Azoospermia after treatment with clomiphene citrate in patients with oligospermia
OBJECTIVE: To describe three cases of azoospermia in patients with oligospermia after clomiphene citrate (CC) intake.
DESIGN: Case report.
SETTING(S): Academic medical center.
PATIENT(S): Three patients with oligospermia.
INTERVENTION(S): Three oligospermic men used CC, resulting in azoospermia.
MAIN OUTCOME MEASURE(S): Semen analysis after CC use and after discontinuation of CC.
RESULT(S): Three patients were sent to our clinic for investigation of their azoospermia after use of CC. They had severe oligozoospermia (sperm concentrations of 3.4, 2.8, and 4.1 x 10(6)/mL, respectively) before treatment with CC. These patients were re-evaluated with two new semen analyses, showing azoospermia. After 3 months without use of the drug, the mean sperm concentration was 2.5 +/- 1.1 x 10(6)/mL.
CONCLUSION(S): The benefits of empiric treatment with CC must be balanced with the possible undesirable effects, such as azoospermia.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2008 |
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| Erschienen: |
2008 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:90 |
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| Enthalten in: |
Fertility and sterility - 90(2008), 5 vom: 01. Nov., Seite 2014.e11-2 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Pasqualotto, Fabio Firmbach [VerfasserIn] |
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| Links: |
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| Themen: |
1HRS458QU2 |
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| Anmerkungen: |
Date Completed 10.12.2008 Date Revised 21.11.2013 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.fertnstert.2008.03.036 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM180226487 |
|---|
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| 100 | 1 | |a Pasqualotto, Fabio Firmbach |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Azoospermia after treatment with clomiphene citrate in patients with oligospermia |
| 264 | 1 | |c 2008 | |
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| 500 | |a Date Completed 10.12.2008 | ||
| 500 | |a Date Revised 21.11.2013 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVE: To describe three cases of azoospermia in patients with oligospermia after clomiphene citrate (CC) intake | ||
| 520 | |a DESIGN: Case report | ||
| 520 | |a SETTING(S): Academic medical center | ||
| 520 | |a PATIENT(S): Three patients with oligospermia | ||
| 520 | |a INTERVENTION(S): Three oligospermic men used CC, resulting in azoospermia | ||
| 520 | |a MAIN OUTCOME MEASURE(S): Semen analysis after CC use and after discontinuation of CC | ||
| 520 | |a RESULT(S): Three patients were sent to our clinic for investigation of their azoospermia after use of CC. They had severe oligozoospermia (sperm concentrations of 3.4, 2.8, and 4.1 x 10(6)/mL, respectively) before treatment with CC. These patients were re-evaluated with two new semen analyses, showing azoospermia. After 3 months without use of the drug, the mean sperm concentration was 2.5 +/- 1.1 x 10(6)/mL | ||
| 520 | |a CONCLUSION(S): The benefits of empiric treatment with CC must be balanced with the possible undesirable effects, such as azoospermia | ||
| 650 | 4 | |a Case Reports | |
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| 700 | 1 | |a Pasqualotto, Eleonora Bedin |e verfasserin |4 aut | |
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