High dietary intake of magnesium may decrease risk of colorectal cancer in Japanese men
Magnesium maintains genomic stability and is an essential cofactor for DNA synthesis and repair. Magnesium intake has been reported to be inversely associated with colorectal cancer (CRC) risk in Western populations. This study examined the association between dietary intake of magnesium and CRC risk in Japanese men and women aged 45-74 y. Data from 40,830 men and 46,287 women, at the 5-y follow-up of the Japan Public Health Center-based Prospective Study, who responded to a 138-item FFQ were used in this analysis. A total of 689 and 440 CRC events were observed during the mean follow-up of 7.9 and 8.3 y for men and women, respectively. When adjusted for potential confounders, the hazard ratio and 95% CI in the highest quintile of magnesium intake compared with the lowest quintile in men were 0.65 (95% CI, 0.40-1.03) for CRC (P-trend = 0.04), 0.48 (95% CI, 0.26-0.89) for colon cancer (P-trend = 0.01), and 0.97 (95% CI, 0.47-2.02) for rectal cancer (P-trend = 0.93). Borderline inverse associations were also observed in men who consumed alcohol regularly (P-trend = 0.07) or had a BMI <25 kg/m(2) (P-trend = 0.06). There were similar inverse associations for invasive colon cancer and distal colon cancer. There were no significant associations between magnesium intake and cancer risk in women. Higher dietary intake of magnesium may decrease the risk of CRC in Japanese men.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2010 |
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| Erschienen: |
2010 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:140 |
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| Enthalten in: |
The Journal of nutrition - 140(2010), 4 vom: 17. Apr., Seite 779-85 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ma, Enbo [VerfasserIn] |
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| Links: |
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| Themen: |
I38ZP9992A |
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| Anmerkungen: |
Date Completed 30.04.2010 Date Revised 16.02.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.3945/jn.109.117747 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM195177428 |
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| 041 | |a eng | ||
| 100 | 1 | |a Ma, Enbo |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a High dietary intake of magnesium may decrease risk of colorectal cancer in Japanese men |
| 264 | 1 | |c 2010 | |
| 336 | |a Text |b txt |2 rdacontent | ||
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| 500 | |a Date Revised 16.02.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Magnesium maintains genomic stability and is an essential cofactor for DNA synthesis and repair. Magnesium intake has been reported to be inversely associated with colorectal cancer (CRC) risk in Western populations. This study examined the association between dietary intake of magnesium and CRC risk in Japanese men and women aged 45-74 y. Data from 40,830 men and 46,287 women, at the 5-y follow-up of the Japan Public Health Center-based Prospective Study, who responded to a 138-item FFQ were used in this analysis. A total of 689 and 440 CRC events were observed during the mean follow-up of 7.9 and 8.3 y for men and women, respectively. When adjusted for potential confounders, the hazard ratio and 95% CI in the highest quintile of magnesium intake compared with the lowest quintile in men were 0.65 (95% CI, 0.40-1.03) for CRC (P-trend = 0.04), 0.48 (95% CI, 0.26-0.89) for colon cancer (P-trend = 0.01), and 0.97 (95% CI, 0.47-2.02) for rectal cancer (P-trend = 0.93). Borderline inverse associations were also observed in men who consumed alcohol regularly (P-trend = 0.07) or had a BMI <25 kg/m(2) (P-trend = 0.06). There were similar inverse associations for invasive colon cancer and distal colon cancer. There were no significant associations between magnesium intake and cancer risk in women. Higher dietary intake of magnesium may decrease the risk of CRC in Japanese men | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Magnesium |2 NLM | |
| 650 | 7 | |a I38ZP9992A |2 NLM | |
| 700 | 1 | |a Sasazuki, Shizuka |e verfasserin |4 aut | |
| 700 | 1 | |a Inoue, Manami |e verfasserin |4 aut | |
| 700 | 1 | |a Iwasaki, Motoki |e verfasserin |4 aut | |
| 700 | 1 | |a Sawada, Norie |e verfasserin |4 aut | |
| 700 | 1 | |a Takachi, Ribeka |e verfasserin |4 aut | |
| 700 | 1 | |a Tsugane, Shoichiro |e verfasserin |4 aut | |
| 700 | 0 | |a Japan Public Health Center-based Prospective Study Group |e verfasserin |4 aut | |
| 700 | 1 | |a Tsugane, S |e investigator |4 oth | |
| 700 | 1 | |a Tsugane, S |e investigator |4 oth | |
| 700 | 1 | |a Inoue, M |e investigator |4 oth | |
| 700 | 1 | |a Sobue, T |e investigator |4 oth | |
| 700 | 1 | |a Hanaoka, T |e investigator |4 oth | |
| 700 | 1 | |a Ogata, J |e investigator |4 oth | |
| 700 | 1 | |a Baba, S |e investigator |4 oth | |
| 700 | 1 | |a Mannami, T |e investigator |4 oth | |
| 700 | 1 | |a Okayama, A |e investigator |4 oth | |
| 700 | 1 | |a Kokubo, Y |e investigator |4 oth | |
| 700 | 1 | |a Miyakawa, K |e investigator |4 oth | |
| 700 | 1 | |a Saito, F |e investigator |4 oth | |
| 700 | 1 | |a Koizumi, A |e investigator |4 oth | |
| 700 | 1 | |a Sano, Y |e investigator |4 oth | |
| 700 | 1 | |a Hashimoto, I |e investigator |4 oth | |
| 700 | 1 | |a Ikuta, T |e investigator |4 oth | |
| 700 | 1 | |a Tanaba, Y |e investigator |4 oth | |
| 700 | 1 | |a Miyajima, Y |e investigator |4 oth | |
| 700 | 1 | |a Suzuki, N |e investigator |4 oth | |
| 700 | 1 | |a Nagasawa, S |e investigator |4 oth | |
| 700 | 1 | |a Furusugi, Y |e investigator |4 oth | |
| 700 | 1 | |a Nagai, N |e investigator |4 oth | |
| 700 | 1 | |a Sanada, H |e investigator |4 oth | |
| 700 | 1 | |a Hatayama, Y |e investigator |4 oth | |
| 700 | 1 | |a Kobayashi, F |e investigator |4 oth | |
| 700 | 1 | |a Uchino, H |e investigator |4 oth | |
| 700 | 1 | |a Shirai, Y |e investigator |4 oth | |
| 700 | 1 | |a Kondo, T |e investigator |4 oth | |
| 700 | 1 | |a Sasaki, R |e investigator |4 oth | |
| 700 | 1 | |a Watanabe, Y |e investigator |4 oth | |
| 700 | 1 | |a Miyagawa, Y |e investigator |4 oth | |
| 700 | 1 | |a Kobayashi, Y |e investigator |4 oth | |
| 700 | 1 | |a Machida, M |e investigator |4 oth | |
| 700 | 1 | |a Kishimoto, Y |e investigator |4 oth | |
| 700 | 1 | |a Takara, E |e investigator |4 oth | |
| 700 | 1 | |a Fukuyama, T |e investigator |4 oth | |
| 700 | 1 | |a Kinjo, M |e investigator |4 oth | |
| 700 | 1 | |a Irei, M |e investigator |4 oth | |
| 700 | 1 | |a Sakiyama, H |e investigator |4 oth | |
| 700 | 1 | |a Imoto, K |e investigator |4 oth | |
| 700 | 1 | |a Yazawa, H |e investigator |4 oth | |
| 700 | 1 | |a Seo, T |e investigator |4 oth | |
| 700 | 1 | |a Seiko, A |e investigator |4 oth | |
| 700 | 1 | |a Ito, F |e investigator |4 oth | |
| 700 | 1 | |a Shoji, F |e investigator |4 oth | |
| 700 | 1 | |a Saito, R |e investigator |4 oth | |
| 700 | 1 | |a Murata, A |e investigator |4 oth | |
| 700 | 1 | |a Minato, K |e investigator |4 oth | |
| 700 | 1 | |a Motegi, K |e investigator |4 oth | |
| 700 | 1 | |a Fujieda, T |e investigator |4 oth | |
| 700 | 1 | |a Abe, T |e investigator |4 oth | |
| 700 | 1 | |a Katagiri, M |e investigator |4 oth | |
| 700 | 1 | |a Suzuki, M |e investigator |4 oth | |
| 700 | 1 | |a Matsui, K |e investigator |4 oth | |
| 700 | 1 | |a Doi, M |e investigator |4 oth | |
| 700 | 1 | |a Terao, A |e investigator |4 oth | |
| 700 | 1 | |a Ishikawa, Y |e investigator |4 oth | |
| 700 | 1 | |a Tagami, T |e investigator |4 oth | |
| 700 | 1 | |a Doi, H |e investigator |4 oth | |
| 700 | 1 | |a Urata, M |e investigator |4 oth | |
| 700 | 1 | |a Okamoto, N |e investigator |4 oth | |
| 700 | 1 | |a Ide, F |e investigator |4 oth | |
| 700 | 1 | |a Sueta, H |e investigator |4 oth | |
| 700 | 1 | |a Sakiyama, H |e investigator |4 oth | |
| 700 | 1 | |a Onga, N |e investigator |4 oth | |
| 700 | 1 | |a Takaesu, H |e investigator |4 oth | |
| 700 | 1 | |a Uehara, M |e investigator |4 oth | |
| 700 | 1 | |a Horii, F |e investigator |4 oth | |
| 700 | 1 | |a Asano, I |e investigator |4 oth | |
| 700 | 1 | |a Yamaguchi, H |e investigator |4 oth | |
| 700 | 1 | |a Aoki, K |e investigator |4 oth | |
| 700 | 1 | |a Maruyama, S |e investigator |4 oth | |
| 700 | 1 | |a Ichii, M |e investigator |4 oth | |
| 700 | 1 | |a Takano, M |e investigator |4 oth | |
| 700 | 1 | |a Matsushima, S |e investigator |4 oth | |
| 700 | 1 | |a Natsukawa, S |e investigator |4 oth | |
| 700 | 1 | |a Akabane, M |e investigator |4 oth | |
| 700 | 1 | |a Konishi, M |e investigator |4 oth | |
| 700 | 1 | |a Okada, K |e investigator |4 oth | |
| 700 | 1 | |a Saito, I |e investigator |4 oth | |
| 700 | 1 | |a Iso, H |e investigator |4 oth | |
| 700 | 1 | |a Honda, Y |e investigator |4 oth | |
| 700 | 1 | |a Yamagishi, K |e investigator |4 oth | |
| 700 | 1 | |a Sakurai, S |e investigator |4 oth | |
| 700 | 1 | |a Tsuchiya, N |e investigator |4 oth | |
| 700 | 1 | |a Sugimura, H |e investigator |4 oth | |
| 700 | 1 | |a Tsubono, Y |e investigator |4 oth | |
| 700 | 1 | |a Kabuto, M |e investigator |4 oth | |
| 700 | 1 | |a Tominaga, S |e investigator |4 oth | |
| 700 | 1 | |a Iida, M |e investigator |4 oth | |
| 700 | 1 | |a Ajiki, W |e investigator |4 oth | |
| 700 | 1 | |a Ioka, A |e investigator |4 oth | |
| 700 | 1 | |a Sato, S |e investigator |4 oth | |
| 700 | 1 | |a Yasuda, N |e investigator |4 oth | |
| 700 | 1 | |a Nakamura, K |e investigator |4 oth | |
| 700 | 1 | |a Kono, S |e investigator |4 oth | |
| 700 | 1 | |a Suzuki, K |e investigator |4 oth | |
| 700 | 1 | |a Takashima, Y |e investigator |4 oth | |
| 700 | 1 | |a Yoshida, M |e investigator |4 oth | |
| 700 | 1 | |a Maruyama, E |e investigator |4 oth | |
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