Antiphospholipid syndrome with autoimmune hemolytic anemia which mimics thrombotic thrombocytopenic purpura
A 67-year-old woman was admitted to the hospital for lethargy, fever, hemolytic anemia, thrombocytopenia, and consciousness disturbance. Direct Coombs test was positive, and anti-cardiolipin beta2-glycoprotein I antibody was detected. She was diagnosed with antiphospholipid syndrome complicated with autoimmune hemolytic anemia (AIHA). She demonstrated variable consciousness disturbance, inability to distinguish right from left, dysgraphia and dyscalculia. Multiple cerebral infarctions, especially dominant cerebral hemisphere infarctions, were observed on magnetic resonance imaging. A ventilation-perfusion scan demonstrated the presence of a ventilation-perfusion mismatch in both lung fields, and multiple veinous embolisms in the right femoral, bilateral the great saphenous and popliteal veins. Therefore, pulmonary embolism and thrombophlebitis were diagnosed. Based on these findings, it was necessary to distinguish this diagnosis from thrombotic thrombocytopenic purpura (TTP). As ADAMTS-13 activity was within the normal range, TTP was denied. Thereafter, the patient was treated with 1 mg/kg of prednisolone for AIHA, 3 mg of warfarin, and 3500 units of low-molecular-weight heparin for thrombosis, and her condition improved.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2010 |
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| Erschienen: |
2010 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:51 |
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| Enthalten in: |
Rinsho ketsueki] The Japanese journal of clinical hematology - 51(2010), 4 vom: 31. Apr., Seite 275-80 |
| Sprache: |
Japanisch |
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| Beteiligte Personen: |
Karasawa, Naoki [VerfasserIn] |
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| Anmerkungen: |
Date Completed 01.07.2010 Date Revised 25.11.2016 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM198060432 |
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| 100 | 1 | |a Karasawa, Naoki |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Antiphospholipid syndrome with autoimmune hemolytic anemia which mimics thrombotic thrombocytopenic purpura |
| 264 | 1 | |c 2010 | |
| 336 | |a Text |b txt |2 rdacontent | ||
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| 500 | |a Date Completed 01.07.2010 | ||
| 500 | |a Date Revised 25.11.2016 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a A 67-year-old woman was admitted to the hospital for lethargy, fever, hemolytic anemia, thrombocytopenia, and consciousness disturbance. Direct Coombs test was positive, and anti-cardiolipin beta2-glycoprotein I antibody was detected. She was diagnosed with antiphospholipid syndrome complicated with autoimmune hemolytic anemia (AIHA). She demonstrated variable consciousness disturbance, inability to distinguish right from left, dysgraphia and dyscalculia. Multiple cerebral infarctions, especially dominant cerebral hemisphere infarctions, were observed on magnetic resonance imaging. A ventilation-perfusion scan demonstrated the presence of a ventilation-perfusion mismatch in both lung fields, and multiple veinous embolisms in the right femoral, bilateral the great saphenous and popliteal veins. Therefore, pulmonary embolism and thrombophlebitis were diagnosed. Based on these findings, it was necessary to distinguish this diagnosis from thrombotic thrombocytopenic purpura (TTP). As ADAMTS-13 activity was within the normal range, TTP was denied. Thereafter, the patient was treated with 1 mg/kg of prednisolone for AIHA, 3 mg of warfarin, and 3500 units of low-molecular-weight heparin for thrombosis, and her condition improved | ||
| 650 | 4 | |a Case Reports | |
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Anticoagulants |2 NLM | |
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| 650 | 7 | |a Warfarin |2 NLM | |
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| 650 | 7 | |a Prednisolone |2 NLM | |
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| 650 | 7 | |a ADAM Proteins |2 NLM | |
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| 700 | 1 | |a Taniguchi, Yasuhiro |e verfasserin |4 aut | |
| 700 | 1 | |a Hidaka, Tomonori |e verfasserin |4 aut | |
| 700 | 1 | |a Katayose, Keiko |e verfasserin |4 aut | |
| 700 | 1 | |a Kameda, Takuro |e verfasserin |4 aut | |
| 700 | 1 | |a Side, Kotaro |e verfasserin |4 aut | |
| 700 | 1 | |a Shimoda, Haruko |e verfasserin |4 aut | |
| 700 | 1 | |a Nagata, Kenji |e verfasserin |4 aut | |
| 700 | 1 | |a Kubuki, Yoko |e verfasserin |4 aut | |
| 700 | 1 | |a Matsunaga, Takuya |e verfasserin |4 aut | |
| 700 | 1 | |a Shimoda, Kazuya |e verfasserin |4 aut | |
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