Pediatric standard-risk AML with fully matched sibling donors : to transplant in first CR or not?
Allogeneic hematopoietic SCT (HSCT) for children with standard-risk AML in first CR (CR1) is controversial. We reviewed 32 consecutive children with standard-risk AML who received matched sibling donor HSCT in CR1 from 1995 to 2004. With a median follow-up of 76 months (range: 36-114), 3 year EFS was 0.74 (95% confidence interval (CI): 0.57-0.88) and the overall survival was 0.81 (95% CI: 0.66-0.93). Only one patient died as a result of TRM. Larger studies, such as the MRC-UK 10 and 12, reported 60-62% EFS. Outcome of children with standard-risk AML transplanted from a matched sibling donor in CR1 is very encouraging with minimal toxicity.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2008 |
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| Erschienen: |
2008 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:42 |
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| Enthalten in: |
Bone marrow transplantation - 42(2008), 6 vom: 28. Sept., Seite 393-6 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Gassas, A [VerfasserIn] |
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| Links: |
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| Themen: |
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| Anmerkungen: |
Date Completed 10.03.2009 Date Revised 24.09.2008 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1038/bmt.2008.182 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM180529811 |
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| 245 | 1 | 0 | |a Pediatric standard-risk AML with fully matched sibling donors |b to transplant in first CR or not? |
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| 500 | |a Date Completed 10.03.2009 | ||
| 500 | |a Date Revised 24.09.2008 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Allogeneic hematopoietic SCT (HSCT) for children with standard-risk AML in first CR (CR1) is controversial. We reviewed 32 consecutive children with standard-risk AML who received matched sibling donor HSCT in CR1 from 1995 to 2004. With a median follow-up of 76 months (range: 36-114), 3 year EFS was 0.74 (95% confidence interval (CI): 0.57-0.88) and the overall survival was 0.81 (95% CI: 0.66-0.93). Only one patient died as a result of TRM. Larger studies, such as the MRC-UK 10 and 12, reported 60-62% EFS. Outcome of children with standard-risk AML transplanted from a matched sibling donor in CR1 is very encouraging with minimal toxicity | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Afzal, S |e verfasserin |4 aut | |
| 700 | 1 | |a Ishaqi, M K |e verfasserin |4 aut | |
| 700 | 1 | |a Finkelstein-Shechter, T |e verfasserin |4 aut | |
| 700 | 1 | |a Rojas, M |e verfasserin |4 aut | |
| 700 | 1 | |a Dupuis, A |e verfasserin |4 aut | |
| 700 | 1 | |a Sung, L |e verfasserin |4 aut | |
| 700 | 1 | |a Doyle, J |e verfasserin |4 aut | |
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