Modeling CD4+ cell count increase over a six-year period in HIV-1-infected patients on highly active antiretroviral therapy in Senegal
To assess the extents and determinants of long-term CD4 cell increases after initiation of antiretroviral therapy (ART), changes in CD4 cell counts were analyzed in a cohort of HIV-1-infected Senegalese using a mixed-effects model. After a median follow-up of 54 months, an average of 483 CD4 cells/mm3 (95% confidence interval [CI] = 331; 680) was reached. The average asymptote level was approximately 421 cells/mm3 (95% CI = 390; 454) in patients with < 200 cells/mm3 at baseline and approximately 500 cells/mm3 in patients with > 200 cells/mm3. The independent predictors of long-term CD4 cell reconstitution were the baseline CD4 cell count and the monthly average viral load over the entire follow-up. This good long-term immune reconstitution, optimal in subjects with low average viral loads and > 200 CD4 cells/mm3 at baseline, argues in favor of the earliest possible access to ART and underlines the importance of strict compliance with the treatment.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2009 |
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| Erschienen: |
2009 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:80 |
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| Enthalten in: |
The American journal of tropical medicine and hygiene - 80(2009), 6 vom: 15. Juni, Seite 1047-53 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
De Beaudrap, Pierre [VerfasserIn] |
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| Themen: |
Anti-HIV Agents |
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| Anmerkungen: |
Date Completed 25.06.2009 Date Revised 29.05.2009 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM188866329 |
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| 100 | 1 | |a De Beaudrap, Pierre |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Modeling CD4+ cell count increase over a six-year period in HIV-1-infected patients on highly active antiretroviral therapy in Senegal |
| 264 | 1 | |c 2009 | |
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| 500 | |a Date Completed 25.06.2009 | ||
| 500 | |a Date Revised 29.05.2009 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a To assess the extents and determinants of long-term CD4 cell increases after initiation of antiretroviral therapy (ART), changes in CD4 cell counts were analyzed in a cohort of HIV-1-infected Senegalese using a mixed-effects model. After a median follow-up of 54 months, an average of 483 CD4 cells/mm3 (95% confidence interval [CI] = 331; 680) was reached. The average asymptote level was approximately 421 cells/mm3 (95% CI = 390; 454) in patients with < 200 cells/mm3 at baseline and approximately 500 cells/mm3 in patients with > 200 cells/mm3. The independent predictors of long-term CD4 cell reconstitution were the baseline CD4 cell count and the monthly average viral load over the entire follow-up. This good long-term immune reconstitution, optimal in subjects with low average viral loads and > 200 CD4 cells/mm3 at baseline, argues in favor of the earliest possible access to ART and underlines the importance of strict compliance with the treatment | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Anti-HIV Agents |2 NLM | |
| 700 | 1 | |a Etard, Jean-François |e verfasserin |4 aut | |
| 700 | 1 | |a Diouf, Assane |e verfasserin |4 aut | |
| 700 | 1 | |a Ndiaye, Ibrahima |e verfasserin |4 aut | |
| 700 | 1 | |a Guèye, Ndèye Fatou |e verfasserin |4 aut | |
| 700 | 1 | |a Guèye, Pape Mandoumbé |e verfasserin |4 aut | |
| 700 | 1 | |a Sow, Papa Salif |e verfasserin |4 aut | |
| 700 | 1 | |a Mboup, Souleymane |e verfasserin |4 aut | |
| 700 | 1 | |a Ndoye, Ibra |e verfasserin |4 aut | |
| 700 | 1 | |a Ecochard, René |e verfasserin |4 aut | |
| 700 | 1 | |a Eric, Delaporte |e verfasserin |4 aut | |
| 700 | 0 | |a ANRS 1215/90 Study Group |e verfasserin |4 aut | |
| 700 | 1 | |a Ndoye, I |e investigator |4 oth | |
| 700 | 1 | |a Delaporte, E |e investigator |4 oth | |
| 700 | 1 | |a Etard, J F |e investigator |4 oth | |
| 700 | 1 | |a Laurent, C |e investigator |4 oth | |
| 700 | 1 | |a Taverne, B |e investigator |4 oth | |
| 700 | 1 | |a Thierry-Mieg, M |e investigator |4 oth | |
| 700 | 1 | |a Bitèye, M M |e investigator |4 oth | |
| 700 | 1 | |a Dieng, A B |e investigator |4 oth | |
| 700 | 1 | |a Diouf, A |e investigator |4 oth | |
| 700 | 1 | |a Sarr, A |e investigator |4 oth | |
| 700 | 1 | |a Zié, L |e investigator |4 oth | |
| 700 | 1 | |a Cilote, V |e investigator |4 oth | |
| 700 | 1 | |a Lanièce, I |e investigator |4 oth | |
| 700 | 1 | |a Ndiaye, I |e investigator |4 oth | |
| 700 | 1 | |a Ndir, A |e investigator |4 oth | |
| 700 | 1 | |a Ndour, C T |e investigator |4 oth | |
| 700 | 1 | |a Senghor, C S |e investigator |4 oth | |
| 700 | 1 | |a Sow, P S |e investigator |4 oth | |
| 700 | 1 | |a Basty Fall, M |e investigator |4 oth | |
| 700 | 1 | |a Dia Badiane, N M |e investigator |4 oth | |
| 700 | 1 | |a Diakhaté, N |e investigator |4 oth | |
| 700 | 1 | |a Diallo, M |e investigator |4 oth | |
| 700 | 1 | |a Diouf, L M |e investigator |4 oth | |
| 700 | 1 | |a Ngom Guèye, N F |e investigator |4 oth | |
| 700 | 1 | |a Ba Fall, K |e investigator |4 oth | |
| 700 | 1 | |a Guèye, P M |e investigator |4 oth | |
| 700 | 1 | |a Périno, C |e investigator |4 oth | |
| 700 | 1 | |a Diaw, P A |e investigator |4 oth | |
| 700 | 1 | |a Diop Ndiaye, H |e investigator |4 oth | |
| 700 | 1 | |a Mboup, S |e investigator |4 oth | |
| 700 | 1 | |a Touré Kane, N C |e investigator |4 oth | |
| 700 | 1 | |a Sow, K |e investigator |4 oth | |
| 700 | 1 | |a Diop, K |e investigator |4 oth | |
| 700 | 1 | |a Ndiaye, B |e investigator |4 oth | |
| 700 | 1 | |a Ciss, M |e investigator |4 oth | |
| 700 | 1 | |a Desclaux, A |e investigator |4 oth | |
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