Chaperon-mediated single molecular approach toward modulating Abeta peptide aggregation
We report here a single molecular approach using chaperone-like molecular modulators for modulating the aggregation behavior of a vital analogue of beta-amyloid peptide (Abeta) by using scanning tunneling microscopy. The molecular structures of the beta-sheets for Abeta33-42 peptide are revealed, which are keen to the aggregation of Abeta42 relating to Alzheimer's disease. It was identified that the introduction of chaperone-like modulators could regulate the assembling behavior of the peptide at molecular level. Furthermore, the modulators could also significantly accelerate the aggregation of the peptide in aqueous solution as revealed by light scattering studies. These observations of the molecular modulator effect in peptide assemblies could provide a novel approach toward modulating Abeta peptide aggregations.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2009 |
|---|---|
| Erschienen: |
2009 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:9 |
|---|---|
| Enthalten in: |
Nano letters - 9(2009), 12 vom: 19. Dez., Seite 4066-72 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Liu, Lei [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Amyloid beta-Peptides |
|---|
| Anmerkungen: |
Date Completed 22.02.2010 Date Revised 30.09.2020 published: Print Citation Status MEDLINE |
|---|
| doi: |
10.1021/nl902256b |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM192177486 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM192177486 | ||
| 003 | DE-627 | ||
| 005 | 20231223192511.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231223s2009 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1021/nl902256b |2 doi | |
| 028 | 5 | 2 | |a pubmed24n0641.xml |
| 035 | |a (DE-627)NLM192177486 | ||
| 035 | |a (NLM)19842691 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Liu, Lei |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Chaperon-mediated single molecular approach toward modulating Abeta peptide aggregation |
| 264 | 1 | |c 2009 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 22.02.2010 | ||
| 500 | |a Date Revised 30.09.2020 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a We report here a single molecular approach using chaperone-like molecular modulators for modulating the aggregation behavior of a vital analogue of beta-amyloid peptide (Abeta) by using scanning tunneling microscopy. The molecular structures of the beta-sheets for Abeta33-42 peptide are revealed, which are keen to the aggregation of Abeta42 relating to Alzheimer's disease. It was identified that the introduction of chaperone-like modulators could regulate the assembling behavior of the peptide at molecular level. Furthermore, the modulators could also significantly accelerate the aggregation of the peptide in aqueous solution as revealed by light scattering studies. These observations of the molecular modulator effect in peptide assemblies could provide a novel approach toward modulating Abeta peptide aggregations | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Amyloid beta-Peptides |2 NLM | |
| 650 | 7 | |a Molecular Chaperones |2 NLM | |
| 650 | 7 | |a Multiprotein Complexes |2 NLM | |
| 700 | 1 | |a Zhang, Lan |e verfasserin |4 aut | |
| 700 | 1 | |a Mao, Xiaobo |e verfasserin |4 aut | |
| 700 | 1 | |a Niu, Lin |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Yanlian |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Chen |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Nano letters |d 2001 |g 9(2009), 12 vom: 19. Dez., Seite 4066-72 |w (DE-627)NLM154096849 |x 1530-6992 |7 nnns |
| 773 | 1 | 8 | |g volume:9 |g year:2009 |g number:12 |g day:19 |g month:12 |g pages:4066-72 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1021/nl902256b |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 9 |j 2009 |e 12 |b 19 |c 12 |h 4066-72 | ||