The molecular epidemiology of hepatitis A in The Netherlands; the usefulness of typing isolated viral strains
OBJECTIVE: To investigate the epidemiological links between several outbreaks of hepatitis A in The Netherlands (2001-2004).
DESIGN: Descriptive.
METHOD: Blood samples taken in connection with reports of hepatitis A to municipal health centres from 2001-2004, were typed by determining the nucleotide sequence of the VP3-VP1 and the VP1-P2A regions of the genome of the hepatitis A virus (HAV). Genetic distances were represented graphically by means of a phylogenetic tree.
RESULTS: The study into the spread of various subtypes of HAV showed a clear link between the HAV-(sub)genotype and risk of transmission: in men that have sex with men only genotype 1A occurred, in travellers to African countries genotype 1B was predominantly seen.
CONCLUSION: A database containing various viral strains from people with hepatitis A in The Netherlands could, if kept up to date, be used as an aid in confirming the classical way of tracing sources as well as for the evaluation of preventative measures.
| Errataetall: |
CommentIn: Ned Tijdschr Geneeskd. 2008 Feb 16;152(7):408. - PMID 18380392 |
|---|---|
| Medienart: |
Artikel |
| Erscheinungsjahr: |
2007 |
|---|---|
| Erschienen: |
2007 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:151 |
|---|---|
| Enthalten in: |
Nederlands tijdschrift voor geneeskunde - 151(2007), 50 vom: 15. Dez., Seite 2779-86 |
| Sprache: |
Niederländisch |
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| Weiterer Titel: |
Moleculaire epidemiologie van hepatitis A in Nederland; het nut van het typeren van geïsoleerde virusstammen |
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| Beteiligte Personen: |
Bruisten, S M [VerfasserIn] |
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| Themen: |
English Abstract |
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| Anmerkungen: |
Date Completed 20.02.2008 Date Revised 19.11.2009 published: Print CommentIn: Ned Tijdschr Geneeskd. 2008 Feb 16;152(7):408. - PMID 18380392 Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM177211105 |
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| 100 | 1 | |a Bruisten, S M |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The molecular epidemiology of hepatitis A in The Netherlands; the usefulness of typing isolated viral strains |
| 246 | 3 | 3 | |a Moleculaire epidemiologie van hepatitis A in Nederland; het nut van het typeren van geïsoleerde virusstammen |
| 264 | 1 | |c 2007 | |
| 336 | |a Text |b txt |2 rdacontent | ||
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| 500 | |a Date Completed 20.02.2008 | ||
| 500 | |a Date Revised 19.11.2009 | ||
| 500 | |a published: Print | ||
| 500 | |a CommentIn: Ned Tijdschr Geneeskd. 2008 Feb 16;152(7):408. - PMID 18380392 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVE: To investigate the epidemiological links between several outbreaks of hepatitis A in The Netherlands (2001-2004) | ||
| 520 | |a DESIGN: Descriptive | ||
| 520 | |a METHOD: Blood samples taken in connection with reports of hepatitis A to municipal health centres from 2001-2004, were typed by determining the nucleotide sequence of the VP3-VP1 and the VP1-P2A regions of the genome of the hepatitis A virus (HAV). Genetic distances were represented graphically by means of a phylogenetic tree | ||
| 520 | |a RESULTS: The study into the spread of various subtypes of HAV showed a clear link between the HAV-(sub)genotype and risk of transmission: in men that have sex with men only genotype 1A occurred, in travellers to African countries genotype 1B was predominantly seen | ||
| 520 | |a CONCLUSION: A database containing various viral strains from people with hepatitis A in The Netherlands could, if kept up to date, be used as an aid in confirming the classical way of tracing sources as well as for the evaluation of preventative measures | ||
| 650 | 4 | |a English Abstract | |
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a RNA, Viral |2 NLM | |
| 650 | 7 | |a Viral Structural Proteins |2 NLM | |
| 700 | 1 | |a Tjon, G M S |e verfasserin |4 aut | |
| 700 | 1 | |a van den Hoek, J A R |e verfasserin |4 aut | |
| 700 | 1 | |a Wijkmans, C J |e verfasserin |4 aut | |
| 700 | 1 | |a Götz, H M |e verfasserin |4 aut | |
| 700 | 1 | |a Coutinho, R A |e verfasserin |4 aut | |
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