Design, synthesis and insulin-sensitizing activity of indomethacin and diclofenac derivatives
A series of aromatic acetic acid compounds were designed and synthesized on the basis of Non-steroidal anti-inflammatory drugs indomethacin and diclofenac. Compounds 5a, 7a, 5h, 7h and 17 could strongly promote insulin-regulated differentiation of 3T3-L1 cells in vitro. They acted as full or partial PPARgamma agonist, or improved insulin resistance through non-PPARgamma pathway.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2009 |
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| Erschienen: |
2009 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:19 |
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| Enthalten in: |
Bioorganic & medicinal chemistry letters - 19(2009), 12 vom: 15. Juni, Seite 3324-7 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zhang, Jiquan [VerfasserIn] |
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| Links: |
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| Themen: |
144O8QL0L1 |
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| Anmerkungen: |
Date Completed 21.08.2009 Date Revised 21.11.2013 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.bmcl.2009.04.050 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM188348433 |
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| 245 | 1 | 0 | |a Design, synthesis and insulin-sensitizing activity of indomethacin and diclofenac derivatives |
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| 520 | |a A series of aromatic acetic acid compounds were designed and synthesized on the basis of Non-steroidal anti-inflammatory drugs indomethacin and diclofenac. Compounds 5a, 7a, 5h, 7h and 17 could strongly promote insulin-regulated differentiation of 3T3-L1 cells in vitro. They acted as full or partial PPARgamma agonist, or improved insulin resistance through non-PPARgamma pathway | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Anti-Inflammatory Agents, Non-Steroidal |2 NLM | |
| 650 | 7 | |a Cyclooxygenase Inhibitors |2 NLM | |
| 650 | 7 | |a Insulin |2 NLM | |
| 650 | 7 | |a PPAR gamma |2 NLM | |
| 650 | 7 | |a Diclofenac |2 NLM | |
| 650 | 7 | |a 144O8QL0L1 |2 NLM | |
| 650 | 7 | |a Indomethacin |2 NLM | |
| 650 | 7 | |a XXE1CET956 |2 NLM | |
| 700 | 1 | |a Wang, Jianta |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Haoshu |e verfasserin |4 aut | |
| 700 | 1 | |a He, Yaoyao |e verfasserin |4 aut | |
| 700 | 1 | |a Zhu, Gaofeng |e verfasserin |4 aut | |
| 700 | 1 | |a Cui, Xing |e verfasserin |4 aut | |
| 700 | 1 | |a Tang, Lei |e verfasserin |4 aut | |
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