |a Klein, Michael L |e verfasserin |4 aut | |
| 700 | 1 | |a DeVane, Russell H |e verfasserin |4 aut | |
| 700 | 1 | |a Aqad, Emad |e verfasserin |4 aut | |
| 700 | 1 | |a Rosen, Brad M |e verfasserin |4 aut | |
| 700 | 1 | |a Argintaru, Andreea O |e verfasserin |4 aut | |
| 700 | 1 | |a Sienkowska, Monika J |e verfasserin |4 aut | |
| 700 | 1 | |a Rissanen, Kari |e verfasserin |4 aut | |
| 700 | 1 | |a Nummelin, Sami |e verfasserin |4 aut | |
| 700 | 1 | |a Ropponen, Jarmo |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Science (New York, N.Y.) |d 1880 |g 328(2010), 5981 vom: 21. Mai, Seite 1009-14 |w (DE-627)NLM000023450 |x 1095-9203 |7 nnns |
| 773 | 1 | 8 | |g volume:328 |g year:2010 |g number:5981 |g day:21 |g month:05 |g pages:1009-14 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1126/science.1185547 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 328 |j 2010 |e 5981 |b 21 |c 05 |h 1009-14 | ||