Structural genomics of protein phosphatases
The New York SGX Research Center for Structural Genomics (NYSGXRC) of the NIGMS Protein Structure Initiative (PSI) has applied its high-throughput X-ray crystallographic structure determination platform to systematic studies of all human protein phosphatases and protein phosphatases from biomedically-relevant pathogens. To date, the NYSGXRC has determined structures of 21 distinct protein phosphatases: 14 from human, 2 from mouse, 2 from the pathogen Toxoplasma gondii, 1 from Trypanosoma brucei, the parasite responsible for African sleeping sickness, and 2 from the principal mosquito vector of malaria in Africa, Anopheles gambiae. These structures provide insights into both normal and pathophysiologic processes, including transcriptional regulation, regulation of major signaling pathways, neural development, and type 1 diabetes. In conjunction with the contributions of other international structural genomics consortia, these efforts promise to provide an unprecedented database and materials repository for structure-guided experimental and computational discovery of inhibitors for all classes of protein phosphatases.
Medienart: |
Artikel |
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Erscheinungsjahr: |
2007 |
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Erschienen: |
2007 |
Enthalten in: |
Zur Gesamtaufnahme - volume:8 |
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Enthalten in: |
Journal of structural and functional genomics - 8(2007), 2-3 vom: 15. Sept., Seite 121-40 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Almo, Steven C [VerfasserIn] |
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Themen: |
Comparative Study |
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Anmerkungen: |
Date Completed 11.04.2008 Date Revised 20.10.2021 published: Print-Electronic Citation Status MEDLINE |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM175541523 |
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100 | 1 | |a Almo, Steven C |e verfasserin |4 aut | |
245 | 1 | 0 | |a Structural genomics of protein phosphatases |
264 | 1 | |c 2007 | |
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500 | |a Date Completed 11.04.2008 | ||
500 | |a Date Revised 20.10.2021 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a The New York SGX Research Center for Structural Genomics (NYSGXRC) of the NIGMS Protein Structure Initiative (PSI) has applied its high-throughput X-ray crystallographic structure determination platform to systematic studies of all human protein phosphatases and protein phosphatases from biomedically-relevant pathogens. To date, the NYSGXRC has determined structures of 21 distinct protein phosphatases: 14 from human, 2 from mouse, 2 from the pathogen Toxoplasma gondii, 1 from Trypanosoma brucei, the parasite responsible for African sleeping sickness, and 2 from the principal mosquito vector of malaria in Africa, Anopheles gambiae. These structures provide insights into both normal and pathophysiologic processes, including transcriptional regulation, regulation of major signaling pathways, neural development, and type 1 diabetes. In conjunction with the contributions of other international structural genomics consortia, these efforts promise to provide an unprecedented database and materials repository for structure-guided experimental and computational discovery of inhibitors for all classes of protein phosphatases | ||
650 | 4 | |a Comparative Study | |
650 | 4 | |a Journal Article | |
650 | 4 | |a Research Support, N.I.H., Extramural | |
650 | 4 | |a Research Support, U.S. Gov't, Non-P.H.S. | |
650 | 4 | |a Review | |
650 | 7 | |a Phosphoprotein Phosphatases |2 NLM | |
650 | 7 | |a EC 3.1.3.16 |2 NLM | |
700 | 1 | |a Bonanno, Jeffrey B |e verfasserin |4 aut | |
700 | 1 | |a Sauder, J Michael |e verfasserin |4 aut | |
700 | 1 | |a Emtage, Spencer |e verfasserin |4 aut | |
700 | 1 | |a Dilorenzo, Teresa P |e verfasserin |4 aut | |
700 | 1 | |a Malashkevich, Vladimir |e verfasserin |4 aut | |
700 | 1 | |a Wasserman, Steven R |e verfasserin |4 aut | |
700 | 1 | |a Swaminathan, S |e verfasserin |4 aut | |
700 | 1 | |a Eswaramoorthy, Subramaniam |e verfasserin |4 aut | |
700 | 1 | |a Agarwal, Rakhi |e verfasserin |4 aut | |
700 | 1 | |a Kumaran, Desigan |e verfasserin |4 aut | |
700 | 1 | |a Madegowda, Mahendra |e verfasserin |4 aut | |
700 | 1 | |a Ragumani, Sugadev |e verfasserin |4 aut | |
700 | 1 | |a Patskovsky, Yury |e verfasserin |4 aut | |
700 | 1 | |a Alvarado, Johnjeff |e verfasserin |4 aut | |
700 | 1 | |a Ramagopal, Udupi A |e verfasserin |4 aut | |
700 | 1 | |a Faber-Barata, Joana |e verfasserin |4 aut | |
700 | 1 | |a Chance, Mark R |e verfasserin |4 aut | |
700 | 1 | |a Sali, Andrej |e verfasserin |4 aut | |
700 | 1 | |a Fiser, Andras |e verfasserin |4 aut | |
700 | 1 | |a Zhang, Zhong-yin |e verfasserin |4 aut | |
700 | 1 | |a Lawrence, David S |e verfasserin |4 aut | |
700 | 1 | |a Burley, Stephen K |e verfasserin |4 aut | |
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