Cardiovascular complications at 1-year of follow-up in patients with atherothrombosis. On behalf of Spain's REACH Registry
BACKGROUND AND OBJECTIVE: The REACH Registry is the largest worldwide designed to obtain information on cardiovascular risk factor control and preventive treatment in a population who have, or are at risk of having, symptoms of atherothrombosis. The objective of this study is to show the results of cardiovascular events obtained in a sample of the Spanish population at one year follow-up and intervention.
MATERIAL AND METHOD: The REACH Spain registry is a prospective cohort study of subjects with vascular risk factors (ORF) for atherothrombosis or with symptomatic vascular disease (VD): coronary artery disease (CAD) and/or cerebrovascular disease (CVD) and/or peripheral artery disease (PAD). The main outcome measures were rates of all-cause mortality, cardiovascular (CV) death, and the overall combined CV death, myocardial infarction (MI), or stroke and CV hospitalization at one year follow-up.
RESULTS: In Spain 2,516 patients were recruited and 2,252 completed one year follow-up, the mean age was 68,1 (73,8% men), 11,6% of subjects with ORF and 88,5% with VD, 55% with CAD, 33% with CVD and 17% with PAD. The annual rate of all-cause mortality in VD and ORF groups were 3,57% and 1,98% (NS) respectively, while for CV death they were 2,69% and 0,62% (P<.05) and for overall combined CV death myocardial infarction (MI), or stroke and CV hospitalization they were 15,34% and 5,47% (P=.0001). The annual rate of CV death for CAD, CVD and PAD groups were 3,47%, 2,78% and 1,46% respectively, and for the overall combined CV death, myocardial infarction (MI) , or stroke and CV hospitalization they were 18,52%, 13,75% and 14,52%. These event rates increased with the number of symptomatic arterial disease locations from 0,1,2 or 3 for CV death (0,62%, 2,46%, 3,55% and 4,32%, respectively P<.05) and for overall combined CV death myocardial infarction (MI), or stroke and CV hospitalization (5,50%, 4,18%, 20,59% y 19,40%, respectively P<.0001). At one year follow-up, 82,8% of the patients were with at least one antiplatelet drug and 86,2% were receiving lipid-lowering agents.
CONCLUSIONS: The REACH Spain Registry at one year follow-up in patients with atherothrombotic disease or at risk of having symptoms of atherothrombosis shows a high rate of all-cause mortality and of overall combined major CV events, which is becoming higher as the number of symptomatic arterial disease locations increases.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2009 |
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| Erschienen: |
2009 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:132 |
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| Enthalten in: |
Medicina clinica - 132(2009), 14 vom: 18. Apr., Seite 537-44 |
| Sprache: |
Spanisch |
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| Weiterer Titel: |
Complicaciones cardiovasculares a un año de seguimiento en pacientes con aterotrombosis. Registro REACH España |
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| Links: |
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| Themen: |
English Abstract |
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| Anmerkungen: |
Date Completed 20.08.2009 Date Revised 27.04.2009 published: Print Citation Status MEDLINE |
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| doi: |
10.1016/j.medcli.2008.11.033 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM188069941 |
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| 245 | 1 | 0 | |a Cardiovascular complications at 1-year of follow-up in patients with atherothrombosis. On behalf of Spain's REACH Registry |
| 246 | 3 | 3 | |a Complicaciones cardiovasculares a un año de seguimiento en pacientes con aterotrombosis. Registro REACH España |
| 264 | 1 | |c 2009 | |
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| 500 | |a Date Completed 20.08.2009 | ||
| 500 | |a Date Revised 27.04.2009 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND AND OBJECTIVE: The REACH Registry is the largest worldwide designed to obtain information on cardiovascular risk factor control and preventive treatment in a population who have, or are at risk of having, symptoms of atherothrombosis. The objective of this study is to show the results of cardiovascular events obtained in a sample of the Spanish population at one year follow-up and intervention | ||
| 520 | |a MATERIAL AND METHOD: The REACH Spain registry is a prospective cohort study of subjects with vascular risk factors (ORF) for atherothrombosis or with symptomatic vascular disease (VD): coronary artery disease (CAD) and/or cerebrovascular disease (CVD) and/or peripheral artery disease (PAD). The main outcome measures were rates of all-cause mortality, cardiovascular (CV) death, and the overall combined CV death, myocardial infarction (MI), or stroke and CV hospitalization at one year follow-up | ||
| 520 | |a RESULTS: In Spain 2,516 patients were recruited and 2,252 completed one year follow-up, the mean age was 68,1 (73,8% men), 11,6% of subjects with ORF and 88,5% with VD, 55% with CAD, 33% with CVD and 17% with PAD. The annual rate of all-cause mortality in VD and ORF groups were 3,57% and 1,98% (NS) respectively, while for CV death they were 2,69% and 0,62% (P<.05) and for overall combined CV death myocardial infarction (MI), or stroke and CV hospitalization they were 15,34% and 5,47% (P=.0001). The annual rate of CV death for CAD, CVD and PAD groups were 3,47%, 2,78% and 1,46% respectively, and for the overall combined CV death, myocardial infarction (MI) , or stroke and CV hospitalization they were 18,52%, 13,75% and 14,52%. These event rates increased with the number of symptomatic arterial disease locations from 0,1,2 or 3 for CV death (0,62%, 2,46%, 3,55% and 4,32%, respectively P<.05) and for overall combined CV death myocardial infarction (MI), or stroke and CV hospitalization (5,50%, 4,18%, 20,59% y 19,40%, respectively P<.0001). At one year follow-up, 82,8% of the patients were with at least one antiplatelet drug and 86,2% were receiving lipid-lowering agents | ||
| 520 | |a CONCLUSIONS: The REACH Spain Registry at one year follow-up in patients with atherothrombotic disease or at risk of having symptoms of atherothrombosis shows a high rate of all-cause mortality and of overall combined major CV events, which is becoming higher as the number of symptomatic arterial disease locations increases | ||
| 650 | 4 | |a English Abstract | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 700 | 1 | |a Castillo, José |e verfasserin |4 aut | |
| 700 | 1 | |a Esmatjes, Enric |e verfasserin |4 aut | |
| 700 | 1 | |a Sala, Joan |e verfasserin |4 aut | |
| 700 | 1 | |a Cairols, Marc |e verfasserin |4 aut | |
| 700 | 1 | |a Montoto, Carmen |e verfasserin |4 aut | |
| 700 | 1 | |a Barberá, Gloria |e verfasserin |4 aut | |
| 700 | 0 | |a en representación de los investigadores del registro REACH España |e verfasserin |4 aut | |
| 700 | 1 | |a Abeytua Jimenez, Manuel |e investigator |4 oth | |
| 700 | 1 | |a Dolores Adarriaga, M |e investigator |4 oth | |
| 700 | 1 | |a Agarrado Luna, Antonio |e investigator |4 oth | |
| 700 | 1 | |a Jesus Alias Linares, Eduardo |e investigator |4 oth | |
| 700 | 1 | |a Almagro Mugica, Fatima |e investigator |4 oth | |
| 700 | 1 | |a Alonso Garcia, Guillermo |e investigator |4 oth | |
| 700 | 1 | |a Alonso Martin, Joaquin |e investigator |4 oth | |
| 700 | 1 | |a Alonso Martinez, Jose Luis |e investigator |4 oth | |
| 700 | 1 | |a Alvarenga Recalde, Nelson Maria |e investigator |4 oth | |
| 700 | 1 | |a Alvarez Aunon, Amparo |e investigator |4 oth | |
| 700 | 1 | |a Alvarez Fernandez, Javier |e investigator |4 oth | |
| 700 | 1 | |a Andres Novales, Javier |e investigator |4 oth | |
| 700 | 1 | |a Andreu Alvarez, Juan |e investigator |4 oth | |
| 700 | 1 | |a Anton Serra, Jose A |e investigator |4 oth | |
| 700 | 1 | |a Arias Castano, Juan Carlos |e investigator |4 oth | |
| 700 | 1 | |a Sanchez de Rojas, Ignacio Artigues |e investigator |4 oth | |
| 700 | 1 | |a Baldo Perez, Emilio C |e investigator |4 oth | |
| 700 | 1 | |a Barrios, Antonio |e investigator |4 oth | |
| 700 | 1 | |a Bautista Prados, Joaquin G |e investigator |4 oth | |
| 700 | 1 | |a Bellera Gotarda, M Nieves |e investigator |4 oth | |
| 700 | 1 | |a Bello Lopez, Joan |e investigator |4 oth | |
| 700 | 1 | |a Beloqui Ruiz, Oscar |e investigator |4 oth | |
| 700 | 1 | |a Bermudez Garcia, Jose Maria |e investigator |4 oth | |
| 700 | 1 | |a Blanco Gonzalez, Miguel |e investigator |4 oth | |
| 700 | 1 | |a Blasco, Ana |e investigator |4 oth | |
| 700 | 1 | |a Bohorquez Sierra, Juan Carlos |e investigator |4 oth | |
| 700 | 1 | |a Bolanos Diaz, Alfonso |e investigator |4 oth | |
| 700 | 1 | |a Brossa Loidi, Vicent |e investigator |4 oth | |
| 700 | 1 | |a Bruguera Cortada, Jorge |e investigator |4 oth | |
| 700 | 1 | |a Cabarcos Cazon, Antonio |e investigator |4 oth | |
| 700 | 1 | |a Cacabelos Perez, Purificación |e investigator |4 oth | |
| 700 | 1 | |a Cairols Castellote, Marc |e investigator |4 oth | |
| 700 | 1 | |a Calvo Gómez, Carlos |e investigator |4 oth | |
| 700 | 1 | |a Camacho Azcargota, Ignacio |e investigator |4 oth | |
| 700 | 1 | |a Caminero Rodriguez, Ana Belén |e investigator |4 oth | |
| 700 | 1 | |a Canoves Femenia, Joaquín |e investigator |4 oth | |
| 700 | 1 | |a Carbonell Coll, Pere |e investigator |4 oth | |
| 700 | 1 | |a Carmona Alvarez, José A |e investigator |4 oth | |
| 700 | 1 | |a Cruz Carreño, María |e investigator |4 oth | |
| 700 | 1 | |a Casado Menéndez, Ignacio |e investigator |4 oth | |
| 700 | 1 | |a Casado Naranjo, Ignacio |e investigator |4 oth | |
| 700 | 1 | |a Castillo, Jose |e investigator |4 oth | |
| 700 | 1 | |a Catalán Ramos, José Ignacio |e investigator |4 oth | |
| 700 | 1 | |a Catalán Sanz, Paz |e investigator |4 oth | |
| 700 | 1 | |a Caudevilla Martinez, Aranzazu |e investigator |4 oth | |
| 700 | 1 | |a Cerda Fayos, José |e investigator |4 oth | |
| 700 | 1 | |a Chamarro Lázaro, Pilar Raquel |e investigator |4 oth | |
| 700 | 1 | |a Charles Chevannes, Alfredo B |e investigator |4 oth | |
| 700 | 1 | |a Claramente Clausell, Berta |e investigator |4 oth | |
| 700 | 1 | |a Colas Rubio, Juan |e investigator |4 oth | |
| 700 | 1 | |a Cuesta Lopez, Fuensanta |e investigator |4 oth | |
| 700 | 1 | |a Culebras Cáceres, Carlos |e investigator |4 oth | |
| 700 | 1 | |a Ramos, Meliton Francisco Davila |e investigator |4 oth | |
| 700 | 1 | |a De Luis Fernandez, Maria del Pilar |e investigator |4 oth | |
| 700 | 1 | |a De Pilar, Marta |e investigator |4 oth | |
| 700 | 1 | |a Pérez, Félix Díaz |e investigator |4 oth | |
| 700 | 1 | |a Robert, Ignacio Durán |e investigator |4 oth | |
| 700 | 1 | |a Egido Herrero, José Antonio |e investigator |4 oth | |
| 700 | 1 | |a Escribano Soriano, José-Bernardo |e investigator |4 oth | |
| 700 | 1 | |a Escudier Villa, Juan Manuel |e investigator |4 oth | |
| 700 | 1 | |a Esmatjes, Enric |e investigator |4 oth | |
| 700 | 1 | |a Espinosa Plaza, Antonio Carlos |e investigator |4 oth | |
| 700 | 1 | |a Espinosa Rosso, Raúl |e investigator |4 oth | |
| 700 | 1 | |a Fernández, Camino |e investigator |4 oth | |
| 700 | 1 | |a Fernández Alvarez, Ovidio |e investigator |4 oth | |
| 700 | 1 | |a De la Cigoña, Fabriciano Fernández |e investigator |4 oth | |
| 700 | 1 | |a Fernández Lebrato, José Ramón |e investigator |4 oth | |
| 700 | 1 | |a Ferrero Ros, Marta |e investigator |4 oth | |
| 700 | 1 | |a Pedauyé, Antonio Flores |e investigator |4 oth | |
| 700 | 1 | |a Flores Ruiz, José-Jesús |e investigator |4 oth | |
| 700 | 1 | |a Rosa María, Folgado De la Fuente |e investigator |4 oth | |
| 700 | 1 | |a Formiga Pérez, Francesc |e investigator |4 oth | |
| 700 | 1 | |a Aranda, Carlos Franco |e investigator |4 oth | |
| 700 | 1 | |a Cebrian, Joaquín Franco |e investigator |4 oth | |
| 700 | 1 | |a Castroseiros, Evaristo Freire |e investigator |4 oth | |
| 700 | 1 | |a Zafra, Moisés Galán |e investigator |4 oth | |
| 700 | 1 | |a Pérez del Pulgar, Jesús Galiana |e investigator |4 oth | |
| 700 | 1 | |a García Colodro, José María |e investigator |4 oth | |
| 700 | 1 | |a García Corrales, Francisco |e investigator |4 oth | |
| 700 | 1 | |a De la villa Redondo, Bernardo García |e investigator |4 oth | |
| 700 | 1 | |a de Dios García Díaz, Juan |e investigator |4 oth | |
| 700 | 1 | |a González, Juan Pedro García |e investigator |4 oth | |
| 700 | 1 | |a García Gutiérrez, Gonzalo |e investigator |4 oth | |
| 700 | 1 | |a García Pérez, Bartolomé |e investigator |4 oth | |
| 700 | 1 | |a García Polo, Iluminada |e investigator |4 oth | |
| 700 | 1 | |a de Andoain Tays, José María García |e investigator |4 oth | |
| 700 | 1 | |a de Burgos De Rico, Fernando García |e investigator |4 oth | |
| 700 | 1 | |a García-Monco Carra, Juan Carlos |e investigator |4 oth | |
| 700 | 1 | |a Sclarsky, Daniel Eduardo Geffner |e investigator |4 oth | |
| 700 | 1 | |a Gesto Castromil, Ricardo |e investigator |4 oth | |
| 700 | 1 | |a Ubeda, Juan Miguel Giron |e investigator |4 oth | |
| 700 | 1 | |a Opacua, Ignacio Goikolea |e investigator |4 oth | |
| 700 | 1 | |a Gómez, Jesús |e investigator |4 oth | |
| 700 | 1 | |a Cerezo, Jorge Francisco Gómez |e investigator |4 oth | |
| 700 | 1 | |a Gómez Pérez, Fernando |e investigator |4 oth | |
| 700 | 1 | |a González Anglada, María Isabel |e investigator |4 oth | |
| 700 | 1 | |a González Cocina, Emilio |e investigator |4 oth | |
| 700 | 1 | |a González Gómez, Carlos |e investigator |4 oth | |
| 700 | 1 | |a González Masegosa, Alonso |e investigator |4 oth | |
| 700 | 1 | |a Hidalgo Ordoñez, María Luisa |e investigator |4 oth | |
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