Differential expression of duplicated genes for prothymosin alpha during zebrafish development
(c) 2008 Wiley-Liss, Inc..
We show that ptma, a single copy gene found in all organisms investigated so far, is duplicated in zebrafish. The two genes, ptmaa and ptmab, are individually controlled as indicated by their different expression patterns during embryonic development. Only the ptmab transcript is observed at 4 and 8 hpf of development in all embryonic cells, whereas both genes are expressed at later stages as revealed by in situ hybridization studies. In most cases, the two genes are expressed in the same territories, but only the ptmaa transcript was found in the trigeminal ganglion and in endodermal pouches. In the eye, at 72 hpf, the ptmaa and ptmab transcripts were found in amacrine cells, whereas only the ptmab transcript appeared in horizontal cells. The existence of two prothymosin genes indicates that their function in cell proliferation and differentiation is more complex in fishes than in mammals.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2008 |
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| Erschienen: |
2008 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:237 |
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| Enthalten in: |
Developmental dynamics : an official publication of the American Association of Anatomists - 237(2008), 4 vom: 01. Apr., Seite 1112-8 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Donizetti, Aldo [VerfasserIn] |
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| Links: |
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| Themen: |
61512-21-8 |
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| Anmerkungen: |
Date Completed 25.08.2008 Date Revised 02.04.2008 published: Print Citation Status MEDLINE |
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| doi: |
10.1002/dvdy.21492 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM178350087 |
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| 245 | 1 | 0 | |a Differential expression of duplicated genes for prothymosin alpha during zebrafish development |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a (c) 2008 Wiley-Liss, Inc. | ||
| 520 | |a We show that ptma, a single copy gene found in all organisms investigated so far, is duplicated in zebrafish. The two genes, ptmaa and ptmab, are individually controlled as indicated by their different expression patterns during embryonic development. Only the ptmab transcript is observed at 4 and 8 hpf of development in all embryonic cells, whereas both genes are expressed at later stages as revealed by in situ hybridization studies. In most cases, the two genes are expressed in the same territories, but only the ptmaa transcript was found in the trigeminal ganglion and in endodermal pouches. In the eye, at 72 hpf, the ptmaa and ptmab transcripts were found in amacrine cells, whereas only the ptmab transcript appeared in horizontal cells. The existence of two prothymosin genes indicates that their function in cell proliferation and differentiation is more complex in fishes than in mammals | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Protein Isoforms |2 NLM | |
| 650 | 7 | |a Protein Precursors |2 NLM | |
| 650 | 7 | |a Zebrafish Proteins |2 NLM | |
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| 650 | 7 | |a Thymosin |2 NLM | |
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| 700 | 1 | |a Liccardo, Daniela |e verfasserin |4 aut | |
| 700 | 1 | |a Esposito, Daniela |e verfasserin |4 aut | |
| 700 | 1 | |a Del Gaudio, Rosanna |e verfasserin |4 aut | |
| 700 | 1 | |a Locascio, Annamaria |e verfasserin |4 aut | |
| 700 | 1 | |a Ferrara, Diana |e verfasserin |4 aut | |
| 700 | 1 | |a Minucci, Sergio |e verfasserin |4 aut | |
| 700 | 1 | |a Aniello, Francesco |e verfasserin |4 aut | |
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