Serious intoxication with hydroxychloroquine, with haemodynamic instability : a case report supporting treatment with diazepam
A 37-year-old woman was admitted to the emergency room because of an autointoxication with hydroxychloroquine, leading to haemodynamic instability. Treatment consisted of the rapid administration of intravenous diazepam, after which the hypotension recovered rapidly even though no vasoactive medication was given. Treatment with diazepam has been advised in the Netherlands for many years in case of severe hydroxychloroquine intoxication, despite the fact that convincing evidence for its use is lacking. On the basis of the experience with the relevant cases, the administration of diazepam, 2 mg/kg initially followed by 2 mg/kg/24 hours as a continuous infusion, should certainly be considered for supportive treatment in the ICU in case of severe haemodynamic instability.
| Medienart: |
Artikel |
|---|
| Erscheinungsjahr: |
2008 |
|---|---|
| Erschienen: |
2008 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:152 |
|---|---|
| Enthalten in: |
Nederlands tijdschrift voor geneeskunde - 152(2008), 9 vom: 01. März, Seite 509-12 |
| Sprache: |
Niederländisch |
|---|
| Weiterer Titel: |
Ernstige intoxicatie met hydroxychloroquine, met hemodynamische instabiliteit: casuistische ondersteuning voor behandeling met diazepam |
|---|
| Beteiligte Personen: |
Olgers, T J [VerfasserIn] |
|---|
| Themen: |
4QWG6N8QKH |
|---|
| Anmerkungen: |
Date Completed 28.04.2008 Date Revised 21.11.2013 published: Print Citation Status MEDLINE |
|---|
| Förderinstitution / Projekttitel: |
|
|---|
| PPN (Katalog-ID): |
NLM17871304X |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM17871304X | ||
| 003 | DE-627 | ||
| 005 | 20231223152550.0 | ||
| 007 | tu | ||
| 008 | 231223s2008 xx ||||| 00| ||dut c | ||
| 028 | 5 | 2 | |a pubmed24n0596.xml |
| 035 | |a (DE-627)NLM17871304X | ||
| 035 | |a (NLM)18389886 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a dut | ||
| 100 | 1 | |a Olgers, T J |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Serious intoxication with hydroxychloroquine, with haemodynamic instability |b a case report supporting treatment with diazepam |
| 246 | 3 | 3 | |a Ernstige intoxicatie met hydroxychloroquine, met hemodynamische instabiliteit: casuistische ondersteuning voor behandeling met diazepam |
| 264 | 1 | |c 2008 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a Date Completed 28.04.2008 | ||
| 500 | |a Date Revised 21.11.2013 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a A 37-year-old woman was admitted to the emergency room because of an autointoxication with hydroxychloroquine, leading to haemodynamic instability. Treatment consisted of the rapid administration of intravenous diazepam, after which the hypotension recovered rapidly even though no vasoactive medication was given. Treatment with diazepam has been advised in the Netherlands for many years in case of severe hydroxychloroquine intoxication, despite the fact that convincing evidence for its use is lacking. On the basis of the experience with the relevant cases, the administration of diazepam, 2 mg/kg initially followed by 2 mg/kg/24 hours as a continuous infusion, should certainly be considered for supportive treatment in the ICU in case of severe haemodynamic instability | ||
| 650 | 4 | |a Case Reports | |
| 650 | 4 | |a English Abstract | |
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Hydroxychloroquine |2 NLM | |
| 650 | 7 | |a 4QWG6N8QKH |2 NLM | |
| 650 | 7 | |a Diazepam |2 NLM | |
| 650 | 7 | |a Q3JTX2Q7TU |2 NLM | |
| 700 | 1 | |a Tulleken, J E |e verfasserin |4 aut | |
| 700 | 1 | |a Monteban-Kooistra, W E |e verfasserin |4 aut | |
| 700 | 1 | |a Ligtenberg, J J M |e verfasserin |4 aut | |
| 700 | 1 | |a Meertens, J H |e verfasserin |4 aut | |
| 700 | 1 | |a Zijlstra, J G |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Nederlands tijdschrift voor geneeskunde |d 1946 |g 152(2008), 9 vom: 01. März, Seite 509-12 |w (DE-627)NLM000034231 |x 1876-8784 |7 nnns |
| 773 | 1 | 8 | |g volume:152 |g year:2008 |g number:9 |g day:01 |g month:03 |g pages:509-12 |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 152 |j 2008 |e 9 |b 01 |c 03 |h 509-12 | ||