Design, synthesis, inhibitory activity, and binding mode study of novel DNA methyltransferase 1 inhibitors
Copyright (c) 2009 Elsevier Ltd. All rights reserved..
To identify novel non-nucleoside DNA methyltransferase (DNMT) inhibitors, we designed and synthesized a series of maleimide derivatives. Among this series, compounds 5-8 were found to be more potent DNMT1 inhibitors than RG108, a DNMT1 inhibitor reported previously by Siedlecki et al. The binding mode analysis of compound 5 is also reported.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2010 |
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| Erschienen: |
2010 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:20 |
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| Enthalten in: |
Bioorganic & medicinal chemistry letters - 20(2010), 3 vom: 01. Feb., Seite 1124-7 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Suzuki, Takayoshi [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 20.09.2010 Date Revised 16.11.2017 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.bmcl.2009.12.016 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM194191249 |
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| 245 | 1 | 0 | |a Design, synthesis, inhibitory activity, and binding mode study of novel DNA methyltransferase 1 inhibitors |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright (c) 2009 Elsevier Ltd. All rights reserved. | ||
| 520 | |a To identify novel non-nucleoside DNA methyltransferase (DNMT) inhibitors, we designed and synthesized a series of maleimide derivatives. Among this series, compounds 5-8 were found to be more potent DNMT1 inhibitors than RG108, a DNMT1 inhibitor reported previously by Siedlecki et al. The binding mode analysis of compound 5 is also reported | ||
| 650 | 4 | |a Comparative Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Indoles |2 NLM | |
| 650 | 7 | |a Maleimides |2 NLM | |
| 650 | 7 | |a Phthalimides |2 NLM | |
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| 650 | 7 | |a RG108 |2 NLM | |
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| 700 | 1 | |a Tanaka, Rikako |e verfasserin |4 aut | |
| 700 | 1 | |a Hamada, Shohei |e verfasserin |4 aut | |
| 700 | 1 | |a Nakagawa, Hidehiko |e verfasserin |4 aut | |
| 700 | 1 | |a Miyata, Naoki |e verfasserin |4 aut | |
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