Clinical outcome and predictive factors of recurrence among patients with Kikuchi's disease
OBJECTIVES: To evaluate the clinical outcome and predictive factors of recurrence among patients with Kikuchi's disease.
METHODS: Between January 2001 and December 2006, all patients with Kikuchi's disease were included in the study. Data were collected on co-morbidities, clinical manifestations, and ultrasound/laboratory findings, and the differences were compared between recurrent disease and non-recurrent disease groups.
RESULTS: The study included 102 patients with a mean age of 26.7 years. Among these patients, three developed systemic lupus erythematosus during the follow-up period, while two cases were later associated with tuberculosis. Eight patients (7.8%) experienced early relapse and 13 (12.7%) showed late recurrence. Patients with recurrent episodes were more likely to have fever and fatigue with extranodal involvement. Compared to the non-recurrent cases, recurrent cases remained symptomatic for a rather longer duration. The positive rate of the fluorescence anti-nuclear antibody (FANA) test was significantly higher in the recurrent disease group compared to the non-recurrent disease group.
CONCLUSIONS: Kikuchi's disease took a self-limiting clinical course in most cases, but the recurrence rate found in the present study was higher than that of previous reports. Kikuchi's disease might be a phenotype of diverse disease entities. The prognosis is different according to the underlying cause. The FANA test would be useful in predicting recurrence.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2009 |
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| Erschienen: |
2009 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:13 |
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| Enthalten in: |
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases - 13(2009), 3 vom: 01. Mai, Seite 322-6 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Song, Joon Young [VerfasserIn] |
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| Links: |
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| Themen: |
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| Anmerkungen: |
Date Completed 17.07.2009 Date Revised 24.04.2009 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.ijid.2008.06.022 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM186351135 |
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| 100 | 1 | |a Song, Joon Young |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Clinical outcome and predictive factors of recurrence among patients with Kikuchi's disease |
| 264 | 1 | |c 2009 | |
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| 500 | |a Date Completed 17.07.2009 | ||
| 500 | |a Date Revised 24.04.2009 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVES: To evaluate the clinical outcome and predictive factors of recurrence among patients with Kikuchi's disease | ||
| 520 | |a METHODS: Between January 2001 and December 2006, all patients with Kikuchi's disease were included in the study. Data were collected on co-morbidities, clinical manifestations, and ultrasound/laboratory findings, and the differences were compared between recurrent disease and non-recurrent disease groups | ||
| 520 | |a RESULTS: The study included 102 patients with a mean age of 26.7 years. Among these patients, three developed systemic lupus erythematosus during the follow-up period, while two cases were later associated with tuberculosis. Eight patients (7.8%) experienced early relapse and 13 (12.7%) showed late recurrence. Patients with recurrent episodes were more likely to have fever and fatigue with extranodal involvement. Compared to the non-recurrent cases, recurrent cases remained symptomatic for a rather longer duration. The positive rate of the fluorescence anti-nuclear antibody (FANA) test was significantly higher in the recurrent disease group compared to the non-recurrent disease group | ||
| 520 | |a CONCLUSIONS: Kikuchi's disease took a self-limiting clinical course in most cases, but the recurrence rate found in the present study was higher than that of previous reports. Kikuchi's disease might be a phenotype of diverse disease entities. The prognosis is different according to the underlying cause. The FANA test would be useful in predicting recurrence | ||
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Antibodies, Antinuclear |2 NLM | |
| 700 | 1 | |a Lee, Jacob |e verfasserin |4 aut | |
| 700 | 1 | |a Park, Dae Won |e verfasserin |4 aut | |
| 700 | 1 | |a Sohn, Jang Wook |e verfasserin |4 aut | |
| 700 | 1 | |a Suh, Sang Il |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, In Sun |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Woo Joo |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Min Ja |e verfasserin |4 aut | |
| 700 | 1 | |a Cheong, Hee Jin |e verfasserin |4 aut | |
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| 773 | 1 | 8 | |g volume:13 |g year:2009 |g number:3 |g day:01 |g month:05 |g pages:322-6 |
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