Delayed blink reflex in dementia with Lewy bodies is sensitive to cholinergic modulation
OBJECTIVES: To assess the possible responsiveness of blink reflex alterations present in dementia with Lewy bodies (DLB) to treatment with cholinesterase inhibitors.
METHODS: Twenty-six patients with DLB and 20 patients with Alzheimer disease underwent clinical, neuropsychological (including assessment of cognitive fluctuations, with the Cognitive Assessment of Fluctuations and the One-Day Fluctuation Assessment questionnaires), and the blink reflex evaluation at baseline, 1 week after vitamin E administration (to assess test-retest reliability), and 1 and 2 weeks after donepezil administration at the dose of 10 mg/d. Results were compared with data obtained from 30 healthy controls treated with vitamin E capsules for 2 weeks.
RESULTS: Treatment with donepezil did not cause modifications of cognitive or motor performances in both groups of patients. In DLB patients, One-Day Fluctuation Assessment scores were modified by donepezil treatment with a mean reduction of 2.8 +/- 1.8 compared with baseline (P < 0.05). After 2 weeks of treatment with donepezil, R2 latency was significantly decreased in DLB patients. The mean R2 latency reduction was by 3.0 +/- 3.2 milliseconds (P < 0.0001 compared with baseline). R2 mean latency reduction was significantly correlated with R2 mean latency delay at baseline (Spearman rho = 0.8).
CONCLUSIONS: Short-term donepezil administration can correct the alterations of the blink response together with the daily occurrence of cognitive fluctuations present in DLB patients.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2008 |
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| Erschienen: |
2008 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:31 |
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| Enthalten in: |
Clinical neuropharmacology - 31(2008), 4 vom: 20. Juli, Seite 231-7 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Anzellotti, Francesca [VerfasserIn] |
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| Links: |
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| Themen: |
1406-18-4 |
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| Anmerkungen: |
Date Completed 09.10.2008 Date Revised 01.12.2018 published: Print Citation Status MEDLINE |
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| doi: |
10.1097/WNF.0b013e31815e5d7f |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM18129009X |
|---|
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| 245 | 1 | 0 | |a Delayed blink reflex in dementia with Lewy bodies is sensitive to cholinergic modulation |
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| 500 | |a Date Completed 09.10.2008 | ||
| 500 | |a Date Revised 01.12.2018 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVES: To assess the possible responsiveness of blink reflex alterations present in dementia with Lewy bodies (DLB) to treatment with cholinesterase inhibitors | ||
| 520 | |a METHODS: Twenty-six patients with DLB and 20 patients with Alzheimer disease underwent clinical, neuropsychological (including assessment of cognitive fluctuations, with the Cognitive Assessment of Fluctuations and the One-Day Fluctuation Assessment questionnaires), and the blink reflex evaluation at baseline, 1 week after vitamin E administration (to assess test-retest reliability), and 1 and 2 weeks after donepezil administration at the dose of 10 mg/d. Results were compared with data obtained from 30 healthy controls treated with vitamin E capsules for 2 weeks | ||
| 520 | |a RESULTS: Treatment with donepezil did not cause modifications of cognitive or motor performances in both groups of patients. In DLB patients, One-Day Fluctuation Assessment scores were modified by donepezil treatment with a mean reduction of 2.8 +/- 1.8 compared with baseline (P < 0.05). After 2 weeks of treatment with donepezil, R2 latency was significantly decreased in DLB patients. The mean R2 latency reduction was by 3.0 +/- 3.2 milliseconds (P < 0.0001 compared with baseline). R2 mean latency reduction was significantly correlated with R2 mean latency delay at baseline (Spearman rho = 0.8) | ||
| 520 | |a CONCLUSIONS: Short-term donepezil administration can correct the alterations of the blink response together with the daily occurrence of cognitive fluctuations present in DLB patients | ||
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Antioxidants |2 NLM | |
| 650 | 7 | |a Cholinesterase Inhibitors |2 NLM | |
| 650 | 7 | |a Indans |2 NLM | |
| 650 | 7 | |a Piperidines |2 NLM | |
| 650 | 7 | |a Vitamin E |2 NLM | |
| 650 | 7 | |a 1406-18-4 |2 NLM | |
| 650 | 7 | |a Donepezil |2 NLM | |
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| 700 | 1 | |a Bonanni, Laura |e verfasserin |4 aut | |
| 700 | 1 | |a Iorio, Eva |e verfasserin |4 aut | |
| 700 | 1 | |a Di Baldassarre, Fabiana |e verfasserin |4 aut | |
| 700 | 1 | |a D'Andreagiovanni, Anna |e verfasserin |4 aut | |
| 700 | 1 | |a Monaco, Daniela |e verfasserin |4 aut | |
| 700 | 1 | |a Thomas, Astrid |e verfasserin |4 aut | |
| 700 | 1 | |a Onofrj, Marco |e verfasserin |4 aut | |
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