Scatter-based magnetic resonance elastography
Elasticity is a sensitive measure of the microstructural constitution of soft biological tissues and increasingly used in diagnostic imaging. Magnetic resonance elastography (MRE) uniquely allows in vivo measurement of the shear elasticity of brain tissue. However, the spatial resolution of MRE is inherently limited as the transformation of shear wave patterns into elasticity maps requires the solution of inverse problems. Therefore, an MRE method is introduced that avoids inversion and instead exploits shear wave scattering at elastic interfaces between anatomical regions of different shear compliance. This compliance-weighted imaging (CWI) method can be used to evaluate the mechanical consistency of cerebral lesions or to measure relative stiffness differences between anatomical subregions of the brain. It is demonstrated that CWI-MRE is sensitive enough to reveal significant elasticity variations within inner brain parenchyma: the caudate nucleus (head) was stiffer than the lentiform nucleus and the thalamus by factors of 1.3 +/- 0.1 and 1.7 +/- 0.2, respectively (P < 0.001). CWI-MRE provides a unique method for characterizing brain tissue by identifying local stiffness variations.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2009 |
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| Erschienen: |
2009 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:54 |
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| Enthalten in: |
Physics in medicine and biology - 54(2009), 7 vom: 07. Apr., Seite 2229-41 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Papazoglou, Sebastian [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 12.06.2009 Date Revised 25.11.2016 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1088/0031-9155/54/7/025 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM187149569 |
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| 500 | |a Date Revised 25.11.2016 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Elasticity is a sensitive measure of the microstructural constitution of soft biological tissues and increasingly used in diagnostic imaging. Magnetic resonance elastography (MRE) uniquely allows in vivo measurement of the shear elasticity of brain tissue. However, the spatial resolution of MRE is inherently limited as the transformation of shear wave patterns into elasticity maps requires the solution of inverse problems. Therefore, an MRE method is introduced that avoids inversion and instead exploits shear wave scattering at elastic interfaces between anatomical regions of different shear compliance. This compliance-weighted imaging (CWI) method can be used to evaluate the mechanical consistency of cerebral lesions or to measure relative stiffness differences between anatomical subregions of the brain. It is demonstrated that CWI-MRE is sensitive enough to reveal significant elasticity variations within inner brain parenchyma: the caudate nucleus (head) was stiffer than the lentiform nucleus and the thalamus by factors of 1.3 +/- 0.1 and 1.7 +/- 0.2, respectively (P < 0.001). CWI-MRE provides a unique method for characterizing brain tissue by identifying local stiffness variations | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 700 | 1 | |a Xu, Chao |e verfasserin |4 aut | |
| 700 | 1 | |a Hamhaber, Uwe |e verfasserin |4 aut | |
| 700 | 1 | |a Siebert, Eberhard |e verfasserin |4 aut | |
| 700 | 1 | |a Bohner, Georg |e verfasserin |4 aut | |
| 700 | 1 | |a Klingebiel, Randolf |e verfasserin |4 aut | |
| 700 | 1 | |a Braun, Jürgen |e verfasserin |4 aut | |
| 700 | 1 | |a Sack, Ingolf |e verfasserin |4 aut | |
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