Efficacy and safety of 2-hour urokinase regime in acute pulmonary embolism : a randomized controlled trial
BACKGROUNDS: Urokinase (UK) 2 200 U/kg.h for 12 hours infusion(UK-12 h)is an ACCP recommended regimen in treating acute pulmonary embolism (PE). It is unclear whether this dose and time can be reduced further. We compared the efficacy and safety of 20, 000 U/kg for 2 hours (UK-2 h) with the UK-12 h regime in selected PE patients.
METHODS: A randomized trial involving 129 patients was conducted. Patients with acute PE were randomly assigned to receive either UK-12 h (n = 70), or UK-2 h (n = 59). The efficacy was determined by the improvement of right heart dysfunction and perfusion defect at 24 h and 14 d post UK treatment. The bleeding incidence, death rate and PE recurrence were also evaluated.
RESULTS: Similarly significant improvements in right heart dysfunction and lung perfusion defects were observed in both groups. Overall bleeding incidents were low in both groups. Major bleeding directly associated with UK infusion occurred in one patient in the UK-2 h group and one in the UK-12 h group. Mortality rates were low, with one reported fatal recurrent in the UK-12 h group and none in the UK-2 h group. When the rate of bleeding, death and PE recurrence were compared separately in the hemodynamic instability and the massive anatomic obstruction subgroups, no significant difference was found.
CONCLUSIONS: The UK-2 h regimen exhibits similar efficacy and safety as the UK-12 h regimen for acute PE.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2009 |
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| Erschienen: |
2009 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:10 |
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| Enthalten in: |
Respiratory research - 10(2009) vom: 29. Dez., Seite 128 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Wang, Chen [VerfasserIn] |
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| Links: |
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| Themen: |
EC 3.4.21.73 |
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| Anmerkungen: |
Date Completed 02.03.2010 Date Revised 20.10.2021 published: Electronic ClinicalTrials.gov: NCT00799968 Citation Status MEDLINE |
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| doi: |
10.1186/1465-9921-10-128 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM194035093 |
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| 100 | 1 | |a Wang, Chen |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Efficacy and safety of 2-hour urokinase regime in acute pulmonary embolism |b a randomized controlled trial |
| 264 | 1 | |c 2009 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
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| 500 | |a Date Completed 02.03.2010 | ||
| 500 | |a Date Revised 20.10.2021 | ||
| 500 | |a published: Electronic | ||
| 500 | |a ClinicalTrials.gov: NCT00799968 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUNDS: Urokinase (UK) 2 200 U/kg.h for 12 hours infusion(UK-12 h)is an ACCP recommended regimen in treating acute pulmonary embolism (PE). It is unclear whether this dose and time can be reduced further. We compared the efficacy and safety of 20, 000 U/kg for 2 hours (UK-2 h) with the UK-12 h regime in selected PE patients | ||
| 520 | |a METHODS: A randomized trial involving 129 patients was conducted. Patients with acute PE were randomly assigned to receive either UK-12 h (n = 70), or UK-2 h (n = 59). The efficacy was determined by the improvement of right heart dysfunction and perfusion defect at 24 h and 14 d post UK treatment. The bleeding incidence, death rate and PE recurrence were also evaluated | ||
| 520 | |a RESULTS: Similarly significant improvements in right heart dysfunction and lung perfusion defects were observed in both groups. Overall bleeding incidents were low in both groups. Major bleeding directly associated with UK infusion occurred in one patient in the UK-2 h group and one in the UK-12 h group. Mortality rates were low, with one reported fatal recurrent in the UK-12 h group and none in the UK-2 h group. When the rate of bleeding, death and PE recurrence were compared separately in the hemodynamic instability and the massive anatomic obstruction subgroups, no significant difference was found | ||
| 520 | |a CONCLUSIONS: The UK-2 h regimen exhibits similar efficacy and safety as the UK-12 h regimen for acute PE | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Randomized Controlled Trial | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Fibrinolytic Agents |2 NLM | |
| 650 | 7 | |a Urokinase-Type Plasminogen Activator |2 NLM | |
| 650 | 7 | |a EC 3.4.21.73 |2 NLM | |
| 700 | 1 | |a Zhai, Zhenguo |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Yuanhua |e verfasserin |4 aut | |
| 700 | 1 | |a Yuan, Yadong |e verfasserin |4 aut | |
| 700 | 1 | |a Cheng, Zhaozhong |e verfasserin |4 aut | |
| 700 | 1 | |a Liang, Lirong |e verfasserin |4 aut | |
| 700 | 1 | |a Dai, Huaping |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Kewu |e verfasserin |4 aut | |
| 700 | 1 | |a Lu, Weixuan |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Zhonghe |e verfasserin |4 aut | |
| 700 | 1 | |a Cheng, Xiansheng |e verfasserin |4 aut | |
| 700 | 1 | |a Shen, Ying H |e verfasserin |4 aut | |
| 700 | 0 | |a China Venous Thromboembolism Study Group |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Chen |e investigator |4 oth | |
| 700 | 1 | |a Cheng, Xiansheng |e investigator |4 oth | |
| 700 | 1 | |a Weng, Xinzhi |e investigator |4 oth | |
| 700 | 1 | |a Lu, Weixuan |e investigator |4 oth | |
| 700 | 1 | |a He, Quanying |e investigator |4 oth | |
| 700 | 1 | |a Zhao, Yiming |e investigator |4 oth | |
| 700 | 1 | |a Ma, Binrong |e investigator |4 oth | |
| 700 | 1 | |a Zhong, Nanshan |e investigator |4 oth | |
| 700 | 1 | |a Cheng, Xiansheng |e investigator |4 oth | |
| 700 | 1 | |a Dai, Ruping |e investigator |4 oth | |
| 700 | 1 | |a Guo, Youmin |e investigator |4 oth | |
| 700 | 1 | |a Wang, Tie |e investigator |4 oth | |
| 700 | 1 | |a Lu, Weixuan |e investigator |4 oth | |
| 700 | 1 | |a He, Quanying |e investigator |4 oth | |
| 700 | 1 | |a Zhao, Yiming |e investigator |4 oth | |
| 700 | 1 | |a Wang, Chen |e investigator |4 oth | |
| 700 | 1 | |a Yang, Yuanhua |e investigator |4 oth | |
| 700 | 1 | |a Zhai, Zhenguo |e investigator |4 oth | |
| 700 | 1 | |a Liang, Lirong |e investigator |4 oth | |
| 700 | 1 | |a Wang, Chen |e investigator |4 oth | |
| 700 | 1 | |a Yang, Yuanhua |e investigator |4 oth | |
| 700 | 1 | |a Zhai, Zhenguo |e investigator |4 oth | |
| 700 | 1 | |a Pang, Baosen |e investigator |4 oth | |
| 700 | 1 | |a Wu, Yafeng |e investigator |4 oth | |
| 700 | 1 | |a Wang, Xiaojuan |e investigator |4 oth | |
| 700 | 1 | |a Wang, Tie |e investigator |4 oth | |
| 700 | 1 | |a Zhang, Lei |e investigator |4 oth | |
| 700 | 1 | |a Deng, Xin |e investigator |4 oth | |
| 700 | 1 | |a Huang, Kewu |e investigator |4 oth | |
| 700 | 1 | |a Dai, Huaping |e investigator |4 oth | |
| 700 | 1 | |a Tong, Zhaohui |e investigator |4 oth | |
| 700 | 1 | |a Yuan, Yadong |e investigator |4 oth | |
| 700 | 1 | |a Wang, Baofa |e investigator |4 oth | |
| 700 | 1 | |a Cheng, Zhaozhong |e investigator |4 oth | |
| 700 | 1 | |a Jiang, Handong |e investigator |4 oth | |
| 700 | 1 | |a Du, Yongcheng |e investigator |4 oth | |
| 700 | 1 | |a Xu, Jianying |e investigator |4 oth | |
| 700 | 1 | |a Hu, Xiaoyun |e investigator |4 oth | |
| 700 | 1 | |a Ying, Kejing |e investigator |4 oth | |
| 700 | 1 | |a Chen, Liying |e investigator |4 oth | |
| 700 | 1 | |a Xie, Canmao |e investigator |4 oth | |
| 700 | 1 | |a Zeng, Man |e investigator |4 oth | |
| 700 | 1 | |a Chen, Yiqiang |e investigator |4 oth | |
| 700 | 1 | |a Guo, Shenglan |e investigator |4 oth | |
| 700 | 1 | |a Liu, Tangwei |e investigator |4 oth | |
| 700 | 1 | |a Zhong, Nanshan |e investigator |4 oth | |
| 700 | 1 | |a Chen, Rongchang |e investigator |4 oth | |
| 700 | 1 | |a Wu, Hua |e investigator |4 oth | |
| 700 | 1 | |a Sun, Yongchang |e investigator |4 oth | |
| 700 | 1 | |a Yao, Wanzhen |e investigator |4 oth | |
| 700 | 1 | |a Chen, Shaoxian |e investigator |4 oth | |
| 700 | 1 | |a Xie, Yupeng |e investigator |4 oth | |
| 700 | 1 | |a Zhang, Jin |e investigator |4 oth | |
| 700 | 1 | |a Zheng, Xiwei |e investigator |4 oth | |
| 700 | 1 | |a Liu, Zhuola |e investigator |4 oth | |
| 700 | 1 | |a Wang, Xu |e investigator |4 oth | |
| 700 | 1 | |a Lu, Weixuan |e investigator |4 oth | |
| 700 | 1 | |a Liu, Chunping |e investigator |4 oth | |
| 700 | 1 | |a Liu, Yongjian |e investigator |4 oth | |
| 700 | 1 | |a Ma, Zhuang |e investigator |4 oth | |
| 700 | 1 | |a Chen, Ping |e investigator |4 oth | |
| 700 | 1 | |a Liu, Lei |e investigator |4 oth | |
| 700 | 1 | |a Duan, Yunyou |e investigator |4 oth | |
| 700 | 1 | |a Nie, Zhoushan |e investigator |4 oth | |
| 700 | 1 | |a Gao, He |e investigator |4 oth | |
| 700 | 1 | |a Zhang, Bo |e investigator |4 oth | |
| 700 | 1 | |a Fang, Baomin |e investigator |4 oth | |
| 700 | 1 | |a Sun, Tieying |e investigator |4 oth | |
| 700 | 1 | |a Yang, Xiaohong |e investigator |4 oth | |
| 700 | 1 | |a Wu, Dawei |e investigator |4 oth | |
| 700 | 1 | |a Xue, Yuwen |e investigator |4 oth | |
| 700 | 1 | |a Tang, Yan |e investigator |4 oth | |
| 700 | 1 | |a Chen, Shengwen |e investigator |4 oth | |
| 700 | 1 | |a Qiu, Chen |e investigator |4 oth | |
| 700 | 1 | |a Kang, Jian |e investigator |4 oth | |
| 700 | 1 | |a Tian, Lili |e investigator |4 oth | |
| 700 | 1 | |a Lin, Aijun |e investigator |4 oth | |
| 700 | 1 | |a Wang, You |e investigator |4 oth | |
| 700 | 1 | |a Liu, Huilin |e investigator |4 oth | |
| 700 | 1 | |a Zhang, Yingqi |e investigator |4 oth | |
| 700 | 1 | |a Wu, Qi |e investigator |4 oth | |
| 700 | 1 | |a Yin, Yanling |e investigator |4 oth | |
| 700 | 1 | |a Zhou, Wei |e investigator |4 oth | |
| 700 | 1 | |a Li, Shuhua |e investigator |4 oth | |
| 700 | 1 | |a He, Zhengyi |e investigator |4 oth | |
| 700 | 1 | |a Liu, Yuxiang |e investigator |4 oth | |
| 700 | 1 | |a Liu, Xinrong |e investigator |4 oth | |
| 700 | 1 | |a Wang, Hongyang |e investigator |4 oth | |
| 700 | 1 | |a Bai, Ming |e investigator |4 oth | |
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