Growth hormone (GH) treatment does not restore endothelial function in children with GH deficiency
BACKGROUND: In adults with growth hormone (GH) deficiency (GHD), GH treatment restores impaired endothelial function, a precursor of cardiovascular disease. Its effect in children with GHD is unknown.
METHODS: Three months of GH (0.3 mg/kg/wk) were given to nine children with GHD. Endothelial function was measured via reactive hyperemic response. Forearm blood flow (FBF, strain gauge plethysmography) was measured before and after 5 min of upper arm arterial occlusion. Blood pressure and lipid, insulin and glucose levels were measured. Pretreatment endothelial function was compared to 18 previously studied control children.
RESULTS: Percent fall in forearm vascular resistance was greater in controls (81.2 +/- 1.9%) than in children with GHD (69.6 +/- 5.3%, p = 0.021) but was not affected by GH (60.6 +/- 7.5%). GH markedly increased HOMAIR (21 +/- 7 versus 43 +/- 8, p = 0.004). Plasma lipid levels did not significantly differ.
CONCLUSION: These results indicate that endothelial function is impaired in children with GHD. GH therapy does not restore the impairment.
| Errataetall: |
CommentIn: J Pediatr Endocrinol Metab. 2008 Apr;21(4):319-21. - PMID 18556962 |
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| Medienart: |
Artikel |
| Erscheinungsjahr: |
2008 |
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| Erschienen: |
2008 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:21 |
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| Enthalten in: |
Journal of pediatric endocrinology & metabolism : JPEM - 21(2008), 4 vom: 03. Apr., Seite 323-8 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Hoffman, Robert P [VerfasserIn] |
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| Themen: |
12629-01-5 |
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| Anmerkungen: |
Date Completed 18.08.2008 Date Revised 07.09.2019 published: Print CommentIn: J Pediatr Endocrinol Metab. 2008 Apr;21(4):319-21. - PMID 18556962 Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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NLM180242989 |
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| 245 | 1 | 0 | |a Growth hormone (GH) treatment does not restore endothelial function in children with GH deficiency |
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| 500 | |a CommentIn: J Pediatr Endocrinol Metab. 2008 Apr;21(4):319-21. - PMID 18556962 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: In adults with growth hormone (GH) deficiency (GHD), GH treatment restores impaired endothelial function, a precursor of cardiovascular disease. Its effect in children with GHD is unknown | ||
| 520 | |a METHODS: Three months of GH (0.3 mg/kg/wk) were given to nine children with GHD. Endothelial function was measured via reactive hyperemic response. Forearm blood flow (FBF, strain gauge plethysmography) was measured before and after 5 min of upper arm arterial occlusion. Blood pressure and lipid, insulin and glucose levels were measured. Pretreatment endothelial function was compared to 18 previously studied control children | ||
| 520 | |a RESULTS: Percent fall in forearm vascular resistance was greater in controls (81.2 +/- 1.9%) than in children with GHD (69.6 +/- 5.3%, p = 0.021) but was not affected by GH (60.6 +/- 7.5%). GH markedly increased HOMAIR (21 +/- 7 versus 43 +/- 8, p = 0.004). Plasma lipid levels did not significantly differ | ||
| 520 | |a CONCLUSION: These results indicate that endothelial function is impaired in children with GHD. GH therapy does not restore the impairment | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
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| 650 | 7 | |a 12629-01-5 |2 NLM | |
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