Novel neuronal proteolipid protein isoforms encoded by the human myelin proteolipid protein 1 gene
Copyright (c) 2010 IBRO. Published by Elsevier Ltd. All rights reserved..
The human myelin proteolipid protein 1 gene (hPLP1), which encodes the major structural myelin proteins of the central nervous system (CNS), is classically described as expressed in the oligodendrocytes, the CNS myelinating cells. We identified two new exons in the intron 1 of the hPLP1 gene that lead to the expression of additional mRNA and protein isoforms mainly expressed in neurons instead of oligodendrocytes. Those novel neuronal PLP isoforms are detected as soon as human fetal development and their concomitant expression is specific of the human species. As classical PLP proteins, the novel protein isoforms seem to be addressed to the plasma membrane. These results suggest for the first time that PLP may have functions in humans not only in oligodendrocytes but also in neurons and could be implicated in axono-glial communication. Moreover, this neuronal expression of the hPLP1 gene might explain the neuronal dysfunctions in patients carrying hPLP1 gene mutations.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2010 |
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| Erschienen: |
2010 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:166 |
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| Enthalten in: |
Neuroscience - 166(2010), 2 vom: 17. März, Seite 522-38 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Sarret, C [VerfasserIn] |
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| Links: |
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| Themen: |
Journal Article |
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| Anmerkungen: |
Date Completed 03.05.2010 Date Revised 17.02.2010 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.neuroscience.2009.12.047 |
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| 245 | 1 | 0 | |a Novel neuronal proteolipid protein isoforms encoded by the human myelin proteolipid protein 1 gene |
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| 500 | |a Date Revised 17.02.2010 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright (c) 2010 IBRO. Published by Elsevier Ltd. All rights reserved. | ||
| 520 | |a The human myelin proteolipid protein 1 gene (hPLP1), which encodes the major structural myelin proteins of the central nervous system (CNS), is classically described as expressed in the oligodendrocytes, the CNS myelinating cells. We identified two new exons in the intron 1 of the hPLP1 gene that lead to the expression of additional mRNA and protein isoforms mainly expressed in neurons instead of oligodendrocytes. Those novel neuronal PLP isoforms are detected as soon as human fetal development and their concomitant expression is specific of the human species. As classical PLP proteins, the novel protein isoforms seem to be addressed to the plasma membrane. These results suggest for the first time that PLP may have functions in humans not only in oligodendrocytes but also in neurons and could be implicated in axono-glial communication. Moreover, this neuronal expression of the hPLP1 gene might explain the neuronal dysfunctions in patients carrying hPLP1 gene mutations | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 7 | |a Protein Isoforms |2 NLM | |
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| 700 | 1 | |a Combes, P |e verfasserin |4 aut | |
| 700 | 1 | |a Micheau, P |e verfasserin |4 aut | |
| 700 | 1 | |a Gelot, A |e verfasserin |4 aut | |
| 700 | 1 | |a Boespflug-Tanguy, O |e verfasserin |4 aut | |
| 700 | 1 | |a Vaurs-Barriere, C |e verfasserin |4 aut | |
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