White matter abnormalities in subjects at ultra high-risk for schizophrenia and first-episode schizophrenic patients
Schizophrenia is associated with neuroanatomical abnormalities. Gray matter decrease seems to predate first schizophrenic episode. Whether white matter abnormalities predate the onset of psychotic symptoms is unclear. We investigated this issue using voxel-based morphometry (VBM) of structural magnetic resonance images to examine individuals with prodromal symptoms who were at ultra high-risk (UHR) of developing schizophrenia and compared them to first-episode schizophrenic patients and healthy controls. White matter volume maps from high-resolution magnetic resonance T1 weighted whole brain images were analyzed in a cross-sectional study using SPM2 in 30 UHR patients, 23 first-episode schizophrenic patients and 29 healthy controls. UHR patients showed significant lower white matter volume in the right superior temporal lobe compared to healthy controls. First-episode patients with schizophrenia showed widespread smaller white matter volume bilaterally compared to UHR patients. This study provides first evidence for smaller white matter volume in the right temporal lobe of UHR patients, one of the key structures in the pathophysiology of schizophrenia. Furthermore, white matter abnormalities seem to progress after transition into schizophrenia.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2008 |
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| Erschienen: |
2008 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:102 |
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| Enthalten in: |
Schizophrenia research - 102(2008), 1-3 vom: 29. Juli, Seite 141-9 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Witthaus, Henning [VerfasserIn] |
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| Links: |
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| Themen: |
Comparative Study |
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| Anmerkungen: |
Date Completed 30.09.2008 Date Revised 26.05.2016 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.schres.2008.03.022 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM179904191 |
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| 245 | 1 | 0 | |a White matter abnormalities in subjects at ultra high-risk for schizophrenia and first-episode schizophrenic patients |
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| 500 | |a Date Revised 26.05.2016 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Schizophrenia is associated with neuroanatomical abnormalities. Gray matter decrease seems to predate first schizophrenic episode. Whether white matter abnormalities predate the onset of psychotic symptoms is unclear. We investigated this issue using voxel-based morphometry (VBM) of structural magnetic resonance images to examine individuals with prodromal symptoms who were at ultra high-risk (UHR) of developing schizophrenia and compared them to first-episode schizophrenic patients and healthy controls. White matter volume maps from high-resolution magnetic resonance T1 weighted whole brain images were analyzed in a cross-sectional study using SPM2 in 30 UHR patients, 23 first-episode schizophrenic patients and 29 healthy controls. UHR patients showed significant lower white matter volume in the right superior temporal lobe compared to healthy controls. First-episode patients with schizophrenia showed widespread smaller white matter volume bilaterally compared to UHR patients. This study provides first evidence for smaller white matter volume in the right temporal lobe of UHR patients, one of the key structures in the pathophysiology of schizophrenia. Furthermore, white matter abnormalities seem to progress after transition into schizophrenia | ||
| 650 | 4 | |a Comparative Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 700 | 1 | |a Brüne, Martin |e verfasserin |4 aut | |
| 700 | 1 | |a Kaufmann, Christian |e verfasserin |4 aut | |
| 700 | 1 | |a Bohner, Georg |e verfasserin |4 aut | |
| 700 | 1 | |a Ozgürdal, Seza |e verfasserin |4 aut | |
| 700 | 1 | |a Gudlowski, Yehonala |e verfasserin |4 aut | |
| 700 | 1 | |a Heinz, Andreas |e verfasserin |4 aut | |
| 700 | 1 | |a Klingebiel, Randolf |e verfasserin |4 aut | |
| 700 | 1 | |a Juckel, Georg |e verfasserin |4 aut | |
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