8-Biarylchromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK)
The synthesis and biological evaluation of libraries of 8-biarylchromen-4-ones enabled the elucidation of structure-activity relationships for inhibition of the DNA-dependent protein kinase (DNA-PK), with 8-(3-(thiophen-2-yl)phenyl)chromen-4-one and 8-(3-(thiophen-3-yl)phenyl)chromen-4-one being especially potent inhibitors.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2008 |
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| Erschienen: |
2008 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:18 |
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| Enthalten in: |
Bioorganic & medicinal chemistry letters - 18(2008), 17 vom: 01. Sept., Seite 4885-90 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Desage-El Murr, Marine [VerfasserIn] |
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| Links: |
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| Themen: |
Chromones |
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| Anmerkungen: |
Date Completed 27.10.2008 Date Revised 19.11.2009 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.bmcl.2008.07.066 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM181360039 |
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| 500 | |a Date Revised 19.11.2009 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a The synthesis and biological evaluation of libraries of 8-biarylchromen-4-ones enabled the elucidation of structure-activity relationships for inhibition of the DNA-dependent protein kinase (DNA-PK), with 8-(3-(thiophen-2-yl)phenyl)chromen-4-one and 8-(3-(thiophen-3-yl)phenyl)chromen-4-one being especially potent inhibitors | ||
| 650 | 4 | |a Comparative Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Chromones |2 NLM | |
| 650 | 7 | |a Protein Kinase Inhibitors |2 NLM | |
| 650 | 7 | |a Radiation-Sensitizing Agents |2 NLM | |
| 650 | 7 | |a DNA-Activated Protein Kinase |2 NLM | |
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| 700 | 1 | |a Cano, Celine |e verfasserin |4 aut | |
| 700 | 1 | |a Golding, Bernard T |e verfasserin |4 aut | |
| 700 | 1 | |a Hardcastle, Ian R |e verfasserin |4 aut | |
| 700 | 1 | |a Hummersome, Marc |e verfasserin |4 aut | |
| 700 | 1 | |a Frigerio, Mark |e verfasserin |4 aut | |
| 700 | 1 | |a Curtin, Nicola J |e verfasserin |4 aut | |
| 700 | 1 | |a Menear, Keith |e verfasserin |4 aut | |
| 700 | 1 | |a Richardson, Caroline |e verfasserin |4 aut | |
| 700 | 1 | |a Smith, Graeme C M |e verfasserin |4 aut | |
| 700 | 1 | |a Griffin, Roger J |e verfasserin |4 aut | |
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