CD14(high)CD16(+) rather than CD14(low)CD16(+) monocytes correlate with disease progression in chronic HIV-infected patients
OBJECTIVE: CD14(+)CD16(+) monocytes are an important cellular target for HIV-1 entry and expand in the peripheral blood of HIV-infected individuals. Because CD14(+)CD16(+) monocytes are a heterogeneous population and consist of CD14(high)CD16(+) and CD14(low)CD16(+) subsets, we evaluated the effects of HIV infection on distinct subsets of CD16(+) monocytes.
METHODS: Untreated HIV-infected patients were recruited to investigate the relationship between the proportions of monocyte subsets with plasma viral loads and CD4(+) T-cell counts. Patients receiving highly active antiretroviral therapy (HAART) were followed up in a cross-sectional and a longitudinal study.
RESULTS: Compared with CD14(low)CD16(+), CD14(high)CD16(+) monocytes showed higher levels of CD64 and HLA-DR antigens, which imply that these 2 distinct subsets have different immunoregulatory phenotypes. In HAART-naive patients, elevated proportions of CD14(high)CD16(+) monocytes were correlated with increased viral loads and decreased CD4(+) T-cell counts, whereas CD14(low)CD16(+) monocytes did not show such correlation with disease progression. Of importance, HAART recovered the proportion of CD14(high)CD16(+) monocytes, whereas CD14(low)CD16(+) monocytes did not decrease during 1 year of antiviral therapy.
CONCLUSIONS: Taken together, our observations elucidate distinct immune responses of monocyte subsets during HIV infection and antiviral therapy and provide new insight into the roles of innate immunity in HIV-related pathogenesis.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2009 |
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Erschienen: |
2009 |
Enthalten in: |
Zur Gesamtaufnahme - volume:52 |
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Enthalten in: |
Journal of acquired immune deficiency syndromes (1999) - 52(2009), 5 vom: 26. Dez., Seite 553-9 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Han, Junyan [VerfasserIn] |
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Themen: |
Anti-HIV Agents |
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Anmerkungen: |
Date Completed 21.12.2009 Date Revised 30.09.2020 published: Print Citation Status MEDLINE |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM193173646 |
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100 | 1 | |a Han, Junyan |e verfasserin |4 aut | |
245 | 1 | 0 | |a CD14(high)CD16(+) rather than CD14(low)CD16(+) monocytes correlate with disease progression in chronic HIV-infected patients |
264 | 1 | |c 2009 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 21.12.2009 | ||
500 | |a Date Revised 30.09.2020 | ||
500 | |a published: Print | ||
500 | |a Citation Status MEDLINE | ||
520 | |a OBJECTIVE: CD14(+)CD16(+) monocytes are an important cellular target for HIV-1 entry and expand in the peripheral blood of HIV-infected individuals. Because CD14(+)CD16(+) monocytes are a heterogeneous population and consist of CD14(high)CD16(+) and CD14(low)CD16(+) subsets, we evaluated the effects of HIV infection on distinct subsets of CD16(+) monocytes | ||
520 | |a METHODS: Untreated HIV-infected patients were recruited to investigate the relationship between the proportions of monocyte subsets with plasma viral loads and CD4(+) T-cell counts. Patients receiving highly active antiretroviral therapy (HAART) were followed up in a cross-sectional and a longitudinal study | ||
520 | |a RESULTS: Compared with CD14(low)CD16(+), CD14(high)CD16(+) monocytes showed higher levels of CD64 and HLA-DR antigens, which imply that these 2 distinct subsets have different immunoregulatory phenotypes. In HAART-naive patients, elevated proportions of CD14(high)CD16(+) monocytes were correlated with increased viral loads and decreased CD4(+) T-cell counts, whereas CD14(low)CD16(+) monocytes did not show such correlation with disease progression. Of importance, HAART recovered the proportion of CD14(high)CD16(+) monocytes, whereas CD14(low)CD16(+) monocytes did not decrease during 1 year of antiviral therapy | ||
520 | |a CONCLUSIONS: Taken together, our observations elucidate distinct immune responses of monocyte subsets during HIV infection and antiviral therapy and provide new insight into the roles of innate immunity in HIV-related pathogenesis | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Research Support, Non-U.S. Gov't | |
650 | 7 | |a Anti-HIV Agents |2 NLM | |
650 | 7 | |a HLA-DR Antigens |2 NLM | |
650 | 7 | |a Lipopolysaccharide Receptors |2 NLM | |
650 | 7 | |a Receptors, IgG |2 NLM | |
700 | 1 | |a Wang, Beibei |e verfasserin |4 aut | |
700 | 1 | |a Han, Ning |e verfasserin |4 aut | |
700 | 1 | |a Zhao, Yan |e verfasserin |4 aut | |
700 | 1 | |a Song, Chuan |e verfasserin |4 aut | |
700 | 1 | |a Feng, Xin |e verfasserin |4 aut | |
700 | 1 | |a Mao, Yu |e verfasserin |4 aut | |
700 | 1 | |a Zhang, Fujie |e verfasserin |4 aut | |
700 | 1 | |a Zhao, Hongxin |e verfasserin |4 aut | |
700 | 1 | |a Zeng, Hui |e verfasserin |4 aut | |
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