Seroprevalence of HTLV-1/2 infection among native and immigrant pregnant women in Spain
HTLV-1=2 antenatal screening is not mandatory in European countries. The rapid increase in immigrants coming from areas endemic for HTLV-1 infection has compelled a review of this policy in Spain. From February 2006 to December 2007, a cross-sectional study was carried out in all pregnant women attended at 10 different Spanish hospitals. An enzyme immunoassay (EIA) was used to test serum HTLV-1=2 antibodies; reactive samples were further confirmed by Western blot and=or polymerase chain reaction. A total of 20,518 pregnant women were examined, of whom 18,266 (89%) were native Spaniards. Overall, 946 (4.6%) of the immigrants came from HTLV-1 endemic areas (mainly Central and South America and sub-Saharan Africa). Four samples were EIA seroreactive for HTLV-1=2, two of them in women infected with HTLV-1 coming from endemic areas. The other two women were infected with HTLV-2; one was an immigrant from Bolivia and another was a native Spaniard who admitted prior injection drug use and was HIV-1 positive. The overall HTLV-1=2 seroprevalence was 0.19 per 1000 (95% CI: 0.05-0.49=1000). For HTLV-1, the seroprevalence was 2.11 per 1000 (95% CI: 0.26-7.62=1000) in pregnant women from endemic areas. The seroprevalence of HTLV-1=2 infection is below 0.02% among pregnant women in Spain, and therefore universal screening for HTLV-1=2 infection in antenatal clinics is not warranted. However, HTLV-1=2 screening could be considered in pregnant women coming from endemic areas, in whom the rate of infection is nearly 1000-fold higher than in native Spaniards and are the only group infected with the more pathogenic HTLV-1.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2009 |
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Erschienen: |
2009 |
Enthalten in: |
Zur Gesamtaufnahme - volume:25 |
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Enthalten in: |
AIDS research and human retroviruses - 25(2009), 6 vom: 18. Juni, Seite 551-4 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Treviño, Ana [VerfasserIn] |
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Themen: |
Antibodies, Viral |
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Anmerkungen: |
Date Completed 28.07.2009 Date Revised 11.11.2019 published: Print Citation Status MEDLINE |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM189456477 |
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520 | |a HTLV-1=2 antenatal screening is not mandatory in European countries. The rapid increase in immigrants coming from areas endemic for HTLV-1 infection has compelled a review of this policy in Spain. From February 2006 to December 2007, a cross-sectional study was carried out in all pregnant women attended at 10 different Spanish hospitals. An enzyme immunoassay (EIA) was used to test serum HTLV-1=2 antibodies; reactive samples were further confirmed by Western blot and=or polymerase chain reaction. A total of 20,518 pregnant women were examined, of whom 18,266 (89%) were native Spaniards. Overall, 946 (4.6%) of the immigrants came from HTLV-1 endemic areas (mainly Central and South America and sub-Saharan Africa). Four samples were EIA seroreactive for HTLV-1=2, two of them in women infected with HTLV-1 coming from endemic areas. The other two women were infected with HTLV-2; one was an immigrant from Bolivia and another was a native Spaniard who admitted prior injection drug use and was HIV-1 positive. The overall HTLV-1=2 seroprevalence was 0.19 per 1000 (95% CI: 0.05-0.49=1000). For HTLV-1, the seroprevalence was 2.11 per 1000 (95% CI: 0.26-7.62=1000) in pregnant women from endemic areas. The seroprevalence of HTLV-1=2 infection is below 0.02% among pregnant women in Spain, and therefore universal screening for HTLV-1=2 infection in antenatal clinics is not warranted. However, HTLV-1=2 screening could be considered in pregnant women coming from endemic areas, in whom the rate of infection is nearly 1000-fold higher than in native Spaniards and are the only group infected with the more pathogenic HTLV-1 | ||
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700 | 1 | |a Caballero, Estrella |e verfasserin |4 aut | |
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700 | 1 | |a Eiros, José M |e verfasserin |4 aut | |
700 | 1 | |a Ortiz de Lejarazu, Raúl |e verfasserin |4 aut | |
700 | 1 | |a Rodríguez-Calviño, Juan J |e verfasserin |4 aut | |
700 | 1 | |a Tuset, Concepción |e verfasserin |4 aut | |
700 | 1 | |a Gómez-Hernando, César |e verfasserin |4 aut | |
700 | 1 | |a Rodríguez-Iglesias, Manuel |e verfasserin |4 aut | |
700 | 1 | |a Ramos, José Manuel |e verfasserin |4 aut | |
700 | 1 | |a Rodríguez-Díaz, Juan C |e verfasserin |4 aut | |
700 | 1 | |a Benito, Rafael |e verfasserin |4 aut | |
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700 | 1 | |a Calderón, Enrique |e verfasserin |4 aut | |
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700 | 1 | |a Rodríguez, Carmen |e verfasserin |4 aut | |
700 | 1 | |a Soriano, Vincent |e verfasserin |4 aut | |
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