Occult chronic kidney disease in patients with stable coronary heart disease
BACKGROUND AND OBJECTIVE: Chronic kidney disease (CKD) increases cardiovascular risk mainly in subjects with coronary heart disease. The aim of this study was to evaluate the prevalence of occult CKD (OCKD) in stable coronary heart disease patients and to study the factors associated in order to improve its detection.
PATIENTS AND METHOD: Cross sectional study of 7,884 patients who had had a coronary event requiring hospitalization in the previous 6 months to 10 years. Glomerular filtration rate was estimated by means of the Modification of Diet in Renal Disease (MDRD) study equation. CKD was defined as a glomerular filtration rate lower than 60 ml/min/1.73 m(2), and OCKD when, in addition, serum creatinine was < 133 mmol/l in men and < 124 mmol/l in women.
RESULTS: The mean age was 65.3 years, 73.7% male and 22.4% had CKD, 68.3% of them with normal serum creatinine. In subjects with OCKD the prevalence of risk factors and cardiovascular diseases associated was intermediate between subjects without CKD and subjects with CKD and high serum creatinine. Age, female sex, hypertension, diabetes, heart failure, cerebrovascular disease and peripheral artery disease were significantly and independently associated with OCKD in the multivariate analysis.
CONCLUSIONS: Almost one in 4 subjects with stable coronary heart disease had CKD, most of them with normal serum creatinine, mainly women and older patients.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2008 |
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| Erschienen: |
2008 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:131 |
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| Enthalten in: |
Medicina clinica - 131(2008), 7 vom: 06. Sept., Seite 241-4 |
| Sprache: |
Spanisch |
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| Weiterer Titel: |
Insuficiencia renal crónica oculta en pacientes con enfermedad coronaria estable |
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| Beteiligte Personen: |
Lahoz, Carlos [VerfasserIn] |
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| Themen: |
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| Anmerkungen: |
Date Completed 15.01.2009 Date Revised 23.08.2019 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM182272109 |
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| 245 | 1 | 0 | |a Occult chronic kidney disease in patients with stable coronary heart disease |
| 246 | 3 | 3 | |a Insuficiencia renal crónica oculta en pacientes con enfermedad coronaria estable |
| 264 | 1 | |c 2008 | |
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| 500 | |a Date Completed 15.01.2009 | ||
| 500 | |a Date Revised 23.08.2019 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND AND OBJECTIVE: Chronic kidney disease (CKD) increases cardiovascular risk mainly in subjects with coronary heart disease. The aim of this study was to evaluate the prevalence of occult CKD (OCKD) in stable coronary heart disease patients and to study the factors associated in order to improve its detection | ||
| 520 | |a PATIENTS AND METHOD: Cross sectional study of 7,884 patients who had had a coronary event requiring hospitalization in the previous 6 months to 10 years. Glomerular filtration rate was estimated by means of the Modification of Diet in Renal Disease (MDRD) study equation. CKD was defined as a glomerular filtration rate lower than 60 ml/min/1.73 m(2), and OCKD when, in addition, serum creatinine was < 133 mmol/l in men and < 124 mmol/l in women | ||
| 520 | |a RESULTS: The mean age was 65.3 years, 73.7% male and 22.4% had CKD, 68.3% of them with normal serum creatinine. In subjects with OCKD the prevalence of risk factors and cardiovascular diseases associated was intermediate between subjects without CKD and subjects with CKD and high serum creatinine. Age, female sex, hypertension, diabetes, heart failure, cerebrovascular disease and peripheral artery disease were significantly and independently associated with OCKD in the multivariate analysis | ||
| 520 | |a CONCLUSIONS: Almost one in 4 subjects with stable coronary heart disease had CKD, most of them with normal serum creatinine, mainly women and older patients | ||
| 650 | 4 | |a English Abstract | |
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Mostaza, José M |e verfasserin |4 aut | |
| 700 | 1 | |a Mantilla, María Teresa |e verfasserin |4 aut | |
| 700 | 1 | |a Taboada, Manuel |e verfasserin |4 aut | |
| 700 | 1 | |a Tranche, Salvador |e verfasserin |4 aut | |
| 700 | 1 | |a Martín-Jadraque, Raquel |e verfasserin |4 aut | |
| 700 | 1 | |a López-Rodríguez, Isidro |e verfasserin |4 aut | |
| 700 | 1 | |a Monteiro, Beatriz |e verfasserin |4 aut | |
| 700 | 1 | |a Sánchez-Zamorano, Miguel A |e verfasserin |4 aut | |
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