Patients' characteristics and clinical implications of suboptimal CD4 T-cell gains after 1 year of successful antiretroviral therapy
To describe characteristics and prognosis of patients with suboptimal immunological response to combined antiretroviral therapy (CART). Using data from a multicenter cohort study, we selected patients who initiated CART and showed suboptimal CD4-T cell response (defined as <50 cells/L increase) after 1 year of therapy, despite sustained virological suppression. Characteristics of those patients were compared with subjects who showed optimal immunological response. Of 650 patients with virological suppression, 108 (16.6%) showed suboptimal CD4-T cell response. Independent predictors of suboptimal response were previous injection drug use (OR, 1.85; 95% CI, 1.12-2.98) and age at CART initiation (OR, 1.04 per year increase; 95%CI, 1.01-1.06). Hepatitis C virus coinfection was not associated with impaired immunological response. As compared with patients with optimal immunological response, those with suboptimal response had a higher mortality rate (3.22 versus 0.71 per 100 person-years; p=.001), but a similar rate of new AIDS-defining events. In patients with sustained virological suppression with CART, previous injection drug use, but not hepatitis C virus coinfection, and older age at initiation of therapy were associated with suboptimal CD4 T-cell responses. Patients with suboptimal response had a higher mortality over time, mainly due to diseases other than AIDS-defining events.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2008 |
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| Erschienen: |
2008 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:6 |
|---|---|
| Enthalten in: |
Current HIV research - 6(2008), 2 vom: 11. März, Seite 100-7 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Gutiérrez, Félix [VerfasserIn] |
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| Themen: |
Anti-HIV Agents |
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| Anmerkungen: |
Date Completed 31.03.2008 Date Revised 08.04.2022 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM178203351 |
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| 100 | 1 | |a Gutiérrez, Félix |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Patients' characteristics and clinical implications of suboptimal CD4 T-cell gains after 1 year of successful antiretroviral therapy |
| 264 | 1 | |c 2008 | |
| 336 | |a Text |b txt |2 rdacontent | ||
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| 500 | |a Date Completed 31.03.2008 | ||
| 500 | |a Date Revised 08.04.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a To describe characteristics and prognosis of patients with suboptimal immunological response to combined antiretroviral therapy (CART). Using data from a multicenter cohort study, we selected patients who initiated CART and showed suboptimal CD4-T cell response (defined as <50 cells/L increase) after 1 year of therapy, despite sustained virological suppression. Characteristics of those patients were compared with subjects who showed optimal immunological response. Of 650 patients with virological suppression, 108 (16.6%) showed suboptimal CD4-T cell response. Independent predictors of suboptimal response were previous injection drug use (OR, 1.85; 95% CI, 1.12-2.98) and age at CART initiation (OR, 1.04 per year increase; 95%CI, 1.01-1.06). Hepatitis C virus coinfection was not associated with impaired immunological response. As compared with patients with optimal immunological response, those with suboptimal response had a higher mortality rate (3.22 versus 0.71 per 100 person-years; p=.001), but a similar rate of new AIDS-defining events. In patients with sustained virological suppression with CART, previous injection drug use, but not hepatitis C virus coinfection, and older age at initiation of therapy were associated with suboptimal CD4 T-cell responses. Patients with suboptimal response had a higher mortality over time, mainly due to diseases other than AIDS-defining events | ||
| 650 | 4 | |a Comparative Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Anti-HIV Agents |2 NLM | |
| 700 | 1 | |a Padilla, Sergio |e verfasserin |4 aut | |
| 700 | 1 | |a Masiá, Mar |e verfasserin |4 aut | |
| 700 | 1 | |a Iribarren, José A |e verfasserin |4 aut | |
| 700 | 1 | |a Moreno, Santiago |e verfasserin |4 aut | |
| 700 | 1 | |a Viciana, Pompeyo |e verfasserin |4 aut | |
| 700 | 1 | |a Hernández-Quero, José |e verfasserin |4 aut | |
| 700 | 1 | |a Alemán, Remedios |e verfasserin |4 aut | |
| 700 | 1 | |a Vidal, Francesc |e verfasserin |4 aut | |
| 700 | 1 | |a Salavert, Miguel |e verfasserin |4 aut | |
| 700 | 1 | |a Blanco, José R |e verfasserin |4 aut | |
| 700 | 1 | |a Leal, Manuel |e verfasserin |4 aut | |
| 700 | 1 | |a Dronda, Fernando |e verfasserin |4 aut | |
| 700 | 1 | |a Perez Hoyos, Santiago |e verfasserin |4 aut | |
| 700 | 1 | |a del Amo, Julia |e verfasserin |4 aut | |
| 700 | 0 | |a CoRIS-MD |e verfasserin |4 aut | |
| 700 | 1 | |a Berenguer, Juan |e investigator |4 oth | |
| 700 | 1 | |a García, Federico |e investigator |4 oth | |
| 700 | 1 | |a Labarga, Pablo |e investigator |4 oth | |
| 700 | 1 | |a Angeles Muñoz, Maria |e investigator |4 oth | |
| 700 | 1 | |a Arrizabalaga, J |e investigator |4 oth | |
| 700 | 1 | |a Aramburu, M J |e investigator |4 oth | |
| 700 | 1 | |a Camino, X |e investigator |4 oth | |
| 700 | 1 | |a Rodríguez-Arrondo, F |e investigator |4 oth | |
| 700 | 1 | |a von Wichmann, M A |e investigator |4 oth | |
| 700 | 1 | |a Pérez-Elías, María Jesús |e investigator |4 oth | |
| 700 | 1 | |a Casado Osorio, Jose Luis |e investigator |4 oth | |
| 700 | 1 | |a Moreno Zamora, Ana |e investigator |4 oth | |
| 700 | 1 | |a Dronda, Fernando |e investigator |4 oth | |
| 700 | 1 | |a Lopez-Cortés, Luis Fernando |e investigator |4 oth | |
| 700 | 1 | |a Trastoy González, Mónica |e investigator |4 oth | |
| 700 | 1 | |a Alcazar-Caballero, Rosario Mata |e investigator |4 oth | |
| 700 | 1 | |a García, Federico |e investigator |4 oth | |
| 700 | 1 | |a Muñoz, Leopoldo |e investigator |4 oth | |
| 700 | 1 | |a Parra, Jorge |e investigator |4 oth | |
| 700 | 1 | |a Pena, Alejandro |e investigator |4 oth | |
| 700 | 1 | |a Hernández Quero, José |e investigator |4 oth | |
| 700 | 1 | |a Gómez Sirvent, Juan Luis |e investigator |4 oth | |
| 700 | 1 | |a Alonso Socas, Ma del Mar |e investigator |4 oth | |
| 700 | 1 | |a Hernández Calzadil, Carlos |e investigator |4 oth | |
| 700 | 1 | |a López Lirola, Ana María |e investigator |4 oth | |
| 700 | 1 | |a Peraire, Joaquim |e investigator |4 oth | |
| 700 | 1 | |a Viladés, Consuelo |e investigator |4 oth | |
| 700 | 1 | |a Veloso, Sergi |e investigator |4 oth | |
| 700 | 1 | |a Richart, Cristóbal |e investigator |4 oth | |
| 700 | 1 | |a Lacruz, José |e investigator |4 oth | |
| 700 | 1 | |a Falcó Couchoud, Cristina |e investigator |4 oth | |
| 700 | 1 | |a Blanes Juliá, Marino |e investigator |4 oth | |
| 700 | 1 | |a Navarro Ibáñez, Vicente |e investigator |4 oth | |
| 700 | 1 | |a Salavert Lletí, Miguel |e investigator |4 oth | |
| 700 | 1 | |a Bernal, Enrique |e investigator |4 oth | |
| 700 | 1 | |a Ramos, José Manuel |e investigator |4 oth | |
| 700 | 1 | |a Escolano, Clara |e investigator |4 oth | |
| 700 | 1 | |a Blanco, José Ramón |e investigator |4 oth | |
| 700 | 1 | |a Ibarra, Valvanera |e investigator |4 oth | |
| 700 | 1 | |a Oteo, José Antonio |e investigator |4 oth | |
| 700 | 1 | |a Asensio, Román |e investigator |4 oth | |
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