Cushing's syndrome induced by combined treatment with inhaled fluticasone and oral ritonavir
INTRODUCTION: Fluticasone is a corticosteroid drug which is used in inhaled and nasal formulations for the treatment of asthma and allergic rhinitis. It is metabolized in the liver by the cytochrome P450. Ritonavir, an inhibitor of the HIV protease, also acts as an inhibitor of several isoenzymes of the P450 cytochrome. This property explains the many drug interactions observed with this agent.
CASE REPORT: We report two cases of Cushing's syndrome with adrenal insufficiency associated with the combined administration of oral low dose ritonavir and moderate to high dose inhaled fluticasone.
CONCLUSION: These observations highlight the fact that the combined administration of fluticasone and ritonavir must be avoided as well as the combined administration of fluticasone and other inhibitors of the cytochrome P450.
| Medienart: |
Artikel |
|---|
| Erscheinungsjahr: |
2009 |
|---|---|
| Erschienen: |
2009 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:26 |
|---|---|
| Enthalten in: |
Revue des maladies respiratoires - 26(2009), 7 vom: 27. Sept., Seite 779-82 |
| Sprache: |
Französisch |
|---|
| Weiterer Titel: |
Syndrome de Cushing induit par la prise concomitante de fluticasone et de ritonavir |
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| Beteiligte Personen: |
Dupont, C [VerfasserIn] |
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| Themen: |
Androstadienes |
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| Anmerkungen: |
Date Completed 15.01.2010 Date Revised 27.10.2019 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM193197561 |
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| 245 | 1 | 0 | |a Cushing's syndrome induced by combined treatment with inhaled fluticasone and oral ritonavir |
| 246 | 3 | 3 | |a Syndrome de Cushing induit par la prise concomitante de fluticasone et de ritonavir |
| 264 | 1 | |c 2009 | |
| 336 | |a Text |b txt |2 rdacontent | ||
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| 500 | |a Date Completed 15.01.2010 | ||
| 500 | |a Date Revised 27.10.2019 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a INTRODUCTION: Fluticasone is a corticosteroid drug which is used in inhaled and nasal formulations for the treatment of asthma and allergic rhinitis. It is metabolized in the liver by the cytochrome P450. Ritonavir, an inhibitor of the HIV protease, also acts as an inhibitor of several isoenzymes of the P450 cytochrome. This property explains the many drug interactions observed with this agent | ||
| 520 | |a CASE REPORT: We report two cases of Cushing's syndrome with adrenal insufficiency associated with the combined administration of oral low dose ritonavir and moderate to high dose inhaled fluticasone | ||
| 520 | |a CONCLUSION: These observations highlight the fact that the combined administration of fluticasone and ritonavir must be avoided as well as the combined administration of fluticasone and other inhibitors of the cytochrome P450 | ||
| 650 | 4 | |a Case Reports | |
| 650 | 4 | |a English Abstract | |
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Androstadienes |2 NLM | |
| 650 | 7 | |a Bronchodilator Agents |2 NLM | |
| 650 | 7 | |a HIV Protease Inhibitors |2 NLM | |
| 650 | 7 | |a Fluticasone |2 NLM | |
| 650 | 7 | |a CUT2W21N7U |2 NLM | |
| 650 | 7 | |a Ritonavir |2 NLM | |
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| 700 | 1 | |a Giraud, V |e verfasserin |4 aut | |
| 700 | 1 | |a Leporrier, J |e verfasserin |4 aut | |
| 700 | 1 | |a Greffe, S |e verfasserin |4 aut | |
| 700 | 1 | |a Rouveix, E |e verfasserin |4 aut | |
| 700 | 1 | |a Chinet, T |e verfasserin |4 aut | |
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