Bone mineral density in children with steroid-sensitive nephrotic syndrome
OBJECTIVE: To observe the influence of prednisolone treatment on bone mineral density (BMD) in children with idiopathic nephrotic syndrome.
METHODS: Duel-energy X-ray absorptiometry of lumbar spine (L1-L4) was performed on 40 patients (18 first episode and 22 relapsers) of steroid sensitive idiopathic nephrotic syndrome.
RESULTS: Patients of first episode and relapsers had comparable values of mean age, weight, height, body mass index, serum calcium, phosphate, spine area, bone mineral content (BMC) and BMD. Relapsing nephrotic syndrome patients received significantly higher mean total cumulative dose of prednisolone in comparison to first episode (p<0.001). The BMD Z-scores were normal in 39 of 40 (97.5%) patients. On regression analysis, it was found that both BMC and BMD did not correlate with cumulative dose of prednisolone, when other co-variants such as age, weight, height and spine area were adjusted.
CONCLUSION: Bone mineral density in steroid sensitive nephrotic syndrome is unaffected by cumulative dose of prednisolone therapy both in first episode as well as relapser group of patients.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2009 |
|---|---|
| Erschienen: |
2009 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:76 |
|---|---|
| Enthalten in: |
Indian journal of pediatrics - 76(2009), 12 vom: 30. Dez., Seite 1237-9 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Mishra, O P [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
9PHQ9Y1OLM |
|---|
| Anmerkungen: |
Date Completed 21.04.2010 Date Revised 11.03.2022 published: Print Citation Status MEDLINE |
|---|
| doi: |
10.1007/s12098-009-0256-1 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM193044978 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM193044978 | ||
| 003 | DE-627 | ||
| 005 | 20231223194044.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231223s2009 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s12098-009-0256-1 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n0644.xml |
| 035 | |a (DE-627)NLM193044978 | ||
| 035 | |a (NLM)19936659 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Mishra, O P |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Bone mineral density in children with steroid-sensitive nephrotic syndrome |
| 264 | 1 | |c 2009 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 21.04.2010 | ||
| 500 | |a Date Revised 11.03.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVE: To observe the influence of prednisolone treatment on bone mineral density (BMD) in children with idiopathic nephrotic syndrome | ||
| 520 | |a METHODS: Duel-energy X-ray absorptiometry of lumbar spine (L1-L4) was performed on 40 patients (18 first episode and 22 relapsers) of steroid sensitive idiopathic nephrotic syndrome | ||
| 520 | |a RESULTS: Patients of first episode and relapsers had comparable values of mean age, weight, height, body mass index, serum calcium, phosphate, spine area, bone mineral content (BMC) and BMD. Relapsing nephrotic syndrome patients received significantly higher mean total cumulative dose of prednisolone in comparison to first episode (p<0.001). The BMD Z-scores were normal in 39 of 40 (97.5%) patients. On regression analysis, it was found that both BMC and BMD did not correlate with cumulative dose of prednisolone, when other co-variants such as age, weight, height and spine area were adjusted | ||
| 520 | |a CONCLUSION: Bone mineral density in steroid sensitive nephrotic syndrome is unaffected by cumulative dose of prednisolone therapy both in first episode as well as relapser group of patients | ||
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Anti-Inflammatory Agents |2 NLM | |
| 650 | 7 | |a Prednisolone |2 NLM | |
| 650 | 7 | |a 9PHQ9Y1OLM |2 NLM | |
| 700 | 1 | |a Meena, S K |e verfasserin |4 aut | |
| 700 | 1 | |a Singh, S K |e verfasserin |4 aut | |
| 700 | 1 | |a Prasad, R |e verfasserin |4 aut | |
| 700 | 1 | |a Mishra, R N |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Indian journal of pediatrics |d 1945 |g 76(2009), 12 vom: 30. Dez., Seite 1237-9 |w (DE-627)NLM000070742 |x 0973-7693 |7 nnns |
| 773 | 1 | 8 | |g volume:76 |g year:2009 |g number:12 |g day:30 |g month:12 |g pages:1237-9 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1007/s12098-009-0256-1 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 76 |j 2009 |e 12 |b 30 |c 12 |h 1237-9 | ||