Natural course of knee osteoarthritis in middle-aged subjects with knee pain : 12-year follow-up using clinical and radiographic criteria
OBJECTIVE: To explore the natural course of knee osteoarthritis (OA) in a middle-aged population with chronic knee pain.
METHODS: A population-based sample of 143 subjects (mean age 45 (range 35-54), 44% women) with knee pain (>3 months) at inclusion was studied. Weight-bearing posteroanterior tibiofemoral (TF) radiographs were obtained at baseline and 12 years later, and classified according to Kellgren/Lawrence (K/L). Patellofemoral (PF) OA was determined at 5- and 12-years' follow-up using a skyline view and a cut-off point of <5 mm joint space width. The ACR clinical criteria were used at baseline.
RESULTS: Seventy-six (53%) had no TF OA (K/L 0) at baseline, but 49 had clinical OA. Overall, 65/76 (86%) developed incident TF OA over 12 years (K/L >or=1): 44/49 (90%) of the subjects with clinical OA and 21/27 (78%) without clinical OA. Progression was found in 65/67 (97%) with TF OA at baseline. Of the 84 with no PF OA at the 5-year examination, 26 (31%) developed PF OA over 7 years.
CONCLUSION: A majority of the subjects with chronic knee pain developed knee OA over 12 years. It is concluded that knee pain is often the first sign of knee OA.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2009 |
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| Erschienen: |
2009 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:68 |
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| Enthalten in: |
Annals of the rheumatic diseases - 68(2009), 12 vom: 30. Dez., Seite 1890-3 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Thorstensson, C A [VerfasserIn] |
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| Links: |
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| Themen: |
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| Anmerkungen: |
Date Completed 31.12.2009 Date Revised 21.03.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1136/ard.2008.095158 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM184919444 |
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| 100 | 1 | |a Thorstensson, C A |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Natural course of knee osteoarthritis in middle-aged subjects with knee pain |b 12-year follow-up using clinical and radiographic criteria |
| 264 | 1 | |c 2009 | |
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| 500 | |a Date Completed 31.12.2009 | ||
| 500 | |a Date Revised 21.03.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVE: To explore the natural course of knee osteoarthritis (OA) in a middle-aged population with chronic knee pain | ||
| 520 | |a METHODS: A population-based sample of 143 subjects (mean age 45 (range 35-54), 44% women) with knee pain (>3 months) at inclusion was studied. Weight-bearing posteroanterior tibiofemoral (TF) radiographs were obtained at baseline and 12 years later, and classified according to Kellgren/Lawrence (K/L). Patellofemoral (PF) OA was determined at 5- and 12-years' follow-up using a skyline view and a cut-off point of <5 mm joint space width. The ACR clinical criteria were used at baseline | ||
| 520 | |a RESULTS: Seventy-six (53%) had no TF OA (K/L 0) at baseline, but 49 had clinical OA. Overall, 65/76 (86%) developed incident TF OA over 12 years (K/L >or=1): 44/49 (90%) of the subjects with clinical OA and 21/27 (78%) without clinical OA. Progression was found in 65/67 (97%) with TF OA at baseline. Of the 84 with no PF OA at the 5-year examination, 26 (31%) developed PF OA over 7 years | ||
| 520 | |a CONCLUSION: A majority of the subjects with chronic knee pain developed knee OA over 12 years. It is concluded that knee pain is often the first sign of knee OA | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 700 | 1 | |a Andersson, M L E |e verfasserin |4 aut | |
| 700 | 1 | |a Jönsson, H |e verfasserin |4 aut | |
| 700 | 1 | |a Saxne, T |e verfasserin |4 aut | |
| 700 | 1 | |a Petersson, I F |e verfasserin |4 aut | |
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