Transient early-life forebrain corticotropin-releasing hormone elevation causes long-lasting anxiogenic and despair-like changes in mice
During development, early-life stress, such as abuse or trauma, induces long-lasting changes that are linked to adult anxiety and depressive behavior. It has been postulated that altered expression of corticotropin-releasing hormone (CRH) can at least partially account for the various effects of stress on behavior. In accord with this hypothesis, evidence from pharmacological and genetic studies has indicated the capacity of differing levels of CRH activity in different brain areas to produce behavioral changes. Furthermore, stress during early life or adulthood causes an increase in CRH release in a variety of neural sites. To evaluate the temporal and spatial specificity of the effect of early-life CRH exposure on adult behavior, the tetracycline-off system was used to produce mice with forebrain-restricted inducible expression of CRH. After transient elevation of CRH during development only, behavioral testing in adult mice revealed a persistent anxiogenic and despair-like phenotype. These behavioral changes were not associated with alterations in adult circadian or stress-induced corticosterone release but were associated with changes in CRH receptor type 1 expression. Furthermore, the despair-like changes were normalized with antidepressant treatment. Overall, these studies suggest that forebrain-restricted CRH signaling during development can permanently alter stress adaptation leading to increases in maladaptive behavior in adulthood.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2010 |
|---|---|
| Erschienen: |
2010 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:30 |
|---|---|
| Enthalten in: |
The Journal of neuroscience : the official journal of the Society for Neuroscience - 30(2010), 7 vom: 17. Feb., Seite 2571-81 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Kolber, Benedict J [VerfasserIn] |
|---|
| Links: |
|---|
| Anmerkungen: |
Date Completed 19.03.2010 Date Revised 20.10.2021 published: Print Citation Status MEDLINE |
|---|
| doi: |
10.1523/JNEUROSCI.4470-09.2010 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM195177126 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM195177126 | ||
| 003 | DE-627 | ||
| 005 | 20231223202231.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231223s2010 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1523/JNEUROSCI.4470-09.2010 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n0651.xml |
| 035 | |a (DE-627)NLM195177126 | ||
| 035 | |a (NLM)20164342 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Kolber, Benedict J |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Transient early-life forebrain corticotropin-releasing hormone elevation causes long-lasting anxiogenic and despair-like changes in mice |
| 264 | 1 | |c 2010 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 19.03.2010 | ||
| 500 | |a Date Revised 20.10.2021 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a During development, early-life stress, such as abuse or trauma, induces long-lasting changes that are linked to adult anxiety and depressive behavior. It has been postulated that altered expression of corticotropin-releasing hormone (CRH) can at least partially account for the various effects of stress on behavior. In accord with this hypothesis, evidence from pharmacological and genetic studies has indicated the capacity of differing levels of CRH activity in different brain areas to produce behavioral changes. Furthermore, stress during early life or adulthood causes an increase in CRH release in a variety of neural sites. To evaluate the temporal and spatial specificity of the effect of early-life CRH exposure on adult behavior, the tetracycline-off system was used to produce mice with forebrain-restricted inducible expression of CRH. After transient elevation of CRH during development only, behavioral testing in adult mice revealed a persistent anxiogenic and despair-like phenotype. These behavioral changes were not associated with alterations in adult circadian or stress-induced corticosterone release but were associated with changes in CRH receptor type 1 expression. Furthermore, the despair-like changes were normalized with antidepressant treatment. Overall, these studies suggest that forebrain-restricted CRH signaling during development can permanently alter stress adaptation leading to increases in maladaptive behavior in adulthood | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 7 | |a Antidepressive Agents |2 NLM | |
| 650 | 7 | |a Receptors, Corticotropin-Releasing Hormone |2 NLM | |
| 650 | 7 | |a CRF receptor type 1 |2 NLM | |
| 650 | 7 | |a 5CLY6W2H1M |2 NLM | |
| 650 | 7 | |a Growth Hormone |2 NLM | |
| 650 | 7 | |a 9002-72-6 |2 NLM | |
| 650 | 7 | |a Corticotropin-Releasing Hormone |2 NLM | |
| 650 | 7 | |a 9015-71-8 |2 NLM | |
| 650 | 7 | |a Calcium-Calmodulin-Dependent Protein Kinase Type 2 |2 NLM | |
| 650 | 7 | |a EC 2.7.11.17 |2 NLM | |
| 650 | 7 | |a Doxycycline |2 NLM | |
| 650 | 7 | |a N12000U13O |2 NLM | |
| 650 | 7 | |a Imipramine |2 NLM | |
| 650 | 7 | |a OGG85SX4E4 |2 NLM | |
| 700 | 1 | |a Boyle, Maureen P |e verfasserin |4 aut | |
| 700 | 1 | |a Wieczorek, Lindsay |e verfasserin |4 aut | |
| 700 | 1 | |a Kelley, Crystal L |e verfasserin |4 aut | |
| 700 | 1 | |a Onwuzurike, Chiamaka C |e verfasserin |4 aut | |
| 700 | 1 | |a Nettles, Sabin A |e verfasserin |4 aut | |
| 700 | 1 | |a Vogt, Sherri K |e verfasserin |4 aut | |
| 700 | 1 | |a Muglia, Louis J |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The Journal of neuroscience : the official journal of the Society for Neuroscience |d 1993 |g 30(2010), 7 vom: 17. Feb., Seite 2571-81 |w (DE-627)NLM01259184X |x 1529-2401 |7 nnns |
| 773 | 1 | 8 | |g volume:30 |g year:2010 |g number:7 |g day:17 |g month:02 |g pages:2571-81 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1523/JNEUROSCI.4470-09.2010 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 30 |j 2010 |e 7 |b 17 |c 02 |h 2571-81 | ||