Gut microflora is a key player in host energy homeostasis
Gut microflora is now considered as a key organ involved in host energy homeostasis. Recent data suggest that the alterations of the gut bacteria ecosystem could contribute to the development of metabolic disorders such as type 2 diabetes and obesity. First, gut microflora may increase energy efficiency of non digested food via the fermentation, thus providing more energy to the host. Secondly, fatty acids flux and storage in the adipose tissue is under the control of the fasting-induced adipocyte factor FIAF, which expression depends on gut microflora. Third, high-fat diet feeding changes gut bacteria profile, leading to a drop in bifidobacteria content, which correlates with a higher LPS plasma levels, thereby participating to the onset of inflammation, insulin resistance and type 2 diabetes associated with obesity. Changing gut microflora composition could be a useful tool to prevent or to treat high-fat/low fibres diet-induced metabolic syndrome. double dagger.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2008 |
|---|---|
| Erschienen: |
2008 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:24 |
|---|---|
| Enthalten in: |
Medecine sciences : M/S - 24(2008), 5 vom: 05. Mai, Seite 505-10 |
| Sprache: |
Französisch |
|---|
| Weiterer Titel: |
Implication de la flore intestinale dans le métabolisme énergétique |
|---|
| Beteiligte Personen: |
Delzenne, Nathalie M [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
|---|
| Anmerkungen: |
Date Completed 26.08.2008 Date Revised 09.05.2008 published: Print Citation Status MEDLINE |
|---|
| doi: |
10.1051/medsci/2008245505 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM179443267 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM179443267 | ||
| 003 | DE-627 | ||
| 005 | 20231223153806.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231223s2008 xx |||||o 00| ||fre c | ||
| 024 | 7 | |a 10.1051/medsci/2008245505 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n0598.xml |
| 035 | |a (DE-627)NLM179443267 | ||
| 035 | |a (NLM)18466728 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a fre | ||
| 100 | 1 | |a Delzenne, Nathalie M |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Gut microflora is a key player in host energy homeostasis |
| 246 | 3 | 3 | |a Implication de la flore intestinale dans le métabolisme énergétique |
| 264 | 1 | |c 2008 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 26.08.2008 | ||
| 500 | |a Date Revised 09.05.2008 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Gut microflora is now considered as a key organ involved in host energy homeostasis. Recent data suggest that the alterations of the gut bacteria ecosystem could contribute to the development of metabolic disorders such as type 2 diabetes and obesity. First, gut microflora may increase energy efficiency of non digested food via the fermentation, thus providing more energy to the host. Secondly, fatty acids flux and storage in the adipose tissue is under the control of the fasting-induced adipocyte factor FIAF, which expression depends on gut microflora. Third, high-fat diet feeding changes gut bacteria profile, leading to a drop in bifidobacteria content, which correlates with a higher LPS plasma levels, thereby participating to the onset of inflammation, insulin resistance and type 2 diabetes associated with obesity. Changing gut microflora composition could be a useful tool to prevent or to treat high-fat/low fibres diet-induced metabolic syndrome. double dagger | ||
| 650 | 4 | |a English Abstract | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 700 | 1 | |a Cani, Patrice D |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Medecine sciences : M/S |d 1996 |g 24(2008), 5 vom: 05. Mai, Seite 505-10 |w (DE-627)NLM08683102X |x 1958-5381 |7 nnns |
| 773 | 1 | 8 | |g volume:24 |g year:2008 |g number:5 |g day:05 |g month:05 |g pages:505-10 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1051/medsci/2008245505 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 24 |j 2008 |e 5 |b 05 |c 05 |h 505-10 | ||