Novel 3-carboxamide-coumarins as potent and selective FXIIa inhibitors
Recently, FXIIa was highlighted as an original attractive target for the development of new anticoagulant drugs with low rates of therapy-related hemorrhages. In this work, we describe the development of a new series of 3-carboxamide-coumarins that are the first potent and selective nonpeptidic inhibitors of FXIIa.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2008 |
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| Erschienen: |
2008 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:51 |
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| Enthalten in: |
Journal of medicinal chemistry - 51(2008), 11 vom: 12. Juni, Seite 3077-80 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Robert, Séverine [VerfasserIn] |
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| Links: |
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| Themen: |
Amides |
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| Anmerkungen: |
Date Completed 28.07.2008 Date Revised 05.06.2008 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1021/jm8002697 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM179377957 |
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| 520 | |a Recently, FXIIa was highlighted as an original attractive target for the development of new anticoagulant drugs with low rates of therapy-related hemorrhages. In this work, we describe the development of a new series of 3-carboxamide-coumarins that are the first potent and selective nonpeptidic inhibitors of FXIIa | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 7 | |a Amides |2 NLM | |
| 650 | 7 | |a Anticoagulants |2 NLM | |
| 650 | 7 | |a Coumarins |2 NLM | |
| 650 | 7 | |a Factor XIIa |2 NLM | |
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| 700 | 1 | |a Bertolla, Carine |e verfasserin |4 aut | |
| 700 | 1 | |a Masereel, Bernard |e verfasserin |4 aut | |
| 700 | 1 | |a Dogné, Jean-Michel |e verfasserin |4 aut | |
| 700 | 1 | |a Pochet, Lionel |e verfasserin |4 aut | |
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