Ocular toxicity due to 4-aminoquinoline derivatives
Retinal toxicity of chloroquine has been extensively studied since its first description in 1957. This drug is used on a chronic basis to treat several rheumatologic and dermatologic diseases, a there is a trend to use hydroxychloroquine rather than chloroquine. The recommended dose for hydroxychloroquine is 4 mg/kg lean body weight per day. The clinical picture of chloroquine retinopathy is characterized by a paracentral visual field scotoma with associated parafoveal retinal pigment epithelium atrophy, known as 'bull's eye maculopathy. The visual field and Amsler grids are the exams that early detect toxicity retinopathy. The authors aim to review the pathogenesis, clinical features, differential diagnosis, complementary exams, and treatment. The sources of references were PubMed (MEDLINE), LILACS and Ophthalmology Library databases.
| Medienart: |
Artikel |
|---|
| Erscheinungsjahr: |
2007 |
|---|---|
| Erschienen: |
2007 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:70 |
|---|---|
| Enthalten in: |
Arquivos brasileiros de oftalmologia - 70(2007), 6 vom: 23. Nov., Seite 1046-51 |
| Sprache: |
Portugiesisch |
|---|
| Weiterer Titel: |
Toxicidade ocular por derivados da 4-aminoquinolona |
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| Beteiligte Personen: |
Gouveia, Enéias Bezerra [VerfasserIn] |
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| Themen: |
4-aminoquinoline |
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| Anmerkungen: |
Date Completed 18.08.2008 Date Revised 23.09.2019 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM177246642 |
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| 245 | 1 | 0 | |a Ocular toxicity due to 4-aminoquinoline derivatives |
| 246 | 3 | 3 | |a Toxicidade ocular por derivados da 4-aminoquinolona |
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| 500 | |a Date Completed 18.08.2008 | ||
| 500 | |a Date Revised 23.09.2019 | ||
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Retinal toxicity of chloroquine has been extensively studied since its first description in 1957. This drug is used on a chronic basis to treat several rheumatologic and dermatologic diseases, a there is a trend to use hydroxychloroquine rather than chloroquine. The recommended dose for hydroxychloroquine is 4 mg/kg lean body weight per day. The clinical picture of chloroquine retinopathy is characterized by a paracentral visual field scotoma with associated parafoveal retinal pigment epithelium atrophy, known as 'bull's eye maculopathy. The visual field and Amsler grids are the exams that early detect toxicity retinopathy. The authors aim to review the pathogenesis, clinical features, differential diagnosis, complementary exams, and treatment. The sources of references were PubMed (MEDLINE), LILACS and Ophthalmology Library databases | ||
| 650 | 4 | |a English Abstract | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 7 | |a Aminoquinolines |2 NLM | |
| 650 | 7 | |a Antimalarials |2 NLM | |
| 650 | 7 | |a Hydroxychloroquine |2 NLM | |
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| 700 | 1 | |a Lourenzi, Valeria Pinheiro M |e verfasserin |4 aut | |
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