Chloroquine-resistance molecular markers (Pfcrt T76 and Pfmdr-1 Y86) and amodiaquine resistance in Burkina Faso
We investigated the relationship between the two main molecular markers for chloroquine resistance (Pfcrt T76 and Pfmdr-1 Y86) and the clinical efficacy of amodiaquine in Burkina Faso. Before treatment, the prevalence of Pfcrt T76, Pfmdr-1 Y86 or both mutations in the same infection was significantly higher in patients who experienced a recrudescence than in those who successfully responded to the treatment. Therefore, these two molecular markers could be useful in monitoring amodiaquine resistance, particularly in countries where this drug is used in combination with artesunate as first- or second-line treatment.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2008 |
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| Erschienen: |
2008 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:13 |
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| Enthalten in: |
Tropical medicine & international health : TM & IH - 13(2008), 2 vom: 01. Feb., Seite 238-40 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Tinto, Halidou [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 17.03.2008 Date Revised 21.11.2013 published: Print Citation Status MEDLINE |
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| doi: |
10.1111/j.1365-3156.2007.01995.x |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM177898844 |
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| 100 | 1 | |a Tinto, Halidou |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Chloroquine-resistance molecular markers (Pfcrt T76 and Pfmdr-1 Y86) and amodiaquine resistance in Burkina Faso |
| 264 | 1 | |c 2008 | |
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| 500 | |a Date Completed 17.03.2008 | ||
| 500 | |a Date Revised 21.11.2013 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a We investigated the relationship between the two main molecular markers for chloroquine resistance (Pfcrt T76 and Pfmdr-1 Y86) and the clinical efficacy of amodiaquine in Burkina Faso. Before treatment, the prevalence of Pfcrt T76, Pfmdr-1 Y86 or both mutations in the same infection was significantly higher in patients who experienced a recrudescence than in those who successfully responded to the treatment. Therefore, these two molecular markers could be useful in monitoring amodiaquine resistance, particularly in countries where this drug is used in combination with artesunate as first- or second-line treatment | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Antimalarials |2 NLM | |
| 650 | 7 | |a Mdr1 protein, Plasmodium falciparum |2 NLM | |
| 650 | 7 | |a Membrane Transport Proteins |2 NLM | |
| 650 | 7 | |a Multidrug Resistance-Associated Proteins |2 NLM | |
| 650 | 7 | |a PfCRT protein, Plasmodium falciparum |2 NLM | |
| 650 | 7 | |a Protozoan Proteins |2 NLM | |
| 650 | 7 | |a Amodiaquine |2 NLM | |
| 650 | 7 | |a 220236ED28 |2 NLM | |
| 650 | 7 | |a Chloroquine |2 NLM | |
| 650 | 7 | |a 886U3H6UFF |2 NLM | |
| 700 | 1 | |a Guekoun, Lougué |e verfasserin |4 aut | |
| 700 | 1 | |a Zongo, Issaka |e verfasserin |4 aut | |
| 700 | 1 | |a Guiguemdé, Robert Tinga |e verfasserin |4 aut | |
| 700 | 1 | |a D'Alessandro, Umberto |e verfasserin |4 aut | |
| 700 | 1 | |a Ouédraogo, Jean Bosco |e verfasserin |4 aut | |
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