Statin administration and risk of cholecystectomy : a population-based case-control study
BACKGROUND: Gallstone disease is common in Western countries. Statins reduce biliary cholesterol secretion and have anti-inflammatory effects, suggesting that they may play a role in reducing the incidence of surgically treated gallstone disease.
AIM: To examine a potential association between statin administration and risk of cholecystectomy.
METHODS: We conducted a population-based case-control study of surgically treated gallstone disease using the database of Clalit Health Services (CHS). The study population consisted of all individuals age 40 - 85 enrolled with the central region of CHS during the period 1 January 2000 to 31 December 2006. We identified patients who underwent cholecystectomy between 1 January 2003 and 31 December 2006 (n = 1465). Controls (n = 5860) were individually matched on year of birth and sex in a 4:1 ratio. Multivariable conditional logistic regression models to compute the odds ratio of cholecystectomy associated with statin therapy were constructed to control for patients' clinical and socio-demographic characteristics.
RESULTS: Statin use with at least 80% adherence to treatment was associated with about 30% reduction in the risk of cholecystectomy (adjusted odds ratio 0.69; 95% CI 0.57 - 0.84).
CONCLUSION: The results of our large population-based study suggest that the use of statins reduces the risk of surgery for gallstone disease.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2010 |
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| Erschienen: |
2010 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:9 |
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| Enthalten in: |
Expert opinion on drug safety - 9(2010), 4 vom: 15. Juli, Seite 539-43 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Merzon, Eugene [VerfasserIn] |
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| Links: |
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| Themen: |
Anticholesteremic Agents |
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| Anmerkungen: |
Date Completed 29.09.2010 Date Revised 17.06.2010 published: Print Citation Status MEDLINE |
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| doi: |
10.1517/14740338.2010.485190 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM198204515 |
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| 245 | 1 | 0 | |a Statin administration and risk of cholecystectomy |b a population-based case-control study |
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| 500 | |a Date Completed 29.09.2010 | ||
| 500 | |a Date Revised 17.06.2010 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: Gallstone disease is common in Western countries. Statins reduce biliary cholesterol secretion and have anti-inflammatory effects, suggesting that they may play a role in reducing the incidence of surgically treated gallstone disease | ||
| 520 | |a AIM: To examine a potential association between statin administration and risk of cholecystectomy | ||
| 520 | |a METHODS: We conducted a population-based case-control study of surgically treated gallstone disease using the database of Clalit Health Services (CHS). The study population consisted of all individuals age 40 - 85 enrolled with the central region of CHS during the period 1 January 2000 to 31 December 2006. We identified patients who underwent cholecystectomy between 1 January 2003 and 31 December 2006 (n = 1465). Controls (n = 5860) were individually matched on year of birth and sex in a 4:1 ratio. Multivariable conditional logistic regression models to compute the odds ratio of cholecystectomy associated with statin therapy were constructed to control for patients' clinical and socio-demographic characteristics | ||
| 520 | |a RESULTS: Statin use with at least 80% adherence to treatment was associated with about 30% reduction in the risk of cholecystectomy (adjusted odds ratio 0.69; 95% CI 0.57 - 0.84) | ||
| 520 | |a CONCLUSION: The results of our large population-based study suggest that the use of statins reduces the risk of surgery for gallstone disease | ||
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Anticholesteremic Agents |2 NLM | |
| 650 | 7 | |a Hydroxymethylglutaryl-CoA Reductase Inhibitors |2 NLM | |
| 700 | 1 | |a Weiss, Noel S |e verfasserin |4 aut | |
| 700 | 1 | |a Lustman, Alex James |e verfasserin |4 aut | |
| 700 | 1 | |a Elhayani, Asher |e verfasserin |4 aut | |
| 700 | 1 | |a Dresner, Julian |e verfasserin |4 aut | |
| 700 | 1 | |a Vinker, Shlomo |e verfasserin |4 aut | |
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