Monitoring of haemocoagulative changes during long-term doses of low molecular weight heparin during pregnancy
OBJECTIVE: The aim of study was to compare plasma levels of selected coagulation parameters in pregnant women with long-term administration of low molecular weight heparin (LMWH) versus cohort of healthy women LMWHs untreated.
DESIGN: Prospective study.
SETTING: Department of Haematology, Institute of Clinical Biochemistry and Haematology, Charles University and University Hospital, Plzen.
METHODS: We examined 67 pregnant women with recurrent fetal loss in previous pregnant history treated by long-term prophylactic administration of LMWH. Blood samples were collected before gestation and at 10th, 20th, 30th gestational weeks.
RESULTS: Pregnant women with own history of recurrent fetal loss treated by the long-term prophylactic dose of LMWHs during pregnancy have the same values of the coagulation parameters as the control cohort in spite of fact that the clinical efficacy of administered LMWHs is high.
CONCLUSION: Our results suggest that heparin may act by many unknown different mechanisms, such as inhibition of complement binding or secretion of prostaglandins.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2009 |
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| Erschienen: |
2009 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:74 |
|---|---|
| Enthalten in: |
Ceska gynekologie - 74(2009), 5 vom: 01. Okt., Seite 348-54 |
| Sprache: |
Tschechisch |
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| Weiterer Titel: |
Sledování hemokoagulacních zmen v průbehu tehotenství zen s opakovaným potrácením v závislosti na podávání nízkomolekulárního heparinu |
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| Beteiligte Personen: |
Sigutová, P [VerfasserIn] |
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| Themen: |
Anticoagulants |
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| Anmerkungen: |
Date Completed 29.01.2010 Date Revised 06.12.2016 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM194260682 |
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| 041 | |a cze | ||
| 100 | 1 | |a Sigutová, P |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Monitoring of haemocoagulative changes during long-term doses of low molecular weight heparin during pregnancy |
| 246 | 3 | 3 | |a Sledování hemokoagulacních zmen v průbehu tehotenství zen s opakovaným potrácením v závislosti na podávání nízkomolekulárního heparinu |
| 264 | 1 | |c 2009 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a Date Completed 29.01.2010 | ||
| 500 | |a Date Revised 06.12.2016 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVE: The aim of study was to compare plasma levels of selected coagulation parameters in pregnant women with long-term administration of low molecular weight heparin (LMWH) versus cohort of healthy women LMWHs untreated | ||
| 520 | |a DESIGN: Prospective study | ||
| 520 | |a SETTING: Department of Haematology, Institute of Clinical Biochemistry and Haematology, Charles University and University Hospital, Plzen | ||
| 520 | |a METHODS: We examined 67 pregnant women with recurrent fetal loss in previous pregnant history treated by long-term prophylactic administration of LMWH. Blood samples were collected before gestation and at 10th, 20th, 30th gestational weeks | ||
| 520 | |a RESULTS: Pregnant women with own history of recurrent fetal loss treated by the long-term prophylactic dose of LMWHs during pregnancy have the same values of the coagulation parameters as the control cohort in spite of fact that the clinical efficacy of administered LMWHs is high | ||
| 520 | |a CONCLUSION: Our results suggest that heparin may act by many unknown different mechanisms, such as inhibition of complement binding or secretion of prostaglandins | ||
| 650 | 4 | |a English Abstract | |
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Anticoagulants |2 NLM | |
| 650 | 7 | |a Blood Coagulation Factors |2 NLM | |
| 650 | 7 | |a Heparin, Low-Molecular-Weight |2 NLM | |
| 700 | 1 | |a Hajsmanová, Z |e verfasserin |4 aut | |
| 700 | 1 | |a Slechtová, J |e verfasserin |4 aut | |
| 700 | 1 | |a Subrt, I |e verfasserin |4 aut | |
| 700 | 1 | |a Hradecký, L |e verfasserin |4 aut | |
| 700 | 1 | |a Ulcová-Gallová, Z |e verfasserin |4 aut | |
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