A novel composite drug delivery system : honokiol nanoparticles in thermosensitive hydrogel based on chitosan
In this article, a novel composite drug delivery system, honokiol nanoparticles in biodegradable hydrogels based on chitosan (CS) and beta-glycerophosphate (beta-GP), was prepared. CS/beta-GP solution was liquid at room temperature and turned into gel as temperature increased. With increase in beta-GP concentration, the sol-gel transition temperature decreased accordingly. Honokiol nanoparticles with diameter of about 30 nm were prepared by emulsion solvent evaporation method. The sol-gel transition temperature of CS/beta-GP system decreased as F-127 presented in honokiol nanoparticles. In vitro release profiles were studied, the results showed that honokiol could be slowly released from CS/beta-GP gel over at least 2 weeks and the release rate was greatly influenced by initial drug loading. The described injectable hydrogels based on chitosan (CS) and beta-glycerophosphate (beta-GP) might have potential application as local drug delivery for honokiol.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2009 |
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| Erschienen: |
2009 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:9 |
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| Enthalten in: |
Journal of nanoscience and nanotechnology - 9(2009), 8 vom: 01. Aug., Seite 4586-92 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Li, XingYi [VerfasserIn] |
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| Themen: |
11513CCO0N |
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| Anmerkungen: |
Date Completed 24.12.2009 Date Revised 30.03.2022 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM192965638 |
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| 041 | |a eng | ||
| 100 | 1 | |a Li, XingYi |e verfasserin |4 aut | |
| 245 | 1 | 2 | |a A novel composite drug delivery system |b honokiol nanoparticles in thermosensitive hydrogel based on chitosan |
| 264 | 1 | |c 2009 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a Date Completed 24.12.2009 | ||
| 500 | |a Date Revised 30.03.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a In this article, a novel composite drug delivery system, honokiol nanoparticles in biodegradable hydrogels based on chitosan (CS) and beta-glycerophosphate (beta-GP), was prepared. CS/beta-GP solution was liquid at room temperature and turned into gel as temperature increased. With increase in beta-GP concentration, the sol-gel transition temperature decreased accordingly. Honokiol nanoparticles with diameter of about 30 nm were prepared by emulsion solvent evaporation method. The sol-gel transition temperature of CS/beta-GP system decreased as F-127 presented in honokiol nanoparticles. In vitro release profiles were studied, the results showed that honokiol could be slowly released from CS/beta-GP gel over at least 2 weeks and the release rate was greatly influenced by initial drug loading. The described injectable hydrogels based on chitosan (CS) and beta-glycerophosphate (beta-GP) might have potential application as local drug delivery for honokiol | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Biphenyl Compounds |2 NLM | |
| 650 | 7 | |a Hydrogels |2 NLM | |
| 650 | 7 | |a Lignans |2 NLM | |
| 650 | 7 | |a honokiol |2 NLM | |
| 650 | 7 | |a 11513CCO0N |2 NLM | |
| 650 | 7 | |a Chitosan |2 NLM | |
| 650 | 7 | |a 9012-76-4 |2 NLM | |
| 700 | 1 | |a Zheng, XiuLing |e verfasserin |4 aut | |
| 700 | 1 | |a Wei, XiaWei |e verfasserin |4 aut | |
| 700 | 1 | |a Guo, Gang |e verfasserin |4 aut | |
| 700 | 1 | |a Gou, MaLing |e verfasserin |4 aut | |
| 700 | 1 | |a Gong, ChangYang |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, XianHuo |e verfasserin |4 aut | |
| 700 | 1 | |a Dai, Mei |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, LiJuan |e verfasserin |4 aut | |
| 700 | 1 | |a Wei, YuQuan |e verfasserin |4 aut | |
| 700 | 1 | |a Qian, ZhiYong |e verfasserin |4 aut | |
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