HIV infection in different age groups : Potential implications for prevention. CoRIS Cohort, Spain, 2004-2008
2009 Elsevier España, S.L. All rights reserved..
BACKGROUND AND OBJECTIVE: To describe the characteristics of HIV infected adults according to their age at recruitment in CoRIS.
PATIENTS AND METHODS: Analysis of an open, prospective, multicentric cohort of HIV+ adults without previous antiretroviral treatment, attended for the first time from January/2004 to November/2008, in 28 Spanish hospitals (CoRIS). We analyzed their characteristics at recruitment and the distribution of AIDS defining illnesses (ADI) prior to cohort entry and during follow up, according to their age at recruitment. Delayed diagnosis was defined as a patient with AIDS diagnosis and/or CD4+ cell count lower than 200 cells/microl within the first year after HIV diagnosis.
RESULTS: Of 4,418 patients included, 30.4% were < or =30 years old, 60.6% between 31 and 50 and 8.9% older than 50 at cohort entry; 31.6% of patients were immigrants (44.1% in the youngest group), 79.6% had been sexually transmitted and 15.2% had an AIDS diagnosis at cohort entry (28.1% between those older than 50). In 34.6% of cases there was a late diagnosis (53.3% in the oldest group). The ADIs varied according to age; tuberculosis was more frequent in the youngest. Pneumocystis jiroveci pneumonia, progressive multifocal leukoencephalopathy, HIV related encephalopathy, recurrent pneumonia and primary lymphoma of brain were more frequent among the oldest.
CONCLUSIONS: The immunological characteristics and the distribution of ADIs varied according to age. The proportion of late diagnosis was unacceptably high, suggesting the need of specific interventions designed to promote earlier diagnosis.
| Errataetall: |
CommentIn: Med Clin (Barc). 2010 May 8;134(13):587-8. - PMID 20207372 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2010 |
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| Erschienen: |
2010 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:134 |
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| Enthalten in: |
Medicina clinica - 134(2010), 12 vom: 24. Apr., Seite 521-7 |
| Sprache: |
Spanisch |
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| Weiterer Titel: |
Infección por el virus de la inmunodeficiencia humana en diferentes grupos de edad: implicaciones potenciales para la prevención. Cohorte CoRIS, España, 2004-2008 |
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| Anmerkungen: |
Date Completed 26.07.2010 Date Revised 10.08.2010 published: Print-Electronic CommentIn: Med Clin (Barc). 2010 May 8;134(13):587-8. - PMID 20207372 Citation Status MEDLINE |
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| doi: |
10.1016/j.medcli.2009.09.053 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM195584449 |
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| 245 | 1 | 0 | |a HIV infection in different age groups |b Potential implications for prevention. CoRIS Cohort, Spain, 2004-2008 |
| 246 | 3 | 3 | |a Infección por el virus de la inmunodeficiencia humana en diferentes grupos de edad: implicaciones potenciales para la prevención. Cohorte CoRIS, España, 2004-2008 |
| 264 | 1 | |c 2010 | |
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| 500 | |a Date Completed 26.07.2010 | ||
| 500 | |a Date Revised 10.08.2010 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a CommentIn: Med Clin (Barc). 2010 May 8;134(13):587-8. - PMID 20207372 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a 2009 Elsevier España, S.L. All rights reserved. | ||
| 520 | |a BACKGROUND AND OBJECTIVE: To describe the characteristics of HIV infected adults according to their age at recruitment in CoRIS | ||
| 520 | |a PATIENTS AND METHODS: Analysis of an open, prospective, multicentric cohort of HIV+ adults without previous antiretroviral treatment, attended for the first time from January/2004 to November/2008, in 28 Spanish hospitals (CoRIS). We analyzed their characteristics at recruitment and the distribution of AIDS defining illnesses (ADI) prior to cohort entry and during follow up, according to their age at recruitment. Delayed diagnosis was defined as a patient with AIDS diagnosis and/or CD4+ cell count lower than 200 cells/microl within the first year after HIV diagnosis | ||
| 520 | |a RESULTS: Of 4,418 patients included, 30.4% were < or =30 years old, 60.6% between 31 and 50 and 8.9% older than 50 at cohort entry; 31.6% of patients were immigrants (44.1% in the youngest group), 79.6% had been sexually transmitted and 15.2% had an AIDS diagnosis at cohort entry (28.1% between those older than 50). In 34.6% of cases there was a late diagnosis (53.3% in the oldest group). The ADIs varied according to age; tuberculosis was more frequent in the youngest. Pneumocystis jiroveci pneumonia, progressive multifocal leukoencephalopathy, HIV related encephalopathy, recurrent pneumonia and primary lymphoma of brain were more frequent among the oldest | ||
| 520 | |a CONCLUSIONS: The immunological characteristics and the distribution of ADIs varied according to age. The proportion of late diagnosis was unacceptably high, suggesting the need of specific interventions designed to promote earlier diagnosis | ||
| 650 | 4 | |a Comparative Study | |
| 650 | 4 | |a English Abstract | |
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| 700 | 1 | |a García, Isabel |e investigator |4 oth | |
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