HIV/HCV coinfection at an university hospital in Recife, Brazil
OBJECTIVE: To estimate the prevalence of hepatitis C virus (HCV) infection and risks factors associated with coinfection in HIV-positive individuals.
METHODS: A cross-sectional descriptive study was conducted with 343 HIV patients attended at a university hospital in Recife, Northeastern Brazil, from March to December 2003. A standardized questionnaire about risk factors was administered. Serum samples were analyzed for anti-HCV antibodies using enzyme-linked immunosorbent assay (ELISA), HCV-RNA using reverse transcription-polymerase chain reaction (RT-PCR), and genotyping using the ABI 377 (PE Biosystems). Univariate and multivariate analyses and multiple logistic regression were performed.
RESULTS: HCV prevalence was 4.1% (14/343) using ELISA and 3.2% (11/343) using RT-PCR. The most common genotypes were 1b (45%), 3 (33%) and 1a (22%). Co-infection was higher among those aged 30 to 39 years, and predominantly in males (64.3 %). In the multiple logistic regression, the variable blood transfusion was the single remaining risk factor for HCV (OR=4.28; 95% CI 1.44;12.73).
CONCLUSIONS: The prevalence of HIV/HCV coinfection was low. Blood transfusion was a risk factor and HCV genotype 1b was the most frequently found.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2009 |
|---|---|
| Erschienen: |
2009 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:43 |
|---|---|
| Enthalten in: |
Revista de saude publica - 43(2009), 1 vom: 01. Feb., Seite 133-9 |
| Sprache: |
Portugiesisch |
|---|
| Weiterer Titel: |
Co-infecção por HIV/HCV em hospital universitário de Recife, Brasil |
|---|
| Beteiligte Personen: |
Carvalho, Flávia Helena Pontes de [VerfasserIn] |
|---|
| Themen: |
|---|
| Anmerkungen: |
Date Completed 30.06.2009 Date Revised 06.06.2019 published: Print Citation Status MEDLINE |
|---|
| Förderinstitution / Projekttitel: |
|
|---|
| PPN (Katalog-ID): |
NLM185989349 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM185989349 | ||
| 003 | DE-627 | ||
| 005 | 20231223173443.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231223s2009 xx |||||o 00| ||por c | ||
| 028 | 5 | 2 | |a pubmed24n0620.xml |
| 035 | |a (DE-627)NLM185989349 | ||
| 035 | |a (NLM)19169585 | ||
| 035 | |a (PII)S0034-89102009000100017 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a por | ||
| 100 | 1 | |a Carvalho, Flávia Helena Pontes de |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a HIV/HCV coinfection at an university hospital in Recife, Brazil |
| 246 | 3 | 3 | |a Co-infecção por HIV/HCV em hospital universitário de Recife, Brasil |
| 264 | 1 | |c 2009 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 30.06.2009 | ||
| 500 | |a Date Revised 06.06.2019 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVE: To estimate the prevalence of hepatitis C virus (HCV) infection and risks factors associated with coinfection in HIV-positive individuals | ||
| 520 | |a METHODS: A cross-sectional descriptive study was conducted with 343 HIV patients attended at a university hospital in Recife, Northeastern Brazil, from March to December 2003. A standardized questionnaire about risk factors was administered. Serum samples were analyzed for anti-HCV antibodies using enzyme-linked immunosorbent assay (ELISA), HCV-RNA using reverse transcription-polymerase chain reaction (RT-PCR), and genotyping using the ABI 377 (PE Biosystems). Univariate and multivariate analyses and multiple logistic regression were performed | ||
| 520 | |a RESULTS: HCV prevalence was 4.1% (14/343) using ELISA and 3.2% (11/343) using RT-PCR. The most common genotypes were 1b (45%), 3 (33%) and 1a (22%). Co-infection was higher among those aged 30 to 39 years, and predominantly in males (64.3 %). In the multiple logistic regression, the variable blood transfusion was the single remaining risk factor for HCV (OR=4.28; 95% CI 1.44;12.73) | ||
| 520 | |a CONCLUSIONS: The prevalence of HIV/HCV coinfection was low. Blood transfusion was a risk factor and HCV genotype 1b was the most frequently found | ||
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Hepatitis C Antibodies |2 NLM | |
| 650 | 7 | |a RNA, Viral |2 NLM | |
| 700 | 1 | |a Coêlho, Maria Rosângela Cunha Duarte |e verfasserin |4 aut | |
| 700 | 1 | |a Vilella, Tatiana de Aguiar Santos |e verfasserin |4 aut | |
| 700 | 1 | |a Silva, Jéfferson Luis Almeida |e verfasserin |4 aut | |
| 700 | 1 | |a Melo, Heloísa Ramos de Lacerda |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Revista de saude publica |d 1967 |g 43(2009), 1 vom: 01. Feb., Seite 133-9 |w (DE-627)NLM000513679 |x 1518-8787 |7 nnns |
| 773 | 1 | 8 | |g volume:43 |g year:2009 |g number:1 |g day:01 |g month:02 |g pages:133-9 |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 43 |j 2009 |e 1 |b 01 |c 02 |h 133-9 | ||