Prognostic prediction in patients with hepatocellular carcinoma not amenable to locoregional treatment
BACKGROUND AND OBJECTIVE: Patients with hepatocellular carcinoma (HCC) not amenable to locoregional therapy have some specific clinical characteristics (advanced cirrhosis or extrahepatic spread) that lead us to ascertain the prognostic efficacy of the different staging systems proposed for this entity.
PATIENTS AND METHOD: We analyze 100 patients (69 males) with a mean age of 70.2 (10.7) years. Tumor staging was performed at baseline according to the following systems: Okuda, Cancer of the Liver Italian Program (CLIP), Barcelona Clinic Liver Cancer (BCLC), and Japan Integrated Staging (JIS) score. We determine the area under the receiver operating characteristic curve (AUC) using the 6 and 12-month mortality as endpoint.
RESULTS: The BCLC system had the best predictive power for mortality both at 6 (AUC, 0.871) and 12 months (AUC, 0.924) from diagnosis. In the Cox multivariate analysis, this model showed an independent prognostic effect [hazard ratio: 9.14 for BCLC stage C versus A (p<0.001), and 9.53 for stage D versus A (p=0.004)].
CONCLUSIONS: The BCLC system provided the best prognostic stratification for patients with HCC not amenable to locoregional therapy.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2009 |
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| Erschienen: |
2009 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:133 |
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| Enthalten in: |
Medicina clinica - 133(2009), 15 vom: 24. Okt., Seite 581-5 |
| Sprache: |
Spanisch |
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| Weiterer Titel: |
Predicción pronóstica en pacientes con carcinoma hepatocelular no subsidiario de tratamiento locorregional |
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| Beteiligte Personen: |
Fernández-Ruiz, Mario [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 03.02.2010 Date Revised 20.10.2009 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.medcli.2009.06.053 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM191300845 |
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| 245 | 1 | 0 | |a Prognostic prediction in patients with hepatocellular carcinoma not amenable to locoregional treatment |
| 246 | 3 | 3 | |a Predicción pronóstica en pacientes con carcinoma hepatocelular no subsidiario de tratamiento locorregional |
| 264 | 1 | |c 2009 | |
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| 500 | |a Date Completed 03.02.2010 | ||
| 500 | |a Date Revised 20.10.2009 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND AND OBJECTIVE: Patients with hepatocellular carcinoma (HCC) not amenable to locoregional therapy have some specific clinical characteristics (advanced cirrhosis or extrahepatic spread) that lead us to ascertain the prognostic efficacy of the different staging systems proposed for this entity | ||
| 520 | |a PATIENTS AND METHOD: We analyze 100 patients (69 males) with a mean age of 70.2 (10.7) years. Tumor staging was performed at baseline according to the following systems: Okuda, Cancer of the Liver Italian Program (CLIP), Barcelona Clinic Liver Cancer (BCLC), and Japan Integrated Staging (JIS) score. We determine the area under the receiver operating characteristic curve (AUC) using the 6 and 12-month mortality as endpoint | ||
| 520 | |a RESULTS: The BCLC system had the best predictive power for mortality both at 6 (AUC, 0.871) and 12 months (AUC, 0.924) from diagnosis. In the Cox multivariate analysis, this model showed an independent prognostic effect [hazard ratio: 9.14 for BCLC stage C versus A (p<0.001), and 9.53 for stage D versus A (p=0.004)] | ||
| 520 | |a CONCLUSIONS: The BCLC system provided the best prognostic stratification for patients with HCC not amenable to locoregional therapy | ||
| 650 | 4 | |a English Abstract | |
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Guerra-Vales, Juan Manuel |e verfasserin |4 aut | |
| 700 | 1 | |a Vila-Santos, Juan |e verfasserin |4 aut | |
| 700 | 1 | |a Colina-Ruizdelgado, Francisco |e verfasserin |4 aut | |
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