Ambulatory ECG-based T-wave alternans and heart rate turbulence predict high risk of arrhythmic events in patients with old myocardial infarction
BACKGROUND: Few studies have explored risk stratification of arrhythmic events in patients with ischemic heart diseases according to T-wave alternans (TWA) using modified moving average (MMA) method and heart rate turbulence (HRT).
METHODS AND RESULTS: A retrospective analysis of 63 patients who underwent MMA-based TWA and HRT divided the patients into 3 groups: group-C of 21 controls, group-O of 21 patients with old myocardial infarction (OMI) showing no episodes of sustained ventricular tachyarrhythmia (SVT), and group-V of 21 OMI patients with episodes of SVT who received an implantable cardioverter-defibrillator. Among the 3 groups, positive TWA (>or=65 microV) and impaired HRT were observed most frequently in group-V (P<0.05). Using a logistic regression model, TWA yielded an odds ratio of 4.9 (95% confidence interval: 1.2-19.6, P<0.05), which was the only significant covariate for the incidence of life-threatening ventricular arrhythmias during a mean follow-up of 72 months.
CONCLUSIONS: Patients with OMI showing episodes of SVT have a high risk for cardiac death because of abnormal repolarization and autonomic regulation. The analysis of MMA-based TWA and HRT can be a useful tool for predicting OMI patients at high risk of arrhythmic events.
| Errataetall: |
CommentIn: Circ J. 2010 Mar;74(3):594; author reply 595. - PMID 20081318 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2009 |
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| Erschienen: |
2009 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:73 |
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| Enthalten in: |
Circulation journal : official journal of the Japanese Circulation Society - 73(2009), 12 vom: Dez., Seite 2223-8 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Maeda, Shingo [VerfasserIn] |
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| Themen: |
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| Anmerkungen: |
Date Completed 28.01.2010 Date Revised 19.08.2019 published: Print-Electronic CommentIn: Circ J. 2010 Mar;74(3):594; author reply 595. - PMID 20081318 Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM19213258X |
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| 100 | 1 | |a Maeda, Shingo |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Ambulatory ECG-based T-wave alternans and heart rate turbulence predict high risk of arrhythmic events in patients with old myocardial infarction |
| 264 | 1 | |c 2009 | |
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| 500 | |a Date Completed 28.01.2010 | ||
| 500 | |a Date Revised 19.08.2019 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a CommentIn: Circ J. 2010 Mar;74(3):594; author reply 595. - PMID 20081318 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: Few studies have explored risk stratification of arrhythmic events in patients with ischemic heart diseases according to T-wave alternans (TWA) using modified moving average (MMA) method and heart rate turbulence (HRT) | ||
| 520 | |a METHODS AND RESULTS: A retrospective analysis of 63 patients who underwent MMA-based TWA and HRT divided the patients into 3 groups: group-C of 21 controls, group-O of 21 patients with old myocardial infarction (OMI) showing no episodes of sustained ventricular tachyarrhythmia (SVT), and group-V of 21 OMI patients with episodes of SVT who received an implantable cardioverter-defibrillator. Among the 3 groups, positive TWA (>or=65 microV) and impaired HRT were observed most frequently in group-V (P<0.05). Using a logistic regression model, TWA yielded an odds ratio of 4.9 (95% confidence interval: 1.2-19.6, P<0.05), which was the only significant covariate for the incidence of life-threatening ventricular arrhythmias during a mean follow-up of 72 months | ||
| 520 | |a CONCLUSIONS: Patients with OMI showing episodes of SVT have a high risk for cardiac death because of abnormal repolarization and autonomic regulation. The analysis of MMA-based TWA and HRT can be a useful tool for predicting OMI patients at high risk of arrhythmic events | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Nishizaki, Mitsuhiro |e verfasserin |4 aut | |
| 700 | 1 | |a Yamawake, Noriyoshi |e verfasserin |4 aut | |
| 700 | 1 | |a Ashikaga, Takashi |e verfasserin |4 aut | |
| 700 | 1 | |a Shimada, Hiroshi |e verfasserin |4 aut | |
| 700 | 1 | |a Asano, Mitsutoshi |e verfasserin |4 aut | |
| 700 | 1 | |a Ihara, Kensuke |e verfasserin |4 aut | |
| 700 | 1 | |a Murai, Tadashi |e verfasserin |4 aut | |
| 700 | 1 | |a Suzuki, Hidetoshi |e verfasserin |4 aut | |
| 700 | 1 | |a Fujii, Hiroyuki |e verfasserin |4 aut | |
| 700 | 1 | |a Sakurada, Harumizu |e verfasserin |4 aut | |
| 700 | 1 | |a Hiraoka, Masayasu |e verfasserin |4 aut | |
| 700 | 1 | |a Isobe, Mitsuaki |e verfasserin |4 aut | |
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