A functional genomics approach to tanshinone biosynthesis provides stereochemical insights
Tanshinones are abietane-type norditerpenoid quinone natural products that are the bioactive components of the Chinese medicinal herb Salvia miltiorrhiza Bunge. The initial results from a functional genomics-based investigation of tanshinone biosynthesis, specifically the functional identification of the relevant diterpene synthases from S. miltiorrhiza, are reported. The cyclohexa-1,4-diene arrangement of the distal ring poises the resulting miltiradiene for the ensuing aromatization and hydroxylation to ferruginol suggested for tanshinone biosynthesis.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2009 |
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| Erschienen: |
2009 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:11 |
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| Enthalten in: |
Organic letters - 11(2009), 22 vom: 19. Nov., Seite 5170-3 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Gao, Wei [VerfasserIn] |
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| Links: |
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| Themen: |
03UUH3J385 |
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| Anmerkungen: |
Date Completed 14.01.2010 Date Revised 10.03.2022 published: Print Citation Status MEDLINE |
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| doi: |
10.1021/ol902051v |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM192752774 |
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| 520 | |a Tanshinones are abietane-type norditerpenoid quinone natural products that are the bioactive components of the Chinese medicinal herb Salvia miltiorrhiza Bunge. The initial results from a functional genomics-based investigation of tanshinone biosynthesis, specifically the functional identification of the relevant diterpene synthases from S. miltiorrhiza, are reported. The cyclohexa-1,4-diene arrangement of the distal ring poises the resulting miltiradiene for the ensuing aromatization and hydroxylation to ferruginol suggested for tanshinone biosynthesis | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Huang, Luqi |e verfasserin |4 aut | |
| 700 | 1 | |a Cui, Guanghong |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Xueyong |e verfasserin |4 aut | |
| 700 | 1 | |a Kong, Jianqiang |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Bin |e verfasserin |4 aut | |
| 700 | 1 | |a Peters, Reuben J |e verfasserin |4 aut | |
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