Changes in bone mineral density during therapy in childhood acute lymphoblastic leukemia
Quantitative computed tomography was performed to determine bone mineral density (BMD) at initial presentation and following 6-months of therapy in children with acute lymphoblastic leukemia (ALL). Of 46 children enrolled, the complete set of observations was available in 32. The combined mean BMD of three lumbar vertebrae at diagnosis and during treatment were 167.1+/-27.4 and 148.8+/-31.4 mg/ cm3, respectively (P=0.001). Twenty six children (81.2%) had a decrease in BMD on treatment. The mean BMD for each of 3 vertebrae declined as well. The mean T-scores at diagnosis and during therapy were -0.15+/-0.9 and -0.86+/-1.0, respectively (P=0.001). Conventional radiographs revealed metaphyseal lucencies which were replaced with metaphyseal dense bands with therapy. To conclude, there was a significant reduction of BMD in children with ALL following 6- months of treatment.
| Errataetall: |
CommentIn: Indian Pediatr. 2009 Jun;46(6):542-3; author reply 543-4. - PMID 19556673 |
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| Medienart: |
Artikel |
| Erscheinungsjahr: |
2009 |
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| Erschienen: |
2009 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:46 |
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| Enthalten in: |
Indian pediatrics - 46(2009), 3 vom: 13. März, Seite 245-8 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kaushik, Ashlesha [VerfasserIn] |
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| Themen: |
5J49Q6B70F |
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| Anmerkungen: |
Date Completed 02.11.2009 Date Revised 25.11.2016 published: Print-Electronic CommentIn: Indian Pediatr. 2009 Jun;46(6):542-3; author reply 543-4. - PMID 19556673 Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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NLM186403356 |
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| 500 | |a CommentIn: Indian Pediatr. 2009 Jun;46(6):542-3; author reply 543-4. - PMID 19556673 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Quantitative computed tomography was performed to determine bone mineral density (BMD) at initial presentation and following 6-months of therapy in children with acute lymphoblastic leukemia (ALL). Of 46 children enrolled, the complete set of observations was available in 32. The combined mean BMD of three lumbar vertebrae at diagnosis and during treatment were 167.1+/-27.4 and 148.8+/-31.4 mg/ cm3, respectively (P=0.001). Twenty six children (81.2%) had a decrease in BMD on treatment. The mean BMD for each of 3 vertebrae declined as well. The mean T-scores at diagnosis and during therapy were -0.15+/-0.9 and -0.86+/-1.0, respectively (P=0.001). Conventional radiographs revealed metaphyseal lucencies which were replaced with metaphyseal dense bands with therapy. To conclude, there was a significant reduction of BMD in children with ALL following 6- months of treatment | ||
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