PTPsigma is a receptor for chondroitin sulfate proteoglycan, an inhibitor of neural regeneration
Chondroitin sulfate proteoglycans (CSPGs) present a barrier to axon regeneration. However, no specific receptor for the inhibitory effect of CSPGs has been identified. We showed that a transmembrane protein tyrosine phosphatase, PTPsigma, binds with high affinity to neural CSPGs. Binding involves the chondroitin sulfate chains and a specific site on the first immunoglobulin-like domain of PTPsigma. In culture, PTPsigma(-/-) neurons show reduced inhibition by CSPG. A PTPsigma fusion protein probe can detect cognate ligands that are up-regulated specifically at neural lesion sites. After spinal cord injury, PTPsigma gene disruption enhanced the ability of axons to penetrate regions containing CSPG. These results indicate that PTPsigma can act as a receptor for CSPGs and may provide new therapeutic approaches to neural regeneration.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2009 |
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| Erschienen: |
2009 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:326 |
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| Enthalten in: |
Science (New York, N.Y.) - 326(2009), 5952 vom: 23. Okt., Seite 592-6 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Shen, Yingjie [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 01.12.2009 Date Revised 11.05.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1126/science.1178310 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM192093347 |
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| 520 | |a Chondroitin sulfate proteoglycans (CSPGs) present a barrier to axon regeneration. However, no specific receptor for the inhibitory effect of CSPGs has been identified. We showed that a transmembrane protein tyrosine phosphatase, PTPsigma, binds with high affinity to neural CSPGs. Binding involves the chondroitin sulfate chains and a specific site on the first immunoglobulin-like domain of PTPsigma. In culture, PTPsigma(-/-) neurons show reduced inhibition by CSPG. A PTPsigma fusion protein probe can detect cognate ligands that are up-regulated specifically at neural lesion sites. After spinal cord injury, PTPsigma gene disruption enhanced the ability of axons to penetrate regions containing CSPG. These results indicate that PTPsigma can act as a receptor for CSPGs and may provide new therapeutic approaches to neural regeneration | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 7 | |a Nerve Tissue Proteins |2 NLM | |
| 650 | 7 | |a Neurocan |2 NLM | |
| 650 | 7 | |a Proteoglycans |2 NLM | |
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| 700 | 1 | |a Tenney, Alan P |e verfasserin |4 aut | |
| 700 | 1 | |a Busch, Sarah A |e verfasserin |4 aut | |
| 700 | 1 | |a Horn, Kevin P |e verfasserin |4 aut | |
| 700 | 1 | |a Cuascut, Fernando X |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Kai |e verfasserin |4 aut | |
| 700 | 1 | |a He, Zhigang |e verfasserin |4 aut | |
| 700 | 1 | |a Silver, Jerry |e verfasserin |4 aut | |
| 700 | 1 | |a Flanagan, John G |e verfasserin |4 aut | |
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