WHO classification and WPSS predict posttransplantation outcome in patients with myelodysplastic syndrome : a study from the Gruppo Italiano Trapianto di Midollo Osseo (GITMO)
We evaluated the impact of World Health Organization (WHO) classification and WHO classification-based Prognostic Scoring System (WPSS) on the outcome of patients with myelodysplastic syndrome (MDS) who underwent allogeneic stem cell transplantation (allo-SCT) between 1990 and 2006. Five-year overall survival (OS) was 80% in refractory anemias, 57% in refractory cytopenias, 51% in refractory anemia with excess blasts 1 (RAEB-1), 28% in RAEB-2, and 25% in acute leukemia from MDS (P = .001). Five-year probability of relapse was 9%, 22%, 24%, 56%, and 53%, respectively (P < .001). Five-year transplant-related mortality (TRM) was 14%, 39%, 38%, 34%, and 44%, respectively (P = .24). In multivariate analysis, WHO classification showed a significant effect on OS (P = .017) and probability of relapse (P = .01); transfusion dependency was associated with a reduced OS (P = .01) and increased TRM (P = .037), whereas WPSS showed a prognostic significance on both OS (P = .001) and probability of relapse (P < .001). In patients without excess blasts, multilineage dysplasia and transfusion dependency affected OS (P = .001 and P = .009, respectively), and were associated with an increased TRM (P = .013 and P = .031, respectively). In these patients, WPSS identified 2 groups with different OS and TRM. These data suggest that WHO classification and WPSS have a relevant prognostic value in posttransplantation outcome of MDS patients.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2008 |
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| Erschienen: |
2008 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:112 |
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| Enthalten in: |
Blood - 112(2008), 3 vom: 01. Aug., Seite 895-902 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Alessandrino, Emilio Paolo [VerfasserIn] |
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| Links: |
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| Themen: |
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| Anmerkungen: |
Date Completed 05.09.2008 Date Revised 06.02.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1182/blood-2008-03-143735 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM179735063 |
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| 100 | 1 | |a Alessandrino, Emilio Paolo |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a WHO classification and WPSS predict posttransplantation outcome in patients with myelodysplastic syndrome |b a study from the Gruppo Italiano Trapianto di Midollo Osseo (GITMO) |
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| 500 | |a Date Completed 05.09.2008 | ||
| 500 | |a Date Revised 06.02.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a We evaluated the impact of World Health Organization (WHO) classification and WHO classification-based Prognostic Scoring System (WPSS) on the outcome of patients with myelodysplastic syndrome (MDS) who underwent allogeneic stem cell transplantation (allo-SCT) between 1990 and 2006. Five-year overall survival (OS) was 80% in refractory anemias, 57% in refractory cytopenias, 51% in refractory anemia with excess blasts 1 (RAEB-1), 28% in RAEB-2, and 25% in acute leukemia from MDS (P = .001). Five-year probability of relapse was 9%, 22%, 24%, 56%, and 53%, respectively (P < .001). Five-year transplant-related mortality (TRM) was 14%, 39%, 38%, 34%, and 44%, respectively (P = .24). In multivariate analysis, WHO classification showed a significant effect on OS (P = .017) and probability of relapse (P = .01); transfusion dependency was associated with a reduced OS (P = .01) and increased TRM (P = .037), whereas WPSS showed a prognostic significance on both OS (P = .001) and probability of relapse (P < .001). In patients without excess blasts, multilineage dysplasia and transfusion dependency affected OS (P = .001 and P = .009, respectively), and were associated with an increased TRM (P = .013 and P = .031, respectively). In these patients, WPSS identified 2 groups with different OS and TRM. These data suggest that WHO classification and WPSS have a relevant prognostic value in posttransplantation outcome of MDS patients | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 700 | 1 | |a Della Porta, Matteo Giovanni |e verfasserin |4 aut | |
| 700 | 1 | |a Bacigalupo, Andrea |e verfasserin |4 aut | |
| 700 | 1 | |a Van Lint, Maria Teresa |e verfasserin |4 aut | |
| 700 | 1 | |a Falda, Michele |e verfasserin |4 aut | |
| 700 | 1 | |a Onida, Francesco |e verfasserin |4 aut | |
| 700 | 1 | |a Bernardi, Massimo |e verfasserin |4 aut | |
| 700 | 1 | |a Iori, Anna Paola |e verfasserin |4 aut | |
| 700 | 1 | |a Rambaldi, Alessandro |e verfasserin |4 aut | |
| 700 | 1 | |a Cerretti, Raffaella |e verfasserin |4 aut | |
| 700 | 1 | |a Marenco, Paola |e verfasserin |4 aut | |
| 700 | 1 | |a Pioltelli, Pietro |e verfasserin |4 aut | |
| 700 | 1 | |a Malcovati, Luca |e verfasserin |4 aut | |
| 700 | 1 | |a Pascutto, Cristiana |e verfasserin |4 aut | |
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| 700 | 0 | |a Gruppo Italiano Trapianto di Midollo Osseo (GITMO) |e verfasserin |4 aut | |
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| 700 | 1 | |a Mordini, N |e investigator |4 oth | |
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| 700 | 1 | |a Van Lint, M T |e investigator |4 oth | |
| 700 | 1 | |a Corradini, P |e investigator |4 oth | |
| 700 | 1 | |a Milani, R |e investigator |4 oth | |
| 700 | 1 | |a Morra, E |e investigator |4 oth | |
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| 700 | 1 | |a Iannitto, E |e investigator |4 oth | |
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| 700 | 1 | |a Majolino, I |e investigator |4 oth | |
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