Replication capacity in relation to immunologic and virologic outcomes in HIV-1-infected treatment-naive subjects
OBJECTIVES: To evaluate the association between baseline (BL) replication capacity (RC) (RCBL) and immunologic/virologic parameters (at BL and after 48 weeks on therapy) in HIV-1-infected subjects initiating antiretroviral therapy.
METHODS: RCBL was determined using a modified Monogram PhenoSense HIV drug susceptibility assay on plasma HIV-1 from 321 treatment-naive subjects from AIDS Clinical Trials Group 384. Univariate and multivariable analyses were performed to determine the association of RCBL with BL and on-therapy virologic and immunologic outcomes.
RESULTS: Higher RCBL was associated with lower baseline CD4 (CD4BL) (r = -0.23, P < 0.0001), higher baseline HIV-1 RNA (r = 0.25, P < 0.0001), higher CD4BL activation percent (r = 0.23, P < 0.0001), and lower CD4BL memory count (r = -0.21, P = 0.0002). In a multivariable model, week 48 CD4 increase (DeltaCD448) was associated with lower CD4BL memory count and higher CD4BL-naive percent (P = 0.004, P = 0.015, respectively). The interaction between CD4BL and RCBL was significant (P = 0.018), with a positive association between RCBL and DeltaCD448 in subjects with higher CD4BL and a negative association at lower absCD4BL.
CONCLUSIONS: At baseline, higher RC was significantly associated with higher HIV-1 RNA, higher CD4 cell activation, lower CD4 cell count, and lower CD4 memory cell count. These factors may interact, directly or indirectly, to modify the extent to which CD4 recovery occurs in patients starting antiretroviral therapy at different CD4BL counts.
| Errataetall: |
ErratumIn: J Acquir Immune Defic Syndr. 2009 Jun 1;51(2):238 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2009 |
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| Erschienen: |
2009 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:50 |
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| Enthalten in: |
Journal of acquired immune deficiency syndromes (1999) - 50(2009), 3 vom: 01. März, Seite 250-8 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Skowron, Gail [VerfasserIn] |
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| Links: |
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| Themen: |
Journal Article |
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| Anmerkungen: |
Date Completed 30.03.2009 Date Revised 20.10.2021 published: Print ErratumIn: J Acquir Immune Defic Syndr. 2009 Jun 1;51(2):238 Citation Status MEDLINE |
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| doi: |
10.1097/QAI.0b013e3181938faf |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM186218346 |
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| 024 | 7 | |a 10.1097/QAI.0b013e3181938faf |2 doi | |
| 028 | 5 | 2 | |a pubmed24n0621.xml |
| 035 | |a (DE-627)NLM186218346 | ||
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| 041 | |a eng | ||
| 100 | 1 | |a Skowron, Gail |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Replication capacity in relation to immunologic and virologic outcomes in HIV-1-infected treatment-naive subjects |
| 264 | 1 | |c 2009 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 30.03.2009 | ||
| 500 | |a Date Revised 20.10.2021 | ||
| 500 | |a published: Print | ||
| 500 | |a ErratumIn: J Acquir Immune Defic Syndr. 2009 Jun 1;51(2):238 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVES: To evaluate the association between baseline (BL) replication capacity (RC) (RCBL) and immunologic/virologic parameters (at BL and after 48 weeks on therapy) in HIV-1-infected subjects initiating antiretroviral therapy | ||
| 520 | |a METHODS: RCBL was determined using a modified Monogram PhenoSense HIV drug susceptibility assay on plasma HIV-1 from 321 treatment-naive subjects from AIDS Clinical Trials Group 384. Univariate and multivariable analyses were performed to determine the association of RCBL with BL and on-therapy virologic and immunologic outcomes | ||
| 520 | |a RESULTS: Higher RCBL was associated with lower baseline CD4 (CD4BL) (r = -0.23, P < 0.0001), higher baseline HIV-1 RNA (r = 0.25, P < 0.0001), higher CD4BL activation percent (r = 0.23, P < 0.0001), and lower CD4BL memory count (r = -0.21, P = 0.0002). In a multivariable model, week 48 CD4 increase (DeltaCD448) was associated with lower CD4BL memory count and higher CD4BL-naive percent (P = 0.004, P = 0.015, respectively). The interaction between CD4BL and RCBL was significant (P = 0.018), with a positive association between RCBL and DeltaCD448 in subjects with higher CD4BL and a negative association at lower absCD4BL | ||
| 520 | |a CONCLUSIONS: At baseline, higher RC was significantly associated with higher HIV-1 RNA, higher CD4 cell activation, lower CD4 cell count, and lower CD4 memory cell count. These factors may interact, directly or indirectly, to modify the extent to which CD4 recovery occurs in patients starting antiretroviral therapy at different CD4BL counts | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Randomized Controlled Trial | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 700 | 1 | |a Spritzler, John G |e verfasserin |4 aut | |
| 700 | 1 | |a Weidler, Jodi |e verfasserin |4 aut | |
| 700 | 1 | |a Robbins, Gregory K |e verfasserin |4 aut | |
| 700 | 1 | |a Johnson, Victoria A |e verfasserin |4 aut | |
| 700 | 1 | |a Chan, Ellen S |e verfasserin |4 aut | |
| 700 | 1 | |a Asmuth, David M |e verfasserin |4 aut | |
| 700 | 1 | |a Gandhi, Rajesh T |e verfasserin |4 aut | |
| 700 | 1 | |a Lie, Yolanda |e verfasserin |4 aut | |
| 700 | 1 | |a Bates, Michael |e verfasserin |4 aut | |
| 700 | 1 | |a Pollard, Richard B |e verfasserin |4 aut | |
| 700 | 0 | |a NIH/NIAID ACTG 384 Protocol Team and Monogram Biosciences |e verfasserin |4 aut | |
| 700 | 1 | |a Vella, Stefano |e investigator |4 oth | |
| 700 | 1 | |a Chiesi, Chiesi |e investigator |4 oth | |
| 700 | 1 | |a Arcieri, Romano |e investigator |4 oth | |
| 700 | 1 | |a Pirillo, Maria Franca |e investigator |4 oth | |
| 700 | 1 | |a Galluzzo, Clementina Maria |e investigator |4 oth | |
| 700 | 1 | |a Pia Germinario, Elena Angela |e investigator |4 oth | |
| 700 | 1 | |a Amici, Roberta |e investigator |4 oth | |
| 700 | 1 | |a Marzi, Massimo |e investigator |4 oth | |
| 700 | 1 | |a Nobile, Anna |e investigator |4 oth | |
| 700 | 1 | |a Di Nallo, Rossella |e investigator |4 oth | |
| 700 | 1 | |a Polizzi, Cosimo |e investigator |4 oth | |
| 700 | 1 | |a Coronado, Olga |e investigator |4 oth | |
| 700 | 1 | |a Fasulo, Giovanni |e investigator |4 oth | |
| 700 | 1 | |a Carosi, Giampiero |e investigator |4 oth | |
| 700 | 1 | |a Castelli, Francesco |e investigator |4 oth | |
| 700 | 1 | |a Di Pietro, Massimo |e investigator |4 oth | |
| 700 | 1 | |a Vichi-Ospedale, Francesca |e investigator |4 oth | |
| 700 | 1 | |a Sterrantino, Gaetana |e investigator |4 oth | |
| 700 | 1 | |a Ambu, Silvia |e investigator |4 oth | |
| 700 | 1 | |a Cargnel, Antonietta |e investigator |4 oth | |
| 700 | 1 | |a Meraviglia, Paola |e investigator |4 oth | |
| 700 | 1 | |a Niero, Fosca |e investigator |4 oth | |
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| 700 | 1 | |a d'Arminio Monforte, Antonella |e investigator |4 oth | |
| 700 | 1 | |a Sollima, Salvatore |e investigator |4 oth | |
| 700 | 1 | |a Balotta, Claudia |e investigator |4 oth | |
| 700 | 1 | |a Delia, Salvatore |e investigator |4 oth | |
| 700 | 1 | |a Ciardi, Maria |e investigator |4 oth | |
| 700 | 1 | |a Soranzo, Maria Luisa |e investigator |4 oth | |
| 700 | 1 | |a Macor, Antonio |e investigator |4 oth | |
| 700 | 1 | |a d'Ettorre, Gabriella |e investigator |4 oth | |
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| 700 | 1 | |a Santoro, Domenico |e investigator |4 oth | |
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| 700 | 1 | |a Borderi, Marco |e investigator |4 oth | |
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| 700 | 1 | |a Ferrari, Carlo |e investigator |4 oth | |
| 700 | 1 | |a Pasetti, Giancarlo |e investigator |4 oth | |
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| 700 | 1 | |a Magnani, Giacomo |e investigator |4 oth | |
| 700 | 1 | |a Zoboli, Giuliana |e investigator |4 oth | |
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