Risk-adapted treatment of acute promyelocytic leukemia based on all-trans retinoic acid and anthracycline with addition of cytarabine in consolidation therapy for high-risk patients : further improvements in treatment outcome
A risk-adapted strategy based on all-trans retinoic acid (ATRA) and anthracycline monochemotherapy (PETHEMA LPA99 trial) has demonstrated a high antileukemic efficacy in acute promyelocytic leukemia. We designed a new trial (LPA2005) with the objective of achieving stepwise improvements in outcome. Between July 2005 and April 2009, low- and intermediate-risk patients (leukocytes < 10 x 10(9)/L) received a reduced dose of mitoxantrone for the second consolidation course, whereas high- risk patients younger than 60 years of age received cytarabine combined with ATRA and idarubicin in the first and third consolidation courses. Of 372 patients attaining complete remission after ATRA plus idarubicin (92.5%), 368 proceeded to consolidation therapy. For low- and intermediate-risk patients, duration of neutropenia and thrombocytopenia and hospital stay were significantly reduced without sacrificing antileukemic efficacy, compared with the previous LPA99 trial. For high-risk patients, the 3-year relapse rate was significantly lower in the LPA2005 trial (11%) than in the LPA99 (26%; P = .03). Overall disease-free survival was also better in the LPA2005 trial (P = .04). In conclusion, the lower dose of mitoxantrone resulted in a significant reduction of toxicity and hospital stay while maintaining the antileukemic activity, and the combination of ATRA, idarubicin, and cytarabine for high-risk acute promyelocytic leukemia significantly reduced the relapse rate in this setting. Registered at http://www.clinicaltrials.gov as NCT00408278.
Errataetall: |
CommentIn: Nat Rev Clin Oncol. 2010 Sep;7(9):484. - PMID 20824904 |
---|---|
Medienart: |
E-Artikel |
Erscheinungsjahr: |
2010 |
---|---|
Erschienen: |
2010 |
Enthalten in: |
Zur Gesamtaufnahme - volume:115 |
---|---|
Enthalten in: |
Blood - 115(2010), 25 vom: 24. Juni, Seite 5137-46 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Sanz, Miguel A [VerfasserIn] |
---|
Links: |
---|
Themen: |
04079A1RDZ |
---|
Anmerkungen: |
Date Completed 09.07.2010 Date Revised 06.02.2021 published: Print-Electronic ClinicalTrials.gov: NCT00408278 CommentIn: Nat Rev Clin Oncol. 2010 Sep;7(9):484. - PMID 20824904 Citation Status MEDLINE |
---|
doi: |
10.1182/blood-2010-01-266007 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM197358756 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM197358756 | ||
003 | DE-627 | ||
005 | 20231223210402.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231223s2010 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1182/blood-2010-01-266007 |2 doi | |
028 | 5 | 2 | |a pubmed24n0658.xml |
035 | |a (DE-627)NLM197358756 | ||
035 | |a (NLM)20393132 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Sanz, Miguel A |e verfasserin |4 aut | |
245 | 1 | 0 | |a Risk-adapted treatment of acute promyelocytic leukemia based on all-trans retinoic acid and anthracycline with addition of cytarabine in consolidation therapy for high-risk patients |b further improvements in treatment outcome |
264 | 1 | |c 2010 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 09.07.2010 | ||
500 | |a Date Revised 06.02.2021 | ||
500 | |a published: Print-Electronic | ||
500 | |a ClinicalTrials.gov: NCT00408278 | ||
500 | |a CommentIn: Nat Rev Clin Oncol. 2010 Sep;7(9):484. - PMID 20824904 | ||
500 | |a Citation Status MEDLINE | ||
520 | |a A risk-adapted strategy based on all-trans retinoic acid (ATRA) and anthracycline monochemotherapy (PETHEMA LPA99 trial) has demonstrated a high antileukemic efficacy in acute promyelocytic leukemia. We designed a new trial (LPA2005) with the objective of achieving stepwise improvements in outcome. Between July 2005 and April 2009, low- and intermediate-risk patients (leukocytes < 10 x 10(9)/L) received a reduced dose of mitoxantrone for the second consolidation course, whereas high- risk patients younger than 60 years of age received cytarabine combined with ATRA and idarubicin in the first and third consolidation courses. Of 372 patients attaining complete remission after ATRA plus idarubicin (92.5%), 368 proceeded to consolidation therapy. For low- and intermediate-risk patients, duration of neutropenia and thrombocytopenia and hospital stay were significantly reduced without sacrificing antileukemic efficacy, compared with the previous LPA99 trial. For high-risk patients, the 3-year relapse rate was significantly lower in the LPA2005 trial (11%) than in the LPA99 (26%; P = .03). Overall disease-free survival was also better in the LPA2005 trial (P = .04). In conclusion, the lower dose of mitoxantrone resulted in a significant reduction of toxicity and hospital stay while maintaining the antileukemic activity, and the combination of ATRA, idarubicin, and cytarabine for high-risk acute promyelocytic leukemia significantly reduced the relapse rate in this setting. Registered at http://www.clinicaltrials.gov as NCT00408278 | ||
650 | 4 | |a Clinical Trial | |
650 | 4 | |a Journal Article | |
650 | 4 | |a Multicenter Study | |
650 | 4 | |a Research Support, Non-U.S. Gov't | |
650 | 7 | |a Anthracyclines |2 NLM | |
650 | 7 | |a Cytarabine |2 NLM | |
650 | 7 | |a 04079A1RDZ |2 NLM | |
650 | 7 | |a Tretinoin |2 NLM | |
650 | 7 | |a 5688UTC01R |2 NLM | |
700 | 1 | |a Montesinos, Pau |e verfasserin |4 aut | |
700 | 1 | |a Rayón, Chelo |e verfasserin |4 aut | |
700 | 1 | |a Holowiecka, Alexandra |e verfasserin |4 aut | |
700 | 1 | |a de la Serna, Javier |e verfasserin |4 aut | |
700 | 1 | |a Milone, Gustavo |e verfasserin |4 aut | |
700 | 1 | |a de Lisa, Elena |e verfasserin |4 aut | |
700 | 1 | |a Brunet, Salut |e verfasserin |4 aut | |
700 | 1 | |a Rubio, Vicente |e verfasserin |4 aut | |
700 | 1 | |a Ribera, José M |e verfasserin |4 aut | |
700 | 1 | |a Rivas, Concha |e verfasserin |4 aut | |
700 | 1 | |a Krsnik, Isabel |e verfasserin |4 aut | |
700 | 1 | |a Bergua, Juan |e verfasserin |4 aut | |
700 | 1 | |a González, José |e verfasserin |4 aut | |
700 | 1 | |a Díaz-Mediavilla, Joaquín |e verfasserin |4 aut | |
700 | 1 | |a Rojas, Rafael |e verfasserin |4 aut | |
700 | 1 | |a Manso, Félix |e verfasserin |4 aut | |
700 | 1 | |a Ossenkoppele, Gert |e verfasserin |4 aut | |
700 | 1 | |a González, José D |e verfasserin |4 aut | |
700 | 1 | |a Lowenberg, Bob |e verfasserin |4 aut | |
700 | 0 | |a PETHEMA and HOVON Groups |e verfasserin |4 aut | |
700 | 1 | |a de Heredia, J M Beltrán |e investigator |4 oth | |
700 | 1 | |a Hernández, J M |e investigator |4 oth | |
700 | 1 | |a Arias, J |e investigator |4 oth | |
700 | 1 | |a Ramos, F |e investigator |4 oth | |
700 | 1 | |a Román, A |e investigator |4 oth | |
700 | 1 | |a de la Serna, J |e investigator |4 oth | |
700 | 1 | |a Negri, S |e investigator |4 oth | |
700 | 1 | |a Rayón, C |e investigator |4 oth | |
700 | 1 | |a Esteve, J |e investigator |4 oth | |
700 | 1 | |a Fernández-Calvo, F J |e investigator |4 oth | |
700 | 1 | |a Díaz-Mediavilla, J |e investigator |4 oth | |
700 | 1 | |a Gil, C |e investigator |4 oth | |
700 | 1 | |a Pérez-encinas, M |e investigator |4 oth | |
700 | 1 | |a Tormo, M |e investigator |4 oth | |
700 | 1 | |a Olave, M |e investigator |4 oth | |
700 | 1 | |a Amutio, E |e investigator |4 oth | |
700 | 1 | |a Pedro, C |e investigator |4 oth | |
700 | 1 | |a Gorosquieta, A |e investigator |4 oth | |
700 | 1 | |a Viguria, M |e investigator |4 oth | |
700 | 1 | |a Zudaire, M |e investigator |4 oth | |
700 | 1 | |a Molero, T |e investigator |4 oth | |
700 | 1 | |a Sayas, M J |e investigator |4 oth | |
700 | 1 | |a Guardia, R |e investigator |4 oth | |
700 | 1 | |a Manso, F |e investigator |4 oth | |
700 | 1 | |a Rivas, C |e investigator |4 oth | |
700 | 1 | |a Esquembre, C |e investigator |4 oth | |
700 | 1 | |a García, R |e investigator |4 oth | |
700 | 1 | |a Alcalá, A |e investigator |4 oth | |
700 | 1 | |a López, J A |e investigator |4 oth | |
700 | 1 | |a Rubio, V |e investigator |4 oth | |
700 | 1 | |a Amigo, M L |e investigator |4 oth | |
700 | 1 | |a Linares, M |e investigator |4 oth | |
700 | 1 | |a Ribera, J M |e investigator |4 oth | |
700 | 1 | |a San Miguel, J D González |e investigator |4 oth | |
700 | 1 | |a Debén, G |e investigator |4 oth | |
700 | 1 | |a Escoda, L |e investigator |4 oth | |
700 | 1 | |a de la Cámara, R |e investigator |4 oth | |
700 | 1 | |a Molines, A |e investigator |4 oth | |
700 | 1 | |a Loureiro, C |e investigator |4 oth | |
700 | 1 | |a Allegue, M J |e investigator |4 oth | |
700 | 1 | |a Amador, L |e investigator |4 oth | |
700 | 1 | |a Martí, J M |e investigator |4 oth | |
700 | 1 | |a Madero, L |e investigator |4 oth | |
700 | 1 | |a Lassaletta, A |e investigator |4 oth | |
700 | 1 | |a Cabezudo, M |e investigator |4 oth | |
700 | 1 | |a García-Laraña, J |e investigator |4 oth | |
700 | 1 | |a Rojas, R |e investigator |4 oth | |
700 | 1 | |a Ortega, F |e investigator |4 oth | |
700 | 1 | |a Peñarrubia, M J |e investigator |4 oth | |
700 | 1 | |a Puente, F |e investigator |4 oth | |
700 | 1 | |a López-Ibor, B |e investigator |4 oth | |
700 | 1 | |a Brunet, S |e investigator |4 oth | |
700 | 1 | |a Bergua, J M |e investigator |4 oth | |
700 | 1 | |a Ibáñez, J |e investigator |4 oth | |
700 | 1 | |a Sánchez, P |e investigator |4 oth | |
700 | 1 | |a Novo, A |e investigator |4 oth | |
700 | 1 | |a Font, L L |e investigator |4 oth | |
700 | 1 | |a Guinea, J M |e investigator |4 oth | |
700 | 1 | |a Montero, A |e investigator |4 oth | |
700 | 1 | |a González, M |e investigator |4 oth | |
700 | 1 | |a Sanz, M A |e investigator |4 oth | |
700 | 1 | |a Martín, G |e investigator |4 oth | |
700 | 1 | |a Martínez, J |e investigator |4 oth | |
700 | 1 | |a Montesinos, P |e investigator |4 oth | |
700 | 1 | |a Verdeguer, A |e investigator |4 oth | |
700 | 1 | |a García, P |e investigator |4 oth | |
700 | 1 | |a Conde, E |e investigator |4 oth | |
700 | 1 | |a García, J |e investigator |4 oth | |
700 | 1 | |a Capote, F J |e investigator |4 oth | |
700 | 1 | |a Krsnik, I |e investigator |4 oth | |
700 | 1 | |a Bueno, J |e investigator |4 oth | |
700 | 1 | |a Bastida, P |e investigator |4 oth | |
700 | 1 | |a Rubio, A |e investigator |4 oth | |
700 | 1 | |a Fuster, J L |e investigator |4 oth | |
700 | 1 | |a González, J |e investigator |4 oth | |
700 | 1 | |a Pérez, I |e investigator |4 oth | |
700 | 1 | |a Molina, J |e investigator |4 oth | |
700 | 1 | |a Mateos, M C |e investigator |4 oth | |
700 | 1 | |a Ardaiz, M A |e investigator |4 oth | |
700 | 1 | |a Rodríguez-Calvillo, M |e investigator |4 oth | |
700 | 1 | |a Poderós, C |e investigator |4 oth | |
700 | 1 | |a Arnán, M |e investigator |4 oth | |
700 | 1 | |a Duarte, R |e investigator |4 oth | |
700 | 1 | |a Hernández, J A |e investigator |4 oth | |
700 | 1 | |a Díaz-Morfa, M |e investigator |4 oth | |
700 | 1 | |a Martín-Chacón, E |e investigator |4 oth | |
700 | 1 | |a Calvo-Villas, J M |e investigator |4 oth | |
700 | 1 | |a García-Belmonte, D |e investigator |4 oth | |
700 | 1 | |a Hernández-Maraver, D |e investigator |4 oth | |
700 | 1 | |a Ossenkoppele, G J |e investigator |4 oth | |
700 | 1 | |a van der Lelie, J |e investigator |4 oth | |
700 | 1 | |a Lowenberg, B |e investigator |4 oth | |
700 | 1 | |a Sonneveld, P |e investigator |4 oth | |
700 | 1 | |a Zijlmans, M |e investigator |4 oth | |
700 | 1 | |a Vellenga, E |e investigator |4 oth | |
700 | 1 | |a Maertens, J |e investigator |4 oth | |
700 | 1 | |a de Valk, B |e investigator |4 oth | |
700 | 1 | |a Wijermans, P W |e investigator |4 oth | |
700 | 1 | |a de Groot, M R |e investigator |4 oth | |
700 | 1 | |a Schouten, H C |e investigator |4 oth | |
773 | 0 | 8 | |i Enthalten in |t Blood |d 1946 |g 115(2010), 25 vom: 24. Juni, Seite 5137-46 |w (DE-627)NLM000014761 |x 1528-0020 |7 nnns |
773 | 1 | 8 | |g volume:115 |g year:2010 |g number:25 |g day:24 |g month:06 |g pages:5137-46 |
856 | 4 | 0 | |u http://dx.doi.org/10.1182/blood-2010-01-266007 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 115 |j 2010 |e 25 |b 24 |c 06 |h 5137-46 |