Structural development studies of anti-hepatitis C virus agents with a phenanthridinone skeleton
Copyright 2010 Elsevier Ltd. All rights reserved..
A phenanthridinone skeleton was derived from our previous researches on thalidomide and retinoids as a multi-template for generation of anti-viral lead compounds. Structural development studies focusing on anti-hepatitis C virus activity afforded 5-butyl-2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenanthridin-6(5H)-one (10) and 5-butylbenzo[b]phenanthridin-6(5H)-one (39), which showed EC(50) values of approximately 3.7 and 3.2microM, respectively.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2010 |
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| Erschienen: |
2010 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:18 |
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| Enthalten in: |
Bioorganic & medicinal chemistry - 18(2010), 7 vom: 01. Apr., Seite 2402-11 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Nakamura, Masahiko [VerfasserIn] |
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| Links: |
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| Themen: |
Antiviral Agents |
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| Anmerkungen: |
Date Completed 02.07.2010 Date Revised 05.04.2010 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.bmc.2010.02.057 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM196514665 |
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| 520 | |a Copyright 2010 Elsevier Ltd. All rights reserved. | ||
| 520 | |a A phenanthridinone skeleton was derived from our previous researches on thalidomide and retinoids as a multi-template for generation of anti-viral lead compounds. Structural development studies focusing on anti-hepatitis C virus activity afforded 5-butyl-2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenanthridin-6(5H)-one (10) and 5-butylbenzo[b]phenanthridin-6(5H)-one (39), which showed EC(50) values of approximately 3.7 and 3.2microM, respectively | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 7 | |a Antiviral Agents |2 NLM | |
| 650 | 7 | |a Indicators and Reagents |2 NLM | |
| 650 | 7 | |a Phenanthridines |2 NLM | |
| 650 | 7 | |a RNA, Viral |2 NLM | |
| 650 | 7 | |a Glyceraldehyde-3-Phosphate Dehydrogenases |2 NLM | |
| 650 | 7 | |a EC 1.2.1.- |2 NLM | |
| 700 | 1 | |a Aoyama, Atsushi |e verfasserin |4 aut | |
| 700 | 1 | |a Salim, Mohammed T A |e verfasserin |4 aut | |
| 700 | 1 | |a Okamoto, Mika |e verfasserin |4 aut | |
| 700 | 1 | |a Baba, Masanori |e verfasserin |4 aut | |
| 700 | 1 | |a Miyachi, Hiroyuki |e verfasserin |4 aut | |
| 700 | 1 | |a Hashimoto, Yuichi |e verfasserin |4 aut | |
| 700 | 1 | |a Aoyama, Hiroshi |e verfasserin |4 aut | |
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