Immunohistochemical evaluation of inflammatory reaction in a case of pilomatrixoma
OBJECTIVES: To identify the types of the cells in a case of pilomatricoma and to evaluate the lesion's stage, the cells' proliferating rate and the associated inflammatory reaction.
MATERIAL AND METHODS: The paraffin-embedded tissue was investigated by histological examination and by immunohistochemistry for the expression of some markers such as: cytokeratins, CD3, CD20, CD68, PCNA, CD34 II.
RESULTS: The lesion presented the characteristic epithelial cells of a classical pilomatricoma: bazaloid cells, ghost cells and transitional cells. 10-15% of the bazaloid cells were PCNA+. The MNF 116 antibody labeled only some of the transitional and of the ghost cells. We found no CD3-positive cells and few CD20-positive cells. A marked inflammatory reaction was noticed, dominated by giant multinucleated cells, positive for CD68 and PCNA and a rich network of blood vessels with a high vascular density.
CONCLUSION: The histological pilomatricoma diagnosis was straightforward on the basis of the bazaloid and ghost cells presence. Immunohistochemistry brought additional data regarding the cells proliferation rate, the stage of the lesion and the intensity of the associated inflammation.
| Medienart: |
Artikel |
|---|
| Erscheinungsjahr: |
2009 |
|---|---|
| Erschienen: |
2009 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:113 |
|---|---|
| Enthalten in: |
Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi - 113(2009), 3 vom: 08. Juli, Seite 819-25 |
| Sprache: |
Rumänisch |
|---|
| Weiterer Titel: |
Evaluarea prin imunohistochimie a reacţiei inflamatorii intr-un caz de pilomatricom |
|---|
| Beteiligte Personen: |
Indrei, Anca [VerfasserIn] |
|---|
| Anmerkungen: |
Date Completed 06.05.2010 Date Revised 16.11.2017 published: Print Citation Status MEDLINE |
|---|
| Förderinstitution / Projekttitel: |
|
|---|
| PPN (Katalog-ID): |
NLM195436849 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM195436849 | ||
| 003 | DE-627 | ||
| 005 | 20231223202748.0 | ||
| 007 | tu | ||
| 008 | 231223s2009 xx ||||| 00| ||rum c | ||
| 028 | 5 | 2 | |a pubmed24n0651.xml |
| 035 | |a (DE-627)NLM195436849 | ||
| 035 | |a (NLM)20191839 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a rum | ||
| 100 | 1 | |a Indrei, Anca |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Immunohistochemical evaluation of inflammatory reaction in a case of pilomatrixoma |
| 246 | 3 | 3 | |a Evaluarea prin imunohistochimie a reacţiei inflamatorii intr-un caz de pilomatricom |
| 264 | 1 | |c 2009 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a Date Completed 06.05.2010 | ||
| 500 | |a Date Revised 16.11.2017 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVES: To identify the types of the cells in a case of pilomatricoma and to evaluate the lesion's stage, the cells' proliferating rate and the associated inflammatory reaction | ||
| 520 | |a MATERIAL AND METHODS: The paraffin-embedded tissue was investigated by histological examination and by immunohistochemistry for the expression of some markers such as: cytokeratins, CD3, CD20, CD68, PCNA, CD34 II | ||
| 520 | |a RESULTS: The lesion presented the characteristic epithelial cells of a classical pilomatricoma: bazaloid cells, ghost cells and transitional cells. 10-15% of the bazaloid cells were PCNA+. The MNF 116 antibody labeled only some of the transitional and of the ghost cells. We found no CD3-positive cells and few CD20-positive cells. A marked inflammatory reaction was noticed, dominated by giant multinucleated cells, positive for CD68 and PCNA and a rich network of blood vessels with a high vascular density | ||
| 520 | |a CONCLUSION: The histological pilomatricoma diagnosis was straightforward on the basis of the bazaloid and ghost cells presence. Immunohistochemistry brought additional data regarding the cells proliferation rate, the stage of the lesion and the intensity of the associated inflammation | ||
| 650 | 4 | |a Case Reports | |
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Antigens, CD |2 NLM | |
| 650 | 7 | |a Antigens, CD20 |2 NLM | |
| 650 | 7 | |a Antigens, CD34 |2 NLM | |
| 650 | 7 | |a Antigens, Differentiation, Myelomonocytic |2 NLM | |
| 650 | 7 | |a Biomarkers, Tumor |2 NLM | |
| 650 | 7 | |a CD3 Complex |2 NLM | |
| 650 | 7 | |a CD68 antigen, human |2 NLM | |
| 650 | 7 | |a Keratins, Hair-Specific |2 NLM | |
| 650 | 7 | |a Proliferating Cell Nuclear Antigen |2 NLM | |
| 700 | 1 | |a Cianga, P |e verfasserin |4 aut | |
| 700 | 1 | |a Dumitrescu, Gabriela Florenţa |e verfasserin |4 aut | |
| 700 | 1 | |a Cianga, Corina |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi |d 1961 |g 113(2009), 3 vom: 08. Juli, Seite 819-25 |w (DE-627)NLM000103667 |x 0048-7848 |7 nnns |
| 773 | 1 | 8 | |g volume:113 |g year:2009 |g number:3 |g day:08 |g month:07 |g pages:819-25 |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 113 |j 2009 |e 3 |b 08 |c 07 |h 819-25 | ||