Gender differences in evidence-based pharmacological therapy for patients with stable coronary heart disease
BACKGROUND: Women have a higher morbidity and mortality than men after an acute coronary event. We analyzed the prescription rates of evidence-based pharmacological therapies for patients with stable coronary heart disease and whether there were any differences with respect to gender.
DESIGN: This cross-sectional study evaluated 8817 patients, 26.3% women, receiving attention from 1799 family doctors in primary care centers (PCC) throughout Spain, and who had had a coronary event requiring hospitalization in the previous 6 months to 10 years.
RESULTS: Mean age was 65.4 years and a mean time-lapse since hospitalization of 37.4 months. In the overall population, prescription medications were: antiplatelet drugs in 80.5% of patients, 79% statins, 66% blockers of the angiotensin-renin system (BARS) and 47% beta-blockers. Males received less cardiovascular disease medications than females (4.3+/-1.5 versus 4.6+/-1.6, respectively; p<0.001), but when adjusted for risk factors the significance was lost (p=0.231). Following adjustment for risk factors and for co-morbidities, the use of diuretics was significantly higher in women while beta-blockers and statins were higher in men. The triple combination of antithrombotics, beta-blockers and statins was used in 41.4% (43.8% males versus 34.6% females; p<0.001) while 24.3% used this triple combination plus a BARS; without significant difference between the genders.
CONCLUSIONS: An important percentage of patients with stable coronary disease, particularly women, attended-to in primary care do not receive medications that have been shown to decrease the morbido-mortality of cardiovascular disease.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2009 |
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| Erschienen: |
2009 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:133 |
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| Enthalten in: |
International journal of cardiology - 133(2009), 3 vom: 17. Apr., Seite 336-40 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Lahoz, Carlos [VerfasserIn] |
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| Links: |
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| Themen: |
Cardiovascular Agents |
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| Anmerkungen: |
Date Completed 11.01.2010 Date Revised 06.04.2009 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.ijcard.2007.12.115 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM179629646 |
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| 100 | 1 | |a Lahoz, Carlos |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Gender differences in evidence-based pharmacological therapy for patients with stable coronary heart disease |
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| 500 | |a Date Revised 06.04.2009 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: Women have a higher morbidity and mortality than men after an acute coronary event. We analyzed the prescription rates of evidence-based pharmacological therapies for patients with stable coronary heart disease and whether there were any differences with respect to gender | ||
| 520 | |a DESIGN: This cross-sectional study evaluated 8817 patients, 26.3% women, receiving attention from 1799 family doctors in primary care centers (PCC) throughout Spain, and who had had a coronary event requiring hospitalization in the previous 6 months to 10 years | ||
| 520 | |a RESULTS: Mean age was 65.4 years and a mean time-lapse since hospitalization of 37.4 months. In the overall population, prescription medications were: antiplatelet drugs in 80.5% of patients, 79% statins, 66% blockers of the angiotensin-renin system (BARS) and 47% beta-blockers. Males received less cardiovascular disease medications than females (4.3+/-1.5 versus 4.6+/-1.6, respectively; p<0.001), but when adjusted for risk factors the significance was lost (p=0.231). Following adjustment for risk factors and for co-morbidities, the use of diuretics was significantly higher in women while beta-blockers and statins were higher in men. The triple combination of antithrombotics, beta-blockers and statins was used in 41.4% (43.8% males versus 34.6% females; p<0.001) while 24.3% used this triple combination plus a BARS; without significant difference between the genders | ||
| 520 | |a CONCLUSIONS: An important percentage of patients with stable coronary disease, particularly women, attended-to in primary care do not receive medications that have been shown to decrease the morbido-mortality of cardiovascular disease | ||
| 650 | 4 | |a Comparative Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Cardiovascular Agents |2 NLM | |
| 700 | 1 | |a Mantilla, Teresa |e verfasserin |4 aut | |
| 700 | 1 | |a Taboada, Manuel |e verfasserin |4 aut | |
| 700 | 1 | |a Soler, Begoña |e verfasserin |4 aut | |
| 700 | 1 | |a Tranche, Salvador |e verfasserin |4 aut | |
| 700 | 1 | |a López-Rodriguez, Isidro |e verfasserin |4 aut | |
| 700 | 1 | |a Monteiro, Beatriz |e verfasserin |4 aut | |
| 700 | 1 | |a Martin-Jadraque, Raquel |e verfasserin |4 aut | |
| 700 | 1 | |a Sanchez-Zamorano, Miguel A |e verfasserin |4 aut | |
| 700 | 1 | |a Mostaza, Jose M |e verfasserin |4 aut | |
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